Prospective longitudinal comparative study of health-related quality of life in patients treated with radical prostatectomy or permanent brachytherapy for prostate cancer

Makoto Kobuke, Takashi Saika, Yoshiko Nakanishi, Shin Ebara, Daisuke Manabe, Tatsuya Uesugi, Hiroyuki Nose, Ryoji Arata, Tomoyasu Tsushima, Yasutomo Nasu, Hiromi Kumon

    Research output: Contribution to journalArticlepeer-review

    7 Citations (Scopus)

    Abstract

    To determine health-related quality of life (HRQOL) after radical retropubic prostatectomy (RRP) or permanent prostate brachytherapy (BT), third party-conducted QOL surveys were prospectively compared. Between 2004 and 2005, 37 patients underwent RRP and 36 were treated with BT. A QOL survey consisting of the Medical Outcomes Study 36-Item Short Form (SF-36), the University of California, Los Angeles, Prostate Cancer Index (UCLA-PCI) and the International Prostate Symptoms Score (IPSS) was completed prospectively by a research coordinator at baseline, and at 1, 3, 6 and 12 months after treatment. The RRP patients scored well in general QOL except at 1 month after surgery, with their mental health better than at baseline by 6 months after surgery. Disease-specific QOL in RRP patients received a low score at 1 month for both urinary and sexual function, though urinary function rapidly recovered to baseline levels. BT patient QOL was not affected by the therapy except in the IPSS score. However, general and mental health scores in BT patients were inferior to those in RRP patients. This prospective study revealed differences in QOL after RRP and BT. These results will be helpful in making treatment decisions.

    Original languageEnglish
    Pages (from-to)129-135
    Number of pages7
    JournalActa medica Okayama
    Volume63
    Issue number3
    Publication statusPublished - Jul 2009

    Keywords

    • Brachytherapy
    • Prostate cancer
    • QOL
    • Radical prostatectomy

    ASJC Scopus subject areas

    • Biochemistry, Genetics and Molecular Biology(all)

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