Prospective comparison of various radiological response criteria and pathological response to preoperative chemotherapy and survival in operable high-grade soft tissue sarcomas in the Japan Clinical Oncology Group study JCOG0304

Kazuhiro Tanaka, Gakuto Ogawa, Junki Mizusawa, Norifumi Naka, Akira Kawai, Mitsuru Takahashi, Toru Hiruma, Yoshihiro Matsumoto, Hiroyuki Tsuchiya, Robert Nakayama, Hiroshi Hatano, Makoto Emori, Masami Hosaka, Yukihiro Yoshida, Junya Toguchida, Satoshi Abe, Kunihiro Asanuma, Ryohei Yokoyama, Hiroaki Hiraga, Tsukasa YonemotoTakeshi Morii, Seiichi Matsumoto, Akihito Nagano, Hideki Yoshikawa, Haruhiko Fukuda, Toshihumi Ozaki, Yukihide Iwamoto

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Soft tissue sarcomas (STS) are rare malignant tumors. The efficacy of preoperative chemotherapy for STS is evaluated using various tumor size-based radiological response criteria. However, it is still unclear which set of criteria would show the best association with pathological response and survival of the patients with STS. Methods: We compared radiological responses to preoperative chemotherapy for operable STS by the Response Evaluation Criteria in Solid Tumors (RECIST), modified RECIST, World Health Organization criteria, Japanese Orthopaedic Association criteria, and modified Choi criteria and analyzed the association with pathological response and survival using the data from the Japan Clinical Oncology Group (JCOG) study JCOG0304, a phase II clinical trial evaluating the efficacy of perioperative chemotherapy for STS in the extremities. Results: Seventy eligible patients in JCOG0304 were analyzed. The results demonstrated that none of the size-based radiological response criteria showed significant association with pathological response to preoperative chemotherapy for STS. The difference between overall survival of the patients assessed as partial response and stable disease/progressive disease by RECIST was not significant (hazard ratio 1.37, p = 0.63), and calculated C-index was 0.50. All other response criteria also could not exhibit significant association between radiological responses and survival. Conclusion: In the present study, none of the radiological response criteria analyzed demonstrated association of response to preoperative chemotherapy with pathological response or survival of the patients with operable STS. Further prospective investigation is required to develop criteria to evaluate not only tumor shrinkage but biological effects of preoperative chemotherapy for the patients with localized STS.

Original languageEnglish
Article number162
JournalWorld Journal of Surgical Oncology
Volume16
Issue number1
DOIs
Publication statusPublished - Aug 10 2018

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Medical Oncology
Sarcoma
Japan
Drug Therapy
Survival
Neoplasms
Phase II Clinical Trials
Extremities

Keywords

  • Pathological response
  • Preoperative chemotherapy
  • Radiological response criteria
  • Soft tissue sarcoma
  • Survival

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Prospective comparison of various radiological response criteria and pathological response to preoperative chemotherapy and survival in operable high-grade soft tissue sarcomas in the Japan Clinical Oncology Group study JCOG0304. / Tanaka, Kazuhiro; Ogawa, Gakuto; Mizusawa, Junki; Naka, Norifumi; Kawai, Akira; Takahashi, Mitsuru; Hiruma, Toru; Matsumoto, Yoshihiro; Tsuchiya, Hiroyuki; Nakayama, Robert; Hatano, Hiroshi; Emori, Makoto; Hosaka, Masami; Yoshida, Yukihiro; Toguchida, Junya; Abe, Satoshi; Asanuma, Kunihiro; Yokoyama, Ryohei; Hiraga, Hiroaki; Yonemoto, Tsukasa; Morii, Takeshi; Matsumoto, Seiichi; Nagano, Akihito; Yoshikawa, Hideki; Fukuda, Haruhiko; Ozaki, Toshihumi; Iwamoto, Yukihide.

In: World Journal of Surgical Oncology, Vol. 16, No. 1, 162, 10.08.2018.

Research output: Contribution to journalArticle

Tanaka, K, Ogawa, G, Mizusawa, J, Naka, N, Kawai, A, Takahashi, M, Hiruma, T, Matsumoto, Y, Tsuchiya, H, Nakayama, R, Hatano, H, Emori, M, Hosaka, M, Yoshida, Y, Toguchida, J, Abe, S, Asanuma, K, Yokoyama, R, Hiraga, H, Yonemoto, T, Morii, T, Matsumoto, S, Nagano, A, Yoshikawa, H, Fukuda, H, Ozaki, T & Iwamoto, Y 2018, 'Prospective comparison of various radiological response criteria and pathological response to preoperative chemotherapy and survival in operable high-grade soft tissue sarcomas in the Japan Clinical Oncology Group study JCOG0304', World Journal of Surgical Oncology, vol. 16, no. 1, 162. https://doi.org/10.1186/s12957-018-1462-y
Tanaka, Kazuhiro ; Ogawa, Gakuto ; Mizusawa, Junki ; Naka, Norifumi ; Kawai, Akira ; Takahashi, Mitsuru ; Hiruma, Toru ; Matsumoto, Yoshihiro ; Tsuchiya, Hiroyuki ; Nakayama, Robert ; Hatano, Hiroshi ; Emori, Makoto ; Hosaka, Masami ; Yoshida, Yukihiro ; Toguchida, Junya ; Abe, Satoshi ; Asanuma, Kunihiro ; Yokoyama, Ryohei ; Hiraga, Hiroaki ; Yonemoto, Tsukasa ; Morii, Takeshi ; Matsumoto, Seiichi ; Nagano, Akihito ; Yoshikawa, Hideki ; Fukuda, Haruhiko ; Ozaki, Toshihumi ; Iwamoto, Yukihide. / Prospective comparison of various radiological response criteria and pathological response to preoperative chemotherapy and survival in operable high-grade soft tissue sarcomas in the Japan Clinical Oncology Group study JCOG0304. In: World Journal of Surgical Oncology. 2018 ; Vol. 16, No. 1.
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abstract = "Background: Soft tissue sarcomas (STS) are rare malignant tumors. The efficacy of preoperative chemotherapy for STS is evaluated using various tumor size-based radiological response criteria. However, it is still unclear which set of criteria would show the best association with pathological response and survival of the patients with STS. Methods: We compared radiological responses to preoperative chemotherapy for operable STS by the Response Evaluation Criteria in Solid Tumors (RECIST), modified RECIST, World Health Organization criteria, Japanese Orthopaedic Association criteria, and modified Choi criteria and analyzed the association with pathological response and survival using the data from the Japan Clinical Oncology Group (JCOG) study JCOG0304, a phase II clinical trial evaluating the efficacy of perioperative chemotherapy for STS in the extremities. Results: Seventy eligible patients in JCOG0304 were analyzed. The results demonstrated that none of the size-based radiological response criteria showed significant association with pathological response to preoperative chemotherapy for STS. The difference between overall survival of the patients assessed as partial response and stable disease/progressive disease by RECIST was not significant (hazard ratio 1.37, p = 0.63), and calculated C-index was 0.50. All other response criteria also could not exhibit significant association between radiological responses and survival. Conclusion: In the present study, none of the radiological response criteria analyzed demonstrated association of response to preoperative chemotherapy with pathological response or survival of the patients with operable STS. Further prospective investigation is required to develop criteria to evaluate not only tumor shrinkage but biological effects of preoperative chemotherapy for the patients with localized STS.",
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T1 - Prospective comparison of various radiological response criteria and pathological response to preoperative chemotherapy and survival in operable high-grade soft tissue sarcomas in the Japan Clinical Oncology Group study JCOG0304

AU - Tanaka, Kazuhiro

AU - Ogawa, Gakuto

AU - Mizusawa, Junki

AU - Naka, Norifumi

AU - Kawai, Akira

AU - Takahashi, Mitsuru

AU - Hiruma, Toru

AU - Matsumoto, Yoshihiro

AU - Tsuchiya, Hiroyuki

AU - Nakayama, Robert

AU - Hatano, Hiroshi

AU - Emori, Makoto

AU - Hosaka, Masami

AU - Yoshida, Yukihiro

AU - Toguchida, Junya

AU - Abe, Satoshi

AU - Asanuma, Kunihiro

AU - Yokoyama, Ryohei

AU - Hiraga, Hiroaki

AU - Yonemoto, Tsukasa

AU - Morii, Takeshi

AU - Matsumoto, Seiichi

AU - Nagano, Akihito

AU - Yoshikawa, Hideki

AU - Fukuda, Haruhiko

AU - Ozaki, Toshihumi

AU - Iwamoto, Yukihide

PY - 2018/8/10

Y1 - 2018/8/10

N2 - Background: Soft tissue sarcomas (STS) are rare malignant tumors. The efficacy of preoperative chemotherapy for STS is evaluated using various tumor size-based radiological response criteria. However, it is still unclear which set of criteria would show the best association with pathological response and survival of the patients with STS. Methods: We compared radiological responses to preoperative chemotherapy for operable STS by the Response Evaluation Criteria in Solid Tumors (RECIST), modified RECIST, World Health Organization criteria, Japanese Orthopaedic Association criteria, and modified Choi criteria and analyzed the association with pathological response and survival using the data from the Japan Clinical Oncology Group (JCOG) study JCOG0304, a phase II clinical trial evaluating the efficacy of perioperative chemotherapy for STS in the extremities. Results: Seventy eligible patients in JCOG0304 were analyzed. The results demonstrated that none of the size-based radiological response criteria showed significant association with pathological response to preoperative chemotherapy for STS. The difference between overall survival of the patients assessed as partial response and stable disease/progressive disease by RECIST was not significant (hazard ratio 1.37, p = 0.63), and calculated C-index was 0.50. All other response criteria also could not exhibit significant association between radiological responses and survival. Conclusion: In the present study, none of the radiological response criteria analyzed demonstrated association of response to preoperative chemotherapy with pathological response or survival of the patients with operable STS. Further prospective investigation is required to develop criteria to evaluate not only tumor shrinkage but biological effects of preoperative chemotherapy for the patients with localized STS.

AB - Background: Soft tissue sarcomas (STS) are rare malignant tumors. The efficacy of preoperative chemotherapy for STS is evaluated using various tumor size-based radiological response criteria. However, it is still unclear which set of criteria would show the best association with pathological response and survival of the patients with STS. Methods: We compared radiological responses to preoperative chemotherapy for operable STS by the Response Evaluation Criteria in Solid Tumors (RECIST), modified RECIST, World Health Organization criteria, Japanese Orthopaedic Association criteria, and modified Choi criteria and analyzed the association with pathological response and survival using the data from the Japan Clinical Oncology Group (JCOG) study JCOG0304, a phase II clinical trial evaluating the efficacy of perioperative chemotherapy for STS in the extremities. Results: Seventy eligible patients in JCOG0304 were analyzed. The results demonstrated that none of the size-based radiological response criteria showed significant association with pathological response to preoperative chemotherapy for STS. The difference between overall survival of the patients assessed as partial response and stable disease/progressive disease by RECIST was not significant (hazard ratio 1.37, p = 0.63), and calculated C-index was 0.50. All other response criteria also could not exhibit significant association between radiological responses and survival. Conclusion: In the present study, none of the radiological response criteria analyzed demonstrated association of response to preoperative chemotherapy with pathological response or survival of the patients with operable STS. Further prospective investigation is required to develop criteria to evaluate not only tumor shrinkage but biological effects of preoperative chemotherapy for the patients with localized STS.

KW - Pathological response

KW - Preoperative chemotherapy

KW - Radiological response criteria

KW - Soft tissue sarcoma

KW - Survival

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