Prospective Cohort Study of Congenital Cytomegalovirus Infection during Pregnancy with Fetal Growth Restriction: Serologic Analysis and Placental Pathology

Mitsuru Tsuge, Akira I. Hida, Toshio Minematsu, Naotoshi Honda, Yumi Oshiro, Mikifumi Yokoyama, Yoichi Kondo

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objective: To investigate prospectively the prevalence of congenital cytomegalovirus (CMV) infection and the pathologic features of the placenta in cases of fetal growth restriction (FGR). Study design: Forty-eight pregnant women who were diagnosed with FGR during pregnancy were enrolled for 15 months. Maternal CMV serologic tests, pathologic examinations of the placenta, and newborn urinary CMV-DNA polymerase chain reaction tests were performed in all the cases. The clinical characteristics and laboratory findings of the pregnant women and their newborns were collected. Biomarkers for inflammation, angiogenesis, and placental hormones were measured in the maternal serum at FGR diagnosis or in the neonatal urine at birth. Results: One of the 48 cases with FGR was a congenital CMV infection. CMV antigen was detected in the placenta of 7 cases with FGR. The change rate of the estimated fetal body weight was significantly lower in FGR cases with placental CMV detection. Placental villitis was observed more frequently in FGR cases with placental CMV detection. Human placental lactogen was significantly decreased in FGR cases with placental CMV detection. Increased C-reactive protein and serum amyloid A levels in the maternal serum were observed more frequently in FGR cases with placental CMV detection. Newborn urine β-2 microglobulin levels were significantly higher in FGR cases with placental CMV detection. Conclusions: Serologic tests for maternal CMV, the change rate of the estimated fetal body weight, analysis of several biomarkers, and placental pathologic examinations might be helpful in comprehensively predicting the possibility of congenital CMV infection.

Original languageEnglish
Pages (from-to)42-48.e2
JournalJournal of Pediatrics
Volume206
DOIs
Publication statusPublished - Mar 2019
Externally publishedYes

Keywords

  • chronic villitis
  • estimated fetal body weight
  • human placental lactogen
  • placental dysfunction
  • β-2 microglobulin

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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