Proposal for a unified CCN nomenclature

D. R. Brigstock, R. Goldschmeding, K. I. Katsube, S. C.T. Lam, L. F. Lau, K. Lyons, C. Naus, B. Perbal, B. Riser, M. Takigawa, H. Yeger

Research output: Contribution to journalArticle

193 Citations (Scopus)

Abstract

A proposal is put forth to unify the nomenclature of the CCN family of secreted, cysteine rich regulatory proteins. In the order of their description in the literature, CCN1 (CYR61), CCN2 (CTGF), CCN3 (NOV), CCN4 (WISP-1), CCN5 (WISP-2), and CCN6 (WISP-3) constitute a family of matricellular proteins that regulate cell adhesion, migration, proliferation, survival, and differentiation, at least in part through integrin mediated mechanisms. This proposal is endorsed by the International CCN Society and will serve to eliminate confusion from the multiple names that have been given to these molecules.

Original languageEnglish
Pages (from-to)127-128
Number of pages2
JournalJournal of Clinical Pathology - Molecular Pathology
Volume56
Issue number2
DOIs
Publication statusPublished - Apr 2003

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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    Brigstock, D. R., Goldschmeding, R., Katsube, K. I., Lam, S. C. T., Lau, L. F., Lyons, K., Naus, C., Perbal, B., Riser, B., Takigawa, M., & Yeger, H. (2003). Proposal for a unified CCN nomenclature. Journal of Clinical Pathology - Molecular Pathology, 56(2), 127-128. https://doi.org/10.1136/mp.56.2.127