Propofol suppresses a hyperpolarization-activated inward current in rat hippocampal CA1 neurons

Makoto Funahashi, Hitoshi Higuchi, Takuya Miyawaki, Masahiko Shimada, Ryuji Matsuo

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

We examined the effect of propofol and thiopental, intravenous anesthetics, on the hyperpolarization-activated inward current (IH), whose functional role on the neuronal activity has been evaluated. Whole-cell recordings of IH evoked by hyperpolarizing step pulses were taken from hippocampal CA1 neurons in rat brain slices. Propofol reduced IH current in a dose-dependent manner. However, thiopental had no significant effect on the activation of IH. According to the functional role of IH, the suppression of IH should result in a reduction of neuronal activity. We suggest that the effectiveness of propofol as an anticonvulsant or an antiemetic is associated with the blockade of the IH channel.

Original languageEnglish
Pages (from-to)177-180
Number of pages4
JournalNeuroscience Letters
Volume311
Issue number3
DOIs
Publication statusPublished - Oct 5 2001

Keywords

  • Brain slices
  • CA1
  • Hyperpolarization-activated inward current
  • Propofol
  • Rat
  • Thiopental
  • Whole-cell patch-clamp

ASJC Scopus subject areas

  • Neuroscience(all)

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