Prompt resolution of hypoglycemia by hepatic transarterial embolization for malignant insulinoma with multiple liver metastases

Shinichiro Muro, Junichiro Nasu, Ryo Harada, Minoru Matsubara, Asuka Nakarai, Hiromitsu Kanzaki, Kouichiro Tsutsumi, Hironari Kato, Takehiro Tanaka, Hiroyasu Fujiwara, Masatoshi Uno, Hiroyuki Okada, Kazuhide Yamamoto

Research output: Contribution to journalArticle

3 Citations (Scopus)


A 45-year-old female who presented with loss of consciousness and a cold sweat was found to have a pancreatic tumor and multiple liver metastases. Laboratory studies showed marked hypoglycemia and inappropriately elevated serum insulin, C-peptide, and serum tumor markers. Fine needle aspiration revealed Grade 3 small-cell type primary pancreatic neuroendocrine carcinoma. Consequently, the diagnosis of malignant insulinoma was made. Transarterial embolization (TAE) for hepatic metastases resulted in the reduction of tumor volume and prompt resolution of hypoglycemic attacks, whereas diazoxide and systemic chemotherapy had been ineffective for controlling blood glucose levels, and octreotide was unavailable due to the allergic effect. This case report highlights the potential usefulness of TAE for malignant insulinomas in the management of hypoglycemia.

Original languageEnglish
Pages (from-to)307-311
Number of pages5
JournalActa medica Okayama
Issue number5
Publication statusPublished - Jan 1 2014



  • Hypoglycemia
  • Liver metastases
  • Neuroendocrine tumor
  • Transarterial embolization
  • malignant insulinoma

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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