Promoter analysis of two aromatase genes in the serial-sex changing gobiid fish, Trimma okinawae

Yasuhisa Kobayashi, Tomoki Sunobe, Tohru Kobayashi, Yoshitaka Nagahama, Masaru Nakamura

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


Despite numerous endocrine studies on sex change in teleost, no general mechanism that mediates sex change has emerged. The gobiid fish, Trimma okinawae, can change sex in both directions repeatedly. This phenomenon of sex change in goby assigns it as an excellent animal model to elucidate the understanding mechanisms of sex change. In hermaphrodite fishes, estrogen plays a particularly important role in natural and experimentally induced sex change. To investigate the role of estrogen in the serial-sex changing fish T. okinawae, we cloned and analyzed the 5′-flanking regions of P450arom genes from goby genome DNA. Both regions have consensus sequences of TATA, CRE and ERE. Ad4 binding site was restricted in the region of P450aromA. These findings indicate that different regulators control the expression of the two P450arom genes.

Original languageEnglish
Pages (from-to)123-127
Number of pages5
JournalFish Physiology and Biochemistry
Issue number2-3
Publication statusPublished - Apr 2005


  • Gobiid fish
  • P450 aromatase
  • Promoter
  • Sex change
  • Trimma okinawae

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Aquatic Science


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