Prolonged survival of donor-specific rat intestinal allograft by administration of bone-marrow-derived immature dendritic cells

Dong Sheng Sun, Hiromi Iwagaki, Michitaka Ozaki, Tetsuya Ogino, Satoshi Kusaka, Yoshimi Fujimoto, Hiroshi Murata, Hiroshi Sadamori, Hiroyoshi Matsukawa, Noriaki Tanaka, Takahito Yagi

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10 Citations (Scopus)

Abstract

It has been reported that intraportal administration of donor antigens induced donor-specific hyporesponsiveness. We studied here the effects of transplantation of BM-derived immature dendritic cells (imDCs) and mature DCs (mDCs) via portal vein on rat small intestinal allograft survival. This study comprised four treatment groups: 1) untreated controls; 2) FK506 alone; 3) intraportal donor-specific BM-derived imDCs transplantation+FK506; 4) mDCs/Tx+FK506. Allograft survival was minimal in control group (5.2±0.8 days) and maximal in imDC+FK506 group (28.4±3.0 days). The rats in mDC+FK506 group showed systemic inflammatory reaction due to GVHR, and died within 10 days after transplantation. The in vitro MLR reaction using imDCs was also strongly inhibited both in direct and indirect recognition pathways. The impact of imDCs for the specific induction of transplant tolerance may suggest that immunization with donor-specific imDCs has therapeutic potential in organ transplantation.

Original languageEnglish
Pages (from-to)17-20
Number of pages4
JournalTransplant Immunology
Volume14
Issue number1
DOIs
Publication statusPublished - Mar 2005

Keywords

  • Dendritic cells
  • Small intestinal transplantation
  • Tolerance

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Transplantation

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    Sheng Sun, D., Iwagaki, H., Ozaki, M., Ogino, T., Kusaka, S., Fujimoto, Y., Murata, H., Sadamori, H., Matsukawa, H., Tanaka, N., & Yagi, T. (2005). Prolonged survival of donor-specific rat intestinal allograft by administration of bone-marrow-derived immature dendritic cells. Transplant Immunology, 14(1), 17-20. https://doi.org/10.1016/j.trim.2004.12.002