Proline and glycinebetaine confer cadmium tolerance on tobacco bright yellow-2 cells by increasing scorbate-glutathione cycle enzyme activities

Mohammad Muzahidul Islam, Md Anamul Hoque, Eiji Okuma, Rayhanur Jannat, Mst Nasrin Akhter Banu, Md Sarwar Jahan, Yoshimasa Nakamura, Yoshiyuki Murata

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Cadmium (Cd) stress significantly decreased membrane integrity and impaired the ascorbate (ASC)- glutathione (GSH) cycle in tobacco Bright Yellow-2 cells. Exogenous application of proline and glycinebe- taine (betaine) significantly restored the membrane integrity and increased the activities of ASC-GSH cycle enzymes under Cd stress without maintenance of the rich ASC or GSH pools. Moreover, proline offered more efficient protection against Cd stress than betaine.

Original languageEnglish
Pages (from-to)2320-2323
Number of pages4
JournalBioscience, Biotechnology and Biochemistry
Issue number10
Publication statusPublished - Nov 4 2009



  • Ascorbate-glutathione cycle
  • Cadmium stress
  • Glycinebetaine
  • Proline
  • Reactive oxygen species

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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