Proliferation of Hepatocytes and Attenuation from Carbon Tetrachloride Hepatotoxicity by Gadolinium Chloride in Rats

Hironobu Ishiyama, Makoto Sato, Kuniko Matsumura, Miwa Sento, Keiki Ogino, Tatsuya Hobara

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Abstract: Intravenous injection of gadolinium chloride (GdCl3) at a dose of 10 mg/kg caused an increase in proliferating cell nuclear antigen labeling index and the grade of pyronin positivity (RNA level) in rat liver. In CCl4‐exposed rats, pretreatment with GdCl3 also showed a preventive effect of the liver injury both biochemically and histologically. Moreover, the proliferative action preceded the attenuative effect of the liver injury. Results suggest that GdCl3 induces hepatocyte proliferation, and this action of GdCl3 may modify the development of CCl4‐induced liver injury. 1995 Nordic Pharmacological Society

Original languageEnglish
Pages (from-to)293-298
Number of pages6
JournalPharmacology & Toxicology
Volume77
Issue number4
DOIs
Publication statusPublished - Oct 1995

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology
  • Health, Toxicology and Mutagenesis

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