Proliferation of hepatocytes and attenuation from carbon tetrachloride hepatotoxicity by gadolinium chloride in rats

H. Ishiyama, M. Sato, K. Matsumura, M. Sento, Keiki Ogino, T. Hobara

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Intravenous injection of gadolinium chloride (GdCl3) at a dose of 10 mg/kg caused an increase in proliferating cell nuclear antigen labeling index and the grade of pyronin positivity (RNA level) in rat liver. In CCl4-exposed rats, pretreatment with GdCl3 also showed a preventive effect of the liver injury both biochemically and histologically. Moreover, the proliferative action preceded the attenuative effect of the liver injury. Results suggest that GdCl3 induces hepatocyte proliferation, and this action of GdCl3 may modify the development of CCl4-induced liver injury.

Original languageEnglish
Pages (from-to)293-298
Number of pages6
JournalPharmacology and Toxicology
Volume77
Issue number4
Publication statusPublished - 1995
Externally publishedYes

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Carbon Tetrachloride
Liver
Rats
Hepatocytes
Wounds and Injuries
Proliferating Cell Nuclear Antigen
Intravenous Injections
Labeling
RNA
gadolinium chloride

ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis
  • Pharmacology
  • Toxicology

Cite this

Ishiyama, H., Sato, M., Matsumura, K., Sento, M., Ogino, K., & Hobara, T. (1995). Proliferation of hepatocytes and attenuation from carbon tetrachloride hepatotoxicity by gadolinium chloride in rats. Pharmacology and Toxicology, 77(4), 293-298.

Proliferation of hepatocytes and attenuation from carbon tetrachloride hepatotoxicity by gadolinium chloride in rats. / Ishiyama, H.; Sato, M.; Matsumura, K.; Sento, M.; Ogino, Keiki; Hobara, T.

In: Pharmacology and Toxicology, Vol. 77, No. 4, 1995, p. 293-298.

Research output: Contribution to journalArticle

Ishiyama, H, Sato, M, Matsumura, K, Sento, M, Ogino, K & Hobara, T 1995, 'Proliferation of hepatocytes and attenuation from carbon tetrachloride hepatotoxicity by gadolinium chloride in rats', Pharmacology and Toxicology, vol. 77, no. 4, pp. 293-298.
Ishiyama, H. ; Sato, M. ; Matsumura, K. ; Sento, M. ; Ogino, Keiki ; Hobara, T. / Proliferation of hepatocytes and attenuation from carbon tetrachloride hepatotoxicity by gadolinium chloride in rats. In: Pharmacology and Toxicology. 1995 ; Vol. 77, No. 4. pp. 293-298.
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