Prolactin secretion and ovarian function in cycling and non-cycling African female elephants (Loxodonta africana)

Yuki Yamamoto, Tatsuya Yamamoto, Gen Watanabe, Natsuki Yuto, Megumi Keio, Etsuo Narushima, Masayuki Katayanagi, Risa Nakao, Syu Morikubo, Yuko Sakurai, Mikako Kaneko, Saroch Kaewmanee, Kazuyoshi Taya

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Reproduction of captive elephants in zoos has shown a low fecundity and requires improvement. One of the reasons for low fecundity is ovarian dysfunction in many female elephants. To investigate whether prolactin has a correlation with ovarian function in female elephants, the serum concentrations of prolactin, progesterone and estradiol-17β in four African female elephants (one cycling female and three non-cycling female elephants) were measured. Cyclic patterns of prolactin and estradiol-17β were observed in the cycling female elephant, which tended to be high during the follicular phase and low during the luteal phase. On the other hand, a cyclic pattern of prolactin was not observed in the non-cycling female elephants. One of the three non-cycling females (Mako) had developed breasts and showed significantly higher average levels of prolactin than the other female elephants. These results suggested that high concentrations of circulating estradiol-17β during the follicular phase stimulated prolactin secretion. They also suggested that hyperprolactinemia in Mako was one of the causes of the developed mammary glands and ovarian dysfunction.

Original languageEnglish
Pages (from-to)845-852
Number of pages8
JournalJournal of Veterinary Medical Science
Volume72
Issue number7
DOIs
Publication statusPublished - Jul 2010
Externally publishedYes

Fingerprint

Loxodonta africana
Elephantidae
prolactin
Prolactin
secretion
estradiol
Estradiol
Follicular Phase
Fertility
fecundity
Hyperprolactinemia
Luteal Phase
Human Mammary Glands
zoos
corpus luteum
mammary glands
breasts
Reproduction
Progesterone
progesterone

Keywords

  • African elephant
  • Estrous cycle
  • Hyperprolactinemia
  • Ovarian function
  • Prolactin

ASJC Scopus subject areas

  • veterinary(all)
  • Medicine(all)

Cite this

Prolactin secretion and ovarian function in cycling and non-cycling African female elephants (Loxodonta africana). / Yamamoto, Yuki; Yamamoto, Tatsuya; Watanabe, Gen; Yuto, Natsuki; Keio, Megumi; Narushima, Etsuo; Katayanagi, Masayuki; Nakao, Risa; Morikubo, Syu; Sakurai, Yuko; Kaneko, Mikako; Kaewmanee, Saroch; Taya, Kazuyoshi.

In: Journal of Veterinary Medical Science, Vol. 72, No. 7, 07.2010, p. 845-852.

Research output: Contribution to journalArticle

Yamamoto, Y, Yamamoto, T, Watanabe, G, Yuto, N, Keio, M, Narushima, E, Katayanagi, M, Nakao, R, Morikubo, S, Sakurai, Y, Kaneko, M, Kaewmanee, S & Taya, K 2010, 'Prolactin secretion and ovarian function in cycling and non-cycling African female elephants (Loxodonta africana)', Journal of Veterinary Medical Science, vol. 72, no. 7, pp. 845-852. https://doi.org/10.1292/jvms.09-0480
Yamamoto, Yuki ; Yamamoto, Tatsuya ; Watanabe, Gen ; Yuto, Natsuki ; Keio, Megumi ; Narushima, Etsuo ; Katayanagi, Masayuki ; Nakao, Risa ; Morikubo, Syu ; Sakurai, Yuko ; Kaneko, Mikako ; Kaewmanee, Saroch ; Taya, Kazuyoshi. / Prolactin secretion and ovarian function in cycling and non-cycling African female elephants (Loxodonta africana). In: Journal of Veterinary Medical Science. 2010 ; Vol. 72, No. 7. pp. 845-852.
@article{c89b38b6f72d45a9a7264cd9e5b487d5,
title = "Prolactin secretion and ovarian function in cycling and non-cycling African female elephants (Loxodonta africana)",
abstract = "Reproduction of captive elephants in zoos has shown a low fecundity and requires improvement. One of the reasons for low fecundity is ovarian dysfunction in many female elephants. To investigate whether prolactin has a correlation with ovarian function in female elephants, the serum concentrations of prolactin, progesterone and estradiol-17β in four African female elephants (one cycling female and three non-cycling female elephants) were measured. Cyclic patterns of prolactin and estradiol-17β were observed in the cycling female elephant, which tended to be high during the follicular phase and low during the luteal phase. On the other hand, a cyclic pattern of prolactin was not observed in the non-cycling female elephants. One of the three non-cycling females (Mako) had developed breasts and showed significantly higher average levels of prolactin than the other female elephants. These results suggested that high concentrations of circulating estradiol-17β during the follicular phase stimulated prolactin secretion. They also suggested that hyperprolactinemia in Mako was one of the causes of the developed mammary glands and ovarian dysfunction.",
keywords = "African elephant, Estrous cycle, Hyperprolactinemia, Ovarian function, Prolactin",
author = "Yuki Yamamoto and Tatsuya Yamamoto and Gen Watanabe and Natsuki Yuto and Megumi Keio and Etsuo Narushima and Masayuki Katayanagi and Risa Nakao and Syu Morikubo and Yuko Sakurai and Mikako Kaneko and Saroch Kaewmanee and Kazuyoshi Taya",
year = "2010",
month = "7",
doi = "10.1292/jvms.09-0480",
language = "English",
volume = "72",
pages = "845--852",
journal = "Journal of Veterinary Medical Science",
issn = "0916-7250",
publisher = "Japanese Society of Veterinary Science",
number = "7",

}

TY - JOUR

T1 - Prolactin secretion and ovarian function in cycling and non-cycling African female elephants (Loxodonta africana)

AU - Yamamoto, Yuki

AU - Yamamoto, Tatsuya

AU - Watanabe, Gen

AU - Yuto, Natsuki

AU - Keio, Megumi

AU - Narushima, Etsuo

AU - Katayanagi, Masayuki

AU - Nakao, Risa

AU - Morikubo, Syu

AU - Sakurai, Yuko

AU - Kaneko, Mikako

AU - Kaewmanee, Saroch

AU - Taya, Kazuyoshi

PY - 2010/7

Y1 - 2010/7

N2 - Reproduction of captive elephants in zoos has shown a low fecundity and requires improvement. One of the reasons for low fecundity is ovarian dysfunction in many female elephants. To investigate whether prolactin has a correlation with ovarian function in female elephants, the serum concentrations of prolactin, progesterone and estradiol-17β in four African female elephants (one cycling female and three non-cycling female elephants) were measured. Cyclic patterns of prolactin and estradiol-17β were observed in the cycling female elephant, which tended to be high during the follicular phase and low during the luteal phase. On the other hand, a cyclic pattern of prolactin was not observed in the non-cycling female elephants. One of the three non-cycling females (Mako) had developed breasts and showed significantly higher average levels of prolactin than the other female elephants. These results suggested that high concentrations of circulating estradiol-17β during the follicular phase stimulated prolactin secretion. They also suggested that hyperprolactinemia in Mako was one of the causes of the developed mammary glands and ovarian dysfunction.

AB - Reproduction of captive elephants in zoos has shown a low fecundity and requires improvement. One of the reasons for low fecundity is ovarian dysfunction in many female elephants. To investigate whether prolactin has a correlation with ovarian function in female elephants, the serum concentrations of prolactin, progesterone and estradiol-17β in four African female elephants (one cycling female and three non-cycling female elephants) were measured. Cyclic patterns of prolactin and estradiol-17β were observed in the cycling female elephant, which tended to be high during the follicular phase and low during the luteal phase. On the other hand, a cyclic pattern of prolactin was not observed in the non-cycling female elephants. One of the three non-cycling females (Mako) had developed breasts and showed significantly higher average levels of prolactin than the other female elephants. These results suggested that high concentrations of circulating estradiol-17β during the follicular phase stimulated prolactin secretion. They also suggested that hyperprolactinemia in Mako was one of the causes of the developed mammary glands and ovarian dysfunction.

KW - African elephant

KW - Estrous cycle

KW - Hyperprolactinemia

KW - Ovarian function

KW - Prolactin

UR - http://www.scopus.com/inward/record.url?scp=77955260327&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77955260327&partnerID=8YFLogxK

U2 - 10.1292/jvms.09-0480

DO - 10.1292/jvms.09-0480

M3 - Article

C2 - 20179385

AN - SCOPUS:77955260327

VL - 72

SP - 845

EP - 852

JO - Journal of Veterinary Medical Science

JF - Journal of Veterinary Medical Science

SN - 0916-7250

IS - 7

ER -