Prolactin inhibits osteoclastic activity in the goldfish scale: A novel direct action of prolactin in teleosts

Hideya Takahashi, Nobuo Suzuki, Chiyo Takagi, Mika Ikegame, Toshio Yamamoto, Akiyoshi Takahashi, Shunsuke Moriyama, Atsuhiko Hattori, Tatsuya Sakamoto

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

In teleosts, prolactin is involved in calcium regulation, but its role in scale/bone metabolism Is unclear. Using the in-vitro system with goldfish scales developed recently, we explored the effects of teleost prolactin, growth hormone, and somatolactin on osteoclasts and osteoblasts. Addition of prolactin at concentrations of 0.01-100 ng/ml reduced osteoclastic activity, partly via osteoclast apoptosis, after 6-18 h incubation. Conversely, growth hormone and somatolactin at a concentration of 100 ng/ml increased osteoclastic activity after 18 h incubation, indicating the specificity of the inhibitory effect of prolactin on osteoclastic activity. On the other hand, these three hormones promoted osteoblastic activity at concentrations of 10-100 ng/ml. The results from this study are the first demonstration of direct effects of prolactin on scale/bone metabolism and osteoclastic activity in a teleost.

Original languageEnglish
Pages (from-to)739-745
Number of pages7
JournalZoological Science
Volume25
Issue number7
DOIs
Publication statusPublished - Jul 2008

Fingerprint

goldfish
prolactin
bone metabolism
osteoclasts
somatotropin
osteoblasts
apoptosis
hormones
calcium

Keywords

  • Calcium metabolism
  • Growth hormone
  • Osteoblast
  • Osteoclast
  • Prolactin
  • Scale
  • Somatolactin

ASJC Scopus subject areas

  • Animal Science and Zoology

Cite this

Prolactin inhibits osteoclastic activity in the goldfish scale : A novel direct action of prolactin in teleosts. / Takahashi, Hideya; Suzuki, Nobuo; Takagi, Chiyo; Ikegame, Mika; Yamamoto, Toshio; Takahashi, Akiyoshi; Moriyama, Shunsuke; Hattori, Atsuhiko; Sakamoto, Tatsuya.

In: Zoological Science, Vol. 25, No. 7, 07.2008, p. 739-745.

Research output: Contribution to journalArticle

Takahashi, H, Suzuki, N, Takagi, C, Ikegame, M, Yamamoto, T, Takahashi, A, Moriyama, S, Hattori, A & Sakamoto, T 2008, 'Prolactin inhibits osteoclastic activity in the goldfish scale: A novel direct action of prolactin in teleosts', Zoological Science, vol. 25, no. 7, pp. 739-745. https://doi.org/10.2108/zsj.25.739
Takahashi, Hideya ; Suzuki, Nobuo ; Takagi, Chiyo ; Ikegame, Mika ; Yamamoto, Toshio ; Takahashi, Akiyoshi ; Moriyama, Shunsuke ; Hattori, Atsuhiko ; Sakamoto, Tatsuya. / Prolactin inhibits osteoclastic activity in the goldfish scale : A novel direct action of prolactin in teleosts. In: Zoological Science. 2008 ; Vol. 25, No. 7. pp. 739-745.
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