Prolactin inhibits osteoclastic activity in the goldfish scale: A novel direct action of prolactin in teleosts

Hideya Takahashi, Nobuo Suzuki, Chiyo Takagi, Mika Ikegame, Toshio Yamamoto, Akiyoshi Takahashi, Shunsuke Moriyama, Atsuhiko Hattori, Tatsuya Sakamoto

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

In teleosts, prolactin is involved in calcium regulation, but its role in scale/bone metabolism Is unclear. Using the in-vitro system with goldfish scales developed recently, we explored the effects of teleost prolactin, growth hormone, and somatolactin on osteoclasts and osteoblasts. Addition of prolactin at concentrations of 0.01-100 ng/ml reduced osteoclastic activity, partly via osteoclast apoptosis, after 6-18 h incubation. Conversely, growth hormone and somatolactin at a concentration of 100 ng/ml increased osteoclastic activity after 18 h incubation, indicating the specificity of the inhibitory effect of prolactin on osteoclastic activity. On the other hand, these three hormones promoted osteoblastic activity at concentrations of 10-100 ng/ml. The results from this study are the first demonstration of direct effects of prolactin on scale/bone metabolism and osteoclastic activity in a teleost.

Original languageEnglish
Pages (from-to)739-745
Number of pages7
JournalZoological science
Volume25
Issue number7
DOIs
Publication statusPublished - Jul 2008

Keywords

  • Calcium metabolism
  • Growth hormone
  • Osteoblast
  • Osteoclast
  • Prolactin
  • Scale
  • Somatolactin

ASJC Scopus subject areas

  • Animal Science and Zoology

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