Progressive multifocal leukoencephalopathy after T-cell replete HLA-haploidentical transplantation with post-transplantation cyclophosphamide graft-versus-host disease prophylaxis

Shuntaro Ikegawa, Nobuharu Fujii, Koh Tadokoro, Kota Sato, Miki Iwamoto, Masayuki Matsuda, Tomoko Inomata, Hiroyuki Sugiura, Takeru Asano, Shohei Yoshida, Hisakazu Nishimori, Ken-ichi Matsuoka, Yoshinobu Maeda

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

A 52-year-old man suffered from progressive multifocal leukoencephalopathy (PML) after human leukocyte antigen (HLA)-haploidentical transplantation with post-transplantation cyclophosphamide (PTCY). Mirtazapine, mefloquine, and cytarabine failed to improve his symptoms, and he finally died 4.5 months after PML onset. This is the first case report of a patient with PML after HLA-haploidentical transplantation with PTCY. Although T-cell replete HLA-haploidentical transplantation with PTCY has enabled early immune reconstitution, PML should be considered if a patient's mental condition deteriorates.

Original languageEnglish
Article numbere12850
JournalTransplant Infectious Disease
Volume20
Issue number2
DOIs
Publication statusPublished - Apr 1 2018

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Progressive Multifocal Leukoencephalopathy
Graft vs Host Disease
HLA Antigens
Cyclophosphamide
Transplantation
T-Lymphocytes
Mefloquine
Cytarabine
Mentally Ill Persons

Keywords

  • haploidentical transplantation
  • post-transplantation cyclophosphamide
  • progressive multifocal leukoencephalopathy

ASJC Scopus subject areas

  • Transplantation
  • Infectious Diseases

Cite this

Progressive multifocal leukoencephalopathy after T-cell replete HLA-haploidentical transplantation with post-transplantation cyclophosphamide graft-versus-host disease prophylaxis. / Ikegawa, Shuntaro; Fujii, Nobuharu; Tadokoro, Koh; Sato, Kota; Iwamoto, Miki; Matsuda, Masayuki; Inomata, Tomoko; Sugiura, Hiroyuki; Asano, Takeru; Yoshida, Shohei; Nishimori, Hisakazu; Matsuoka, Ken-ichi; Maeda, Yoshinobu.

In: Transplant Infectious Disease, Vol. 20, No. 2, e12850, 01.04.2018.

Research output: Contribution to journalArticle

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AU - Ikegawa, Shuntaro

AU - Fujii, Nobuharu

AU - Tadokoro, Koh

AU - Sato, Kota

AU - Iwamoto, Miki

AU - Matsuda, Masayuki

AU - Inomata, Tomoko

AU - Sugiura, Hiroyuki

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AU - Yoshida, Shohei

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AU - Matsuoka, Ken-ichi

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