Abstract
A 52-year-old man suffered from progressive multifocal leukoencephalopathy (PML) after human leukocyte antigen (HLA)-haploidentical transplantation with post-transplantation cyclophosphamide (PTCY). Mirtazapine, mefloquine, and cytarabine failed to improve his symptoms, and he finally died 4.5 months after PML onset. This is the first case report of a patient with PML after HLA-haploidentical transplantation with PTCY. Although T-cell replete HLA-haploidentical transplantation with PTCY has enabled early immune reconstitution, PML should be considered if a patient's mental condition deteriorates.
| Original language | English |
|---|---|
| Article number | e12850 |
| Journal | Transplant Infectious Disease |
| Volume | 20 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Apr 1 2018 |
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Keywords
- haploidentical transplantation
- post-transplantation cyclophosphamide
- progressive multifocal leukoencephalopathy
ASJC Scopus subject areas
- Transplantation
- Infectious Diseases
Cite this
Progressive multifocal leukoencephalopathy after T-cell replete HLA-haploidentical transplantation with post-transplantation cyclophosphamide graft-versus-host disease prophylaxis. / Ikegawa, Shuntaro; Fujii, Nobuharu; Tadokoro, Koh; Sato, Kota; Iwamoto, Miki; Matsuda, Masayuki; Inomata, Tomoko; Sugiura, Hiroyuki; Asano, Takeru; Yoshida, Shohei; Nishimori, Hisakazu; Matsuoka, Ken-ichi; Maeda, Yoshinobu.
In: Transplant Infectious Disease, Vol. 20, No. 2, e12850, 01.04.2018.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Progressive multifocal leukoencephalopathy after T-cell replete HLA-haploidentical transplantation with post-transplantation cyclophosphamide graft-versus-host disease prophylaxis
AU - Ikegawa, Shuntaro
AU - Fujii, Nobuharu
AU - Tadokoro, Koh
AU - Sato, Kota
AU - Iwamoto, Miki
AU - Matsuda, Masayuki
AU - Inomata, Tomoko
AU - Sugiura, Hiroyuki
AU - Asano, Takeru
AU - Yoshida, Shohei
AU - Nishimori, Hisakazu
AU - Matsuoka, Ken-ichi
AU - Maeda, Yoshinobu
PY - 2018/4/1
Y1 - 2018/4/1
N2 - A 52-year-old man suffered from progressive multifocal leukoencephalopathy (PML) after human leukocyte antigen (HLA)-haploidentical transplantation with post-transplantation cyclophosphamide (PTCY). Mirtazapine, mefloquine, and cytarabine failed to improve his symptoms, and he finally died 4.5 months after PML onset. This is the first case report of a patient with PML after HLA-haploidentical transplantation with PTCY. Although T-cell replete HLA-haploidentical transplantation with PTCY has enabled early immune reconstitution, PML should be considered if a patient's mental condition deteriorates.
AB - A 52-year-old man suffered from progressive multifocal leukoencephalopathy (PML) after human leukocyte antigen (HLA)-haploidentical transplantation with post-transplantation cyclophosphamide (PTCY). Mirtazapine, mefloquine, and cytarabine failed to improve his symptoms, and he finally died 4.5 months after PML onset. This is the first case report of a patient with PML after HLA-haploidentical transplantation with PTCY. Although T-cell replete HLA-haploidentical transplantation with PTCY has enabled early immune reconstitution, PML should be considered if a patient's mental condition deteriorates.
KW - haploidentical transplantation
KW - post-transplantation cyclophosphamide
KW - progressive multifocal leukoencephalopathy
UR - http://www.scopus.com/inward/record.url?scp=85042588813&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85042588813&partnerID=8YFLogxK
U2 - 10.1111/tid.12850
DO - 10.1111/tid.12850
M3 - Article
C2 - 29359846
AN - SCOPUS:85042593243
VL - 20
JO - Transplant Infectious Disease
JF - Transplant Infectious Disease
SN - 1398-2273
IS - 2
M1 - e12850
ER -