Progressive multifocal leukoencephalopathy after T-cell replete HLA-haploidentical transplantation with post-transplantation cyclophosphamide graft-versus-host disease prophylaxis

Shuntaro Ikegawa; Nobuharu Fujii; Koh Tadokoro; Kota Sato; Miki Iwamoto; Masayuki Matsuda; Tomoko Inomata; Hiroyuki Sugiura; Takeru Asano; Shohei Yoshida; Hisakazu Nishimori; Ken Ichi Matsuoka; Yoshinobu Maeda

doi:10.1111/tid.12850

Progressive multifocal leukoencephalopathy after T-cell replete HLA-haploidentical transplantation with post-transplantation cyclophosphamide graft-versus-host disease prophylaxis

Shuntaro Ikegawa, Nobuharu Fujii, Koh Tadokoro, Kota Sato, Miki Iwamoto, Masayuki Matsuda, Tomoko Inomata, Hiroyuki Sugiura, Takeru Asano, Shohei Yoshida, Hisakazu Nishimori, Ken Ichi Matsuoka, Yoshinobu Maeda

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

A 52-year-old man suffered from progressive multifocal leukoencephalopathy (PML) after human leukocyte antigen (HLA)-haploidentical transplantation with post-transplantation cyclophosphamide (PTCY). Mirtazapine, mefloquine, and cytarabine failed to improve his symptoms, and he finally died 4.5 months after PML onset. This is the first case report of a patient with PML after HLA-haploidentical transplantation with PTCY. Although T-cell replete HLA-haploidentical transplantation with PTCY has enabled early immune reconstitution, PML should be considered if a patient's mental condition deteriorates.

Original language	English
Article number	e12850
Journal	Transplant Infectious Disease
Volume	20
Issue number	2
DOIs	https://doi.org/10.1111/tid.12850
Publication status	Published - Apr 2018

Keywords

haploidentical transplantation
post-transplantation cyclophosphamide
progressive multifocal leukoencephalopathy

ASJC Scopus subject areas

Infectious Diseases
Transplantation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/tid.12850

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Ikegawa, S., Fujii, N., Tadokoro, K., Sato, K., Iwamoto, M., Matsuda, M., Inomata, T., Sugiura, H., Asano, T., Yoshida, S., Nishimori, H., Matsuoka, K. I., & Maeda, Y. (2018). Progressive multifocal leukoencephalopathy after T-cell replete HLA-haploidentical transplantation with post-transplantation cyclophosphamide graft-versus-host disease prophylaxis. Transplant Infectious Disease, 20(2), [e12850]. https://doi.org/10.1111/tid.12850

Progressive multifocal leukoencephalopathy after T-cell replete HLA-haploidentical transplantation with post-transplantation cyclophosphamide graft-versus-host disease prophylaxis. / Ikegawa, Shuntaro; Fujii, Nobuharu; Tadokoro, Koh et al.

In: Transplant Infectious Disease, Vol. 20, No. 2, e12850, 04.2018.

Research output: Contribution to journal › Article › peer-review

Ikegawa, S, Fujii, N, Tadokoro, K, Sato, K, Iwamoto, M, Matsuda, M, Inomata, T, Sugiura, H, Asano, T, Yoshida, S, Nishimori, H , Matsuoka, KI & Maeda, Y 2018, 'Progressive multifocal leukoencephalopathy after T-cell replete HLA-haploidentical transplantation with post-transplantation cyclophosphamide graft-versus-host disease prophylaxis', Transplant Infectious Disease, vol. 20, no. 2, e12850. https://doi.org/10.1111/tid.12850

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title = "Progressive multifocal leukoencephalopathy after T-cell replete HLA-haploidentical transplantation with post-transplantation cyclophosphamide graft-versus-host disease prophylaxis",

abstract = "A 52-year-old man suffered from progressive multifocal leukoencephalopathy (PML) after human leukocyte antigen (HLA)-haploidentical transplantation with post-transplantation cyclophosphamide (PTCY). Mirtazapine, mefloquine, and cytarabine failed to improve his symptoms, and he finally died 4.5 months after PML onset. This is the first case report of a patient with PML after HLA-haploidentical transplantation with PTCY. Although T-cell replete HLA-haploidentical transplantation with PTCY has enabled early immune reconstitution, PML should be considered if a patient's mental condition deteriorates.",

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author = "Shuntaro Ikegawa and Nobuharu Fujii and Koh Tadokoro and Kota Sato and Miki Iwamoto and Masayuki Matsuda and Tomoko Inomata and Hiroyuki Sugiura and Takeru Asano and Shohei Yoshida and Hisakazu Nishimori and Matsuoka, {Ken Ichi} and Yoshinobu Maeda",

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AU - Ikegawa, Shuntaro

AU - Fujii, Nobuharu

AU - Tadokoro, Koh

AU - Sato, Kota

AU - Iwamoto, Miki

AU - Matsuda, Masayuki

AU - Inomata, Tomoko

AU - Sugiura, Hiroyuki

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AU - Nishimori, Hisakazu

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AB - A 52-year-old man suffered from progressive multifocal leukoencephalopathy (PML) after human leukocyte antigen (HLA)-haploidentical transplantation with post-transplantation cyclophosphamide (PTCY). Mirtazapine, mefloquine, and cytarabine failed to improve his symptoms, and he finally died 4.5 months after PML onset. This is the first case report of a patient with PML after HLA-haploidentical transplantation with PTCY. Although T-cell replete HLA-haploidentical transplantation with PTCY has enabled early immune reconstitution, PML should be considered if a patient's mental condition deteriorates.

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KW - post-transplantation cyclophosphamide

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Progressive multifocal leukoencephalopathy after T-cell replete HLA-haploidentical transplantation with post-transplantation cyclophosphamide graft-versus-host disease prophylaxis

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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