Progressive multifocal leukoencephalopathy after T-cell replete HLA-haploidentical transplantation with post-transplantation cyclophosphamide graft-versus-host disease prophylaxis

Shuntaro Ikegawa, Nobuharu Fujii, Koh Tadokoro, Kota Sato, Miki Iwamoto, Masayuki Matsuda, Tomoko Inomata, Hiroyuki Sugiura, Takeru Asano, Shohei Yoshida, Hisakazu Nishimori, Ken Ichi Matsuoka, Yoshinobu Maeda

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1 Citation (Scopus)

Abstract

A 52-year-old man suffered from progressive multifocal leukoencephalopathy (PML) after human leukocyte antigen (HLA)-haploidentical transplantation with post-transplantation cyclophosphamide (PTCY). Mirtazapine, mefloquine, and cytarabine failed to improve his symptoms, and he finally died 4.5 months after PML onset. This is the first case report of a patient with PML after HLA-haploidentical transplantation with PTCY. Although T-cell replete HLA-haploidentical transplantation with PTCY has enabled early immune reconstitution, PML should be considered if a patient's mental condition deteriorates.

Original languageEnglish
Article numbere12850
JournalTransplant Infectious Disease
Volume20
Issue number2
DOIs
Publication statusPublished - Apr 2018

Keywords

  • haploidentical transplantation
  • post-transplantation cyclophosphamide
  • progressive multifocal leukoencephalopathy

ASJC Scopus subject areas

  • Infectious Diseases
  • Transplantation

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