Progressive multifocal leukoencephalopathy after T-cell replete HLA-haploidentical transplantation with post-transplantation cyclophosphamide graft-versus-host disease prophylaxis

Shuntaro Ikegawa; Nobuharu Fujii; Koh Tadokoro; Kota Sato; Miki Iwamoto; Masayuki Matsuda; Tomoko Inomata; Hiroyuki Sugiura; Takeru Asano; Shohei Yoshida; Hisakazu Nishimori; Ken-ichi Matsuoka; Yoshinobu Maeda

doi:10.1111/tid.12850

Progressive multifocal leukoencephalopathy after T-cell replete HLA-haploidentical transplantation with post-transplantation cyclophosphamide graft-versus-host disease prophylaxis

Shuntaro Ikegawa, Nobuharu Fujii, Koh Tadokoro, Kota Sato, Miki Iwamoto, Masayuki Matsuda, Tomoko Inomata, Hiroyuki Sugiura, Takeru Asano, Shohei Yoshida, Hisakazu Nishimori, Ken-ichi Matsuoka, Yoshinobu Maeda

Research output: Contribution to journal › Article

1 Citation (Scopus)

Abstract

A 52-year-old man suffered from progressive multifocal leukoencephalopathy (PML) after human leukocyte antigen (HLA)-haploidentical transplantation with post-transplantation cyclophosphamide (PTCY). Mirtazapine, mefloquine, and cytarabine failed to improve his symptoms, and he finally died 4.5 months after PML onset. This is the first case report of a patient with PML after HLA-haploidentical transplantation with PTCY. Although T-cell replete HLA-haploidentical transplantation with PTCY has enabled early immune reconstitution, PML should be considered if a patient's mental condition deteriorates.

Original language	English
Article number	e12850
Journal	Transplant Infectious Disease
Volume	20
Issue number	2
DOIs	https://doi.org/10.1111/tid.12850
Publication status	Published - Apr 1 2018

Keywords

haploidentical transplantation
post-transplantation cyclophosphamide
progressive multifocal leukoencephalopathy

ASJC Scopus subject areas

Transplantation
Infectious Diseases

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Ikegawa, S., Fujii, N., Tadokoro, K., Sato, K., Iwamoto, M., Matsuda, M., Inomata, T., Sugiura, H., Asano, T., Yoshida, S., Nishimori, H., Matsuoka, K., & Maeda, Y. (2018). Progressive multifocal leukoencephalopathy after T-cell replete HLA-haploidentical transplantation with post-transplantation cyclophosphamide graft-versus-host disease prophylaxis. Transplant Infectious Disease, 20(2), [e12850]. https://doi.org/10.1111/tid.12850

Progressive multifocal leukoencephalopathy after T-cell replete HLA-haploidentical transplantation with post-transplantation cyclophosphamide graft-versus-host disease prophylaxis. / Ikegawa, Shuntaro; Fujii, Nobuharu; Tadokoro, Koh; Sato, Kota; Iwamoto, Miki; Matsuda, Masayuki; Inomata, Tomoko; Sugiura, Hiroyuki; Asano, Takeru; Yoshida, Shohei; Nishimori, Hisakazu ; Matsuoka, Ken-ichi ; Maeda, Yoshinobu.

In: Transplant Infectious Disease, Vol. 20, No. 2, e12850, 01.04.2018.

Research output: Contribution to journal › Article

Ikegawa, S, Fujii, N, Tadokoro, K, Sato, K, Iwamoto, M, Matsuda, M, Inomata, T, Sugiura, H, Asano, T, Yoshida, S, Nishimori, H , Matsuoka, K & Maeda, Y 2018, 'Progressive multifocal leukoencephalopathy after T-cell replete HLA-haploidentical transplantation with post-transplantation cyclophosphamide graft-versus-host disease prophylaxis', Transplant Infectious Disease, vol. 20, no. 2, e12850. https://doi.org/10.1111/tid.12850

Ikegawa, Shuntaro ; Fujii, Nobuharu ; Tadokoro, Koh ; Sato, Kota ; Iwamoto, Miki ; Matsuda, Masayuki ; Inomata, Tomoko ; Sugiura, Hiroyuki ; Asano, Takeru ; Yoshida, Shohei ; Nishimori, Hisakazu ; Matsuoka, Ken-ichi ; Maeda, Yoshinobu. / Progressive multifocal leukoencephalopathy after T-cell replete HLA-haploidentical transplantation with post-transplantation cyclophosphamide graft-versus-host disease prophylaxis. In: Transplant Infectious Disease. 2018 ; Vol. 20, No. 2.

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