Progression of pulmonary artery dilatation in patients with pulmonary hypertension coexisting with a pulmonary artery aneurysm

Satoshi Akagi, Kazufumi Nakamura, Toshihiro Sarashina, Kentaro Ejiri, Shingo Kasahara, Hiroshi Itoh

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Pulmonary artery (PA) dilatation is usually observed in patients with pulmonary hypertension (PH), but a PA aneurysm (PA diameter > 40. mm) is rare. The difference between characteristics of patients with and those without progression of PA diameter remains poorly understood. We assessed the changes in PA diameter in patients with PH coexisting with and without a PA aneurysm. Methods: We investigated the changes in PA diameter by multi-detector computed tomography performed twice with an interval of more than one year in 44 patients with PH. Seventeen patients had a PA aneurysm and 27 patients did not have a PA aneurysm at baseline. Results: The median follow-up period was 3.6 years. All patients received medical or invasive treatment for PH. At baseline, main PA diameters were 52. ±. 15. mm in patients with a PA aneurysm and 33. ±. 3. mm in patients without a PA aneurysm. Mean PA pressure was higher in patients with a PA aneurysm than in those without a PA aneurysm (61. ±. 15. mmHg vs. 51. ±. 16. mmHg, p = 0.04). At follow-up, mean PA pressure significantly decreased in both patients with a PA aneurysm (44. ±. 11. mmHg) and patients without a PA aneurysm (41. ±. 18. mmHg). Main PA diameter significantly increased in patients with a PA aneurysm (65. ±. 28. mm, change ratio: 23.3%), while it did not increase in patients without a PA aneurysm (32. ±. 3. mm, change ratio: -3.1%). Conclusions: PA dilatation progressed in patients with a PA aneurysm despite treatment of PH. The progression of PA dilatation is independent of reduction of PA pressure by PH treatment.

Original languageEnglish
JournalJournal of Cardiology
DOIs
Publication statusAccepted/In press - Jan 1 2017

Fingerprint

Pulmonary Hypertension
Pulmonary Artery
Aneurysm
Dilatation
Pressure

Keywords

  • Pulmonary artery aneurysm
  • Pulmonary hypertension
  • Treatment

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

@article{2dc33e6270a54dd4887f9a03c6a1f077,
title = "Progression of pulmonary artery dilatation in patients with pulmonary hypertension coexisting with a pulmonary artery aneurysm",
abstract = "Background: Pulmonary artery (PA) dilatation is usually observed in patients with pulmonary hypertension (PH), but a PA aneurysm (PA diameter > 40. mm) is rare. The difference between characteristics of patients with and those without progression of PA diameter remains poorly understood. We assessed the changes in PA diameter in patients with PH coexisting with and without a PA aneurysm. Methods: We investigated the changes in PA diameter by multi-detector computed tomography performed twice with an interval of more than one year in 44 patients with PH. Seventeen patients had a PA aneurysm and 27 patients did not have a PA aneurysm at baseline. Results: The median follow-up period was 3.6 years. All patients received medical or invasive treatment for PH. At baseline, main PA diameters were 52. ±. 15. mm in patients with a PA aneurysm and 33. ±. 3. mm in patients without a PA aneurysm. Mean PA pressure was higher in patients with a PA aneurysm than in those without a PA aneurysm (61. ±. 15. mmHg vs. 51. ±. 16. mmHg, p = 0.04). At follow-up, mean PA pressure significantly decreased in both patients with a PA aneurysm (44. ±. 11. mmHg) and patients without a PA aneurysm (41. ±. 18. mmHg). Main PA diameter significantly increased in patients with a PA aneurysm (65. ±. 28. mm, change ratio: 23.3{\%}), while it did not increase in patients without a PA aneurysm (32. ±. 3. mm, change ratio: -3.1{\%}). Conclusions: PA dilatation progressed in patients with a PA aneurysm despite treatment of PH. The progression of PA dilatation is independent of reduction of PA pressure by PH treatment.",
keywords = "Pulmonary artery aneurysm, Pulmonary hypertension, Treatment",
author = "Satoshi Akagi and Kazufumi Nakamura and Toshihiro Sarashina and Kentaro Ejiri and Shingo Kasahara and Hiroshi Itoh",
year = "2017",
month = "1",
day = "1",
doi = "10.1016/j.jjcc.2017.11.005",
language = "English",
journal = "Journal of cardiography. Supplement",
issn = "0914-5087",
publisher = "Japanese College of Cardiology (Nippon-Sinzobyo-Gakkai)",

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TY - JOUR

T1 - Progression of pulmonary artery dilatation in patients with pulmonary hypertension coexisting with a pulmonary artery aneurysm

AU - Akagi, Satoshi

AU - Nakamura, Kazufumi

AU - Sarashina, Toshihiro

AU - Ejiri, Kentaro

AU - Kasahara, Shingo

AU - Itoh, Hiroshi

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Background: Pulmonary artery (PA) dilatation is usually observed in patients with pulmonary hypertension (PH), but a PA aneurysm (PA diameter > 40. mm) is rare. The difference between characteristics of patients with and those without progression of PA diameter remains poorly understood. We assessed the changes in PA diameter in patients with PH coexisting with and without a PA aneurysm. Methods: We investigated the changes in PA diameter by multi-detector computed tomography performed twice with an interval of more than one year in 44 patients with PH. Seventeen patients had a PA aneurysm and 27 patients did not have a PA aneurysm at baseline. Results: The median follow-up period was 3.6 years. All patients received medical or invasive treatment for PH. At baseline, main PA diameters were 52. ±. 15. mm in patients with a PA aneurysm and 33. ±. 3. mm in patients without a PA aneurysm. Mean PA pressure was higher in patients with a PA aneurysm than in those without a PA aneurysm (61. ±. 15. mmHg vs. 51. ±. 16. mmHg, p = 0.04). At follow-up, mean PA pressure significantly decreased in both patients with a PA aneurysm (44. ±. 11. mmHg) and patients without a PA aneurysm (41. ±. 18. mmHg). Main PA diameter significantly increased in patients with a PA aneurysm (65. ±. 28. mm, change ratio: 23.3%), while it did not increase in patients without a PA aneurysm (32. ±. 3. mm, change ratio: -3.1%). Conclusions: PA dilatation progressed in patients with a PA aneurysm despite treatment of PH. The progression of PA dilatation is independent of reduction of PA pressure by PH treatment.

AB - Background: Pulmonary artery (PA) dilatation is usually observed in patients with pulmonary hypertension (PH), but a PA aneurysm (PA diameter > 40. mm) is rare. The difference between characteristics of patients with and those without progression of PA diameter remains poorly understood. We assessed the changes in PA diameter in patients with PH coexisting with and without a PA aneurysm. Methods: We investigated the changes in PA diameter by multi-detector computed tomography performed twice with an interval of more than one year in 44 patients with PH. Seventeen patients had a PA aneurysm and 27 patients did not have a PA aneurysm at baseline. Results: The median follow-up period was 3.6 years. All patients received medical or invasive treatment for PH. At baseline, main PA diameters were 52. ±. 15. mm in patients with a PA aneurysm and 33. ±. 3. mm in patients without a PA aneurysm. Mean PA pressure was higher in patients with a PA aneurysm than in those without a PA aneurysm (61. ±. 15. mmHg vs. 51. ±. 16. mmHg, p = 0.04). At follow-up, mean PA pressure significantly decreased in both patients with a PA aneurysm (44. ±. 11. mmHg) and patients without a PA aneurysm (41. ±. 18. mmHg). Main PA diameter significantly increased in patients with a PA aneurysm (65. ±. 28. mm, change ratio: 23.3%), while it did not increase in patients without a PA aneurysm (32. ±. 3. mm, change ratio: -3.1%). Conclusions: PA dilatation progressed in patients with a PA aneurysm despite treatment of PH. The progression of PA dilatation is independent of reduction of PA pressure by PH treatment.

KW - Pulmonary artery aneurysm

KW - Pulmonary hypertension

KW - Treatment

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U2 - 10.1016/j.jjcc.2017.11.005

DO - 10.1016/j.jjcc.2017.11.005

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JO - Journal of cardiography. Supplement

JF - Journal of cardiography. Supplement

SN - 0914-5087

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