Progress in researches about focal adhesion kinase in gastrointestinal tract

Hui Fang Hao, Yoshio Naomoto, Xiao Hong Bao, Nobuyuki Watanabe, Kazufumi Sakurama, Kazuhiro Noma, Yasuko Tomono, Takuya Fukazawa, Yasuhiro Shirakawa, Tomoki Yamatsuji, Junji Matsuoka, Munenori Takaoka

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Focal adhesion kinase (FAK) is a 125-kDa non-receptor protein tyrosine. Growth factors or the clustering of integrins facilitate the rapid phosphorylation of FAK at Tyr-397 and this in turn recruits Src-family protein tyrosine kinases, resulting in the phosphorylation of Tyr-576 and Tyr-577 in the FAK activation loop and full catalytic FAK activation. FAK plays a critical role in the biological processes of normal and cancer cells including the gastrointestinal tract. FAK also plays an important role in the restitution, cell survival and apoptosis and carcinogenesis of the gastrointestinal tract. FAK is over-expressed in cancer cells and its over-expression and elevated activities are associated with motility and invasion of cancer cells. FAK has been proposed as a potential target in cancer therapy. Small molecule inhibitors effectively inhibit the kinase activity of FAK and show a potent inhibitory effect for the proliferation and migration of tumor cells, indicating a high potential for application in cancer therapy.

Original languageEnglish
Pages (from-to)5916-5923
Number of pages8
JournalWorld Journal of Gastroenterology
Volume15
Issue number47
DOIs
Publication statusPublished - Dec 21 2009

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Keywords

  • Cancer
  • Focal adhesion kinase
  • Inhibitor
  • Restitution
  • Survival and apoptosis

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Hao, H. F., Naomoto, Y., Bao, X. H., Watanabe, N., Sakurama, K., Noma, K., Tomono, Y., Fukazawa, T., Shirakawa, Y., Yamatsuji, T., Matsuoka, J., & Takaoka, M. (2009). Progress in researches about focal adhesion kinase in gastrointestinal tract. World Journal of Gastroenterology, 15(47), 5916-5923. https://doi.org/10.3748/wjg.15.5916