Progress and prognosis in 9 patients after CP therapy (combination of cisplatin and peplomycin)

Junichi Asaumi, Shigeki Koyama, Keishi Tsuruta, Nobuyuki Ikegami, Katsumi Nishijima

Research output: Contribution to journalArticle

Abstract

The effects and complications associated with cisplatin and peplomycin combination chemotherapy (CP therapy) are reported. Nine patients with head and neck cancer were treated as follows: cisplatin (75 mg/body) was administered by intravenous infusion continuously for 24 h, followed by continuous peplomycin (5 mg/body) intravenous infusion for 5 h per day for 2 or 6 days. A complete response (CR) was attained in 2 patients and a partial response (PR) in 5. Complications observed were: leukocytopenia (7), anemia (6), nausea or vomiting (4), renal disorder (4), fever (2), increased serum transaminase levels (6) and hair loss (3). It is concluded that CP therapy was effective and safe as neo-adjuvant treatment for patients with head and neck cancer.

Original languageEnglish
Pages (from-to)166-173
Number of pages8
JournalORAL THERAPEUTICS AND PHARMACOLOGY
Volume6
Issue number3
DOIs
Publication statusPublished - 1987

Keywords

  • CP
  • CP therapy
  • Neo-adjuvant chemotherapy
  • complications

ASJC Scopus subject areas

  • Dentistry(all)
  • Pharmacology
  • Pharmacology (medical)

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