TY - JOUR
T1 - Prognostic significance of the thymidine phosphorylase/dihydropyrimidine dehydrogenase ratio in invasive cervical cancer
AU - Kodama, Junichi
AU - Hasengaowa,
AU - Shinyo, Yasuhiro
AU - Kusumoto, Tomoyuki
AU - Seki, Noriko
AU - Nakamura, Yojiro
AU - Nakamura, Keiichiro
AU - Hongo, Atsushi
AU - Hiramatsu, Yuji
N1 - Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.
PY - 2005/7/1
Y1 - 2005/7/1
N2 - Objective: In this study, we measured both thymidine phosphorylase (TP) and dihydropyrimidine dehydrogenase (DPD) levels, and then determined the TP/DPD ratios, in a number of invasive cervical cancers. Our aim was to investigate the association between these values and the clinicopathological features of invasive cervical cancer, including patient prognosis. Study design: Using enzyme-linked immunosorbent assays, the TP and DPD activities were quantitatively measured in 51 patients with cervical cancer who had also undergone a radical hysterectomy. Results: The TP, DPD and TP/DPD values in squamous cell carcinoma (SCC) were found to be significantly higher than the levels in non-SCC. Furthermore, in a SCC subgroup, the TP/DPD levels were significantly higher in cases where parametrial invasion was evident, and in a non-SCC subgroup, these levels were also significantly higher in cases with deep stromal invasion, lymph-vascular space invasion, large tumor size and parametrial invasion. The disease-free survival rate is shown to be significantly higher in patients with low TP/DPD levels indicating that this ratio may be associated with both the progression and recurrence of invasive cervical cancer. Conclusion: TP/DPD ratios may be associated with both the progression and recurrence of invasive cervical cancer.
AB - Objective: In this study, we measured both thymidine phosphorylase (TP) and dihydropyrimidine dehydrogenase (DPD) levels, and then determined the TP/DPD ratios, in a number of invasive cervical cancers. Our aim was to investigate the association between these values and the clinicopathological features of invasive cervical cancer, including patient prognosis. Study design: Using enzyme-linked immunosorbent assays, the TP and DPD activities were quantitatively measured in 51 patients with cervical cancer who had also undergone a radical hysterectomy. Results: The TP, DPD and TP/DPD values in squamous cell carcinoma (SCC) were found to be significantly higher than the levels in non-SCC. Furthermore, in a SCC subgroup, the TP/DPD levels were significantly higher in cases where parametrial invasion was evident, and in a non-SCC subgroup, these levels were also significantly higher in cases with deep stromal invasion, lymph-vascular space invasion, large tumor size and parametrial invasion. The disease-free survival rate is shown to be significantly higher in patients with low TP/DPD levels indicating that this ratio may be associated with both the progression and recurrence of invasive cervical cancer. Conclusion: TP/DPD ratios may be associated with both the progression and recurrence of invasive cervical cancer.
KW - Cervical cancer
KW - Dihydropyrimidine dehydrogenase
KW - Thymidine phosphorylase
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U2 - 10.1016/j.ejogrb.2004.11.011
DO - 10.1016/j.ejogrb.2004.11.011
M3 - Article
C2 - 16259080
AN - SCOPUS:21244486568
SN - 0028-2243
VL - 121
SP - 81
EP - 85
JO - European Journal of Obstetrics and Gynecology and Reproductive Biology
JF - European Journal of Obstetrics and Gynecology and Reproductive Biology
IS - 1
ER -
