TY - JOUR
T1 - Prognostic significance of the controlling nutritional status (CONUT) score in patients with colorectal cancer
T2 - A systematic review and meta-analysis
AU - Takagi, Kosei
AU - Buettner, Stefan
AU - Ijzermans, Jan N.M.
N1 - Funding Information:
We express our gratitude to Wichor M. Bramer and Sabrina Gunput (Biomedical Information Specialists) from the Medical Library in Erasmus MC, Erasmus University Medical Center Rotterdam (Rotterdam, the Netherlands) for their involvement in the search term.
Publisher Copyright:
© 2020 IJS Publishing Group Ltd
PY - 2020/6
Y1 - 2020/6
N2 - Background: The clinical evidence of the controlling nutritional status (CONUT) score for outcomes has increased in gastroenterological surgical oncology. The aim of this study was to investigate the impact of the CONUT score on outcomes in patients with colorectal cancer (CRC). Methods: A literature review was systematically conducted to evaluate the significance of the CONUT score in CRC patients. Meta-analyses of survival were performed to investigate the effects of the CONUT score in CRC patients. Results: Nine studies met the inclusion criteria, and six studies with 2601 patients were included in the present meta-analyses. High CONUT score was associated with poor overall survival (HR 1.97, 95%CI = 1.40–2.77, P < 0.001), cancer-specific survival (HR 3.64, 95%CI = 1.96–6.75, P < 0.001), and recurrence/relapse-free survival (HR 1.68, 95%CI = 1.23–2.29, P = 0.001) after CRC surgery. Conclusions: The CONUT score is a practical prognostic factor associated with prognosis of CRC. Further studies are needed to clarify the significance of the CONUT score in CRC patients.
AB - Background: The clinical evidence of the controlling nutritional status (CONUT) score for outcomes has increased in gastroenterological surgical oncology. The aim of this study was to investigate the impact of the CONUT score on outcomes in patients with colorectal cancer (CRC). Methods: A literature review was systematically conducted to evaluate the significance of the CONUT score in CRC patients. Meta-analyses of survival were performed to investigate the effects of the CONUT score in CRC patients. Results: Nine studies met the inclusion criteria, and six studies with 2601 patients were included in the present meta-analyses. High CONUT score was associated with poor overall survival (HR 1.97, 95%CI = 1.40–2.77, P < 0.001), cancer-specific survival (HR 3.64, 95%CI = 1.96–6.75, P < 0.001), and recurrence/relapse-free survival (HR 1.68, 95%CI = 1.23–2.29, P = 0.001) after CRC surgery. Conclusions: The CONUT score is a practical prognostic factor associated with prognosis of CRC. Further studies are needed to clarify the significance of the CONUT score in CRC patients.
KW - Colorectal cancer
KW - Controlling nutritional status (CONUT) score
KW - Meta-analysis
KW - Outcome
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U2 - 10.1016/j.ijsu.2020.04.046
DO - 10.1016/j.ijsu.2020.04.046
M3 - Review article
C2 - 32335238
AN - SCOPUS:85083738581
SN - 1743-9191
VL - 78
SP - 91
EP - 96
JO - International Journal of Surgery
JF - International Journal of Surgery
ER -
