Prognostic significance of the controlling nutritional status (CONUT) score in patients with colorectal cancer: A systematic review and meta-analysis

Kosei Takagi, Stefan Buettner, Jan N.M. Ijzermans

Research output: Contribution to journalReview articlepeer-review

12 Citations (Scopus)

Abstract

Background: The clinical evidence of the controlling nutritional status (CONUT) score for outcomes has increased in gastroenterological surgical oncology. The aim of this study was to investigate the impact of the CONUT score on outcomes in patients with colorectal cancer (CRC). Methods: A literature review was systematically conducted to evaluate the significance of the CONUT score in CRC patients. Meta-analyses of survival were performed to investigate the effects of the CONUT score in CRC patients. Results: Nine studies met the inclusion criteria, and six studies with 2601 patients were included in the present meta-analyses. High CONUT score was associated with poor overall survival (HR 1.97, 95%CI = 1.40–2.77, P < 0.001), cancer-specific survival (HR 3.64, 95%CI = 1.96–6.75, P < 0.001), and recurrence/relapse-free survival (HR 1.68, 95%CI = 1.23–2.29, P = 0.001) after CRC surgery. Conclusions: The CONUT score is a practical prognostic factor associated with prognosis of CRC. Further studies are needed to clarify the significance of the CONUT score in CRC patients.

Original languageEnglish
Pages (from-to)91-96
Number of pages6
JournalInternational Journal of Surgery
Volume78
DOIs
Publication statusPublished - Jun 2020
Externally publishedYes

Keywords

  • Colorectal cancer
  • Controlling nutritional status (CONUT) score
  • Meta-analysis
  • Outcome

ASJC Scopus subject areas

  • Surgery

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