Prognostic significance of the BAALC isoform pattern and CEBPA mutations in pediatric acute myeloid leukemia with normal karyotype: A study by the Japanese Childhood AML Cooperative Study Group

Yasuhiro Mizushima, Tomohiko Taki, Akira Shimada, Yoshihiro Yui, Yoshimi Hiraumi, Hiroshi Matsubara, Motonobu Watanabe, Ken Ichiro Watanabe, Yuri Kamitsuji, Yasuhide Hayashi, Ichiro Tsukimoto, Ryoji Kobayashi, Keizo Horibe, Akio Tawa, Tatsutoshi Nakahata, Souichi Adachi

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9 Citations (Scopus)

Abstract

High BAALC (brain and acute leukemia, cytoplasmic) gene expression may indicate an adverse prognosis for adults who have acute myeloid leukemia (AML) and a normal karyotype, but its prognostic significance for pediatric AML cases is unclear. Whether different BAALC isoform patterns are of prognostic significance is also unclear. Newly diagnosed AML patients with normal karyotype who were treated by the Japanese Childhood AML Cooperative Treatment Protocol AML 99 were analyzed in terms of their BAALC expression levels (n = 29), BAALC isoforms (n = 29), and CEBPA mutations (n = 49). Eleven and 18 patients exhibited high and low BAALC expression, respectively, but these groups did not differ significantly in terms of overall survival (54.6 vs. 61.1%, P = 0.55) or event-free survival (61.4 vs. 50.0%, P = 0.82). Three of these 29 patients (10.3%) expressed the exon 1-5-6-8 BAALC isoform along with the expected 1-6-8 isoform and had adverse clinical outcomes. Novel CEBPA mutations were also identified in four of 49 patients (8.2%). All four patients have maintained complete remission for at least 5 years. Thus, 1-5-6-8 isoform expression may be associated with an adverse prognosis in pediatric AML with normal karyotype. CEBPA mutations may indicate a favorable prognosis.

Original languageEnglish
Pages (from-to)831-837
Number of pages7
JournalInternational journal of hematology
Volume91
Issue number5
DOIs
Publication statusPublished - Jun 2010
Externally publishedYes

Keywords

  • BAALC
  • CEBPA
  • Normal karyotype
  • Pediatric AML

ASJC Scopus subject areas

  • Hematology

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    Mizushima, Y., Taki, T., Shimada, A., Yui, Y., Hiraumi, Y., Matsubara, H., Watanabe, M., Watanabe, K. I., Kamitsuji, Y., Hayashi, Y., Tsukimoto, I., Kobayashi, R., Horibe, K., Tawa, A., Nakahata, T., & Adachi, S. (2010). Prognostic significance of the BAALC isoform pattern and CEBPA mutations in pediatric acute myeloid leukemia with normal karyotype: A study by the Japanese Childhood AML Cooperative Study Group. International journal of hematology, 91(5), 831-837. https://doi.org/10.1007/s12185-010-0585-x