Prognostic significance of syndecan-1 expression in human endometrial cancer

Hasengaowa, J. Kodama, T. Kusumoto, Y. Shinyo, N. Seki, Y. Hiramatsu

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Background: Syndecan-1 binds to various extracellular matrix components via its heparan sulfate glycosaminoglycans. The aim of this study was to investigate syndecan-1 expression in endometrial cancers. Patients and methods: We investigated the expression of the syndecan-1 core protein by immunohistochemistry in 109 endometrial cancers, and analyzed correlation with various clinicopathological features, including patient outcome. Results: Epithelial syndecan-1 expression was significantly lower in advanced stage, high grade, deep myometrial invasion, cervical involvement, lymph node metastasis, lymph vascular space involvement and positive peritoneal cytology. Stromal syndecan-1 expression was significantly higher in high-grade tumors. The disease-free and overall survival rates of patients exhibiting both low epithelial and high stromal syndecan-1 expression was poor. Multivariate analysis showed that high stromal syndecan-1 expression was an independent prognostic factor for both disease-free and overall survival. Low epithelial syndecan-1 expression was a prognostic factor only in the univariate analysis. Conclusions: Loss of epithelial syndecan-1 and induction of stromal syndecan-1 expression may be associated with tumor progression. Stromal syndecan-1 expression can serve as an indicator of poor prognosis in patients with endometrial cancer.

Original languageEnglish
Pages (from-to)1109-1115
Number of pages7
JournalAnnals of Oncology
Volume16
Issue number7
DOIs
Publication statusPublished - Jul 2005

Keywords

  • Endometrial cancer
  • Prognosis
  • Syndecan-1

ASJC Scopus subject areas

  • Hematology
  • Oncology

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    Hasengaowa, Kodama, J., Kusumoto, T., Shinyo, Y., Seki, N., & Hiramatsu, Y. (2005). Prognostic significance of syndecan-1 expression in human endometrial cancer. Annals of Oncology, 16(7), 1109-1115. https://doi.org/10.1093/annonc/mdi224