Abstract
Background: The prognostic value of p21 protein expression in lung cancer patients has been assessed. However, its significance in those with pulmonary squamous cell carcinoma following induction chemotherapy (IC) remains unclear. We studied on patients who did or did not undergo IC (NIC) to elucidate the prognostic value of p21 protein expression. Materials and Methods: p21 protein expression was assessed immunohistochemically and samples with greater than 10% positive tumor cells were considered positive. We then analyzed clinicalpathological features, including p53 protein expression and prognosis, in 43 patients who underwent IC group and 40 who did not IC (NIC) group. Results: Positive nuclear p21 samples were obtained from 17 (41.5%) patients in the in IC group and 22 (55.0%) in the NIC group. In the IC group, there was no significant correlation between the histological effectiveness of chemotherapy and p53 protein expression, whereas a significant correlation was observed between that and p21 protein expression (p=0.048). Further, the prognosis for p21-positive patients tended to be better (p=0.0506) than for p21-negative patients, and was significant (p=0.048) in patients with pathological stage (p-stage) II or III disease. Conclusion: Our findings suggest that p21 protein expression is a prognostic factor for primary patients with pulmonary squamous cell carcinoma following IC.
| Original language | English |
|---|---|
| Pages (from-to) | 9-14 |
| Number of pages | 6 |
| Journal | Annals of Thoracic and Cardiovascular Surgery |
| Volume | 13 |
| Issue number | 1 |
| Publication status | Published - Feb 2007 |
| Externally published | Yes |
Fingerprint
Keywords
- Induction chemotherapy
- Lung cancer
- p21
- p53
- Squamous cell carcinoma
ASJC Scopus subject areas
- Surgery
- Cardiology and Cardiovascular Medicine
- Pulmonary and Respiratory Medicine
- Gastroenterology
- Medicine(all)
Cite this
Prognostic significance of p21 protein expression in patients with pulmonary squamous cell carcinoma following induction chemotherapy. / Tamura, Motohiko; Sawabata, Noriyoshi; Kobayashi, Satoru; Umezu, Hideo; Seki, Norio; Yoshii, Naoko; Karube, Yoko; Araki, Osamu; Ishihama, Hidemi; Nagai, Senkaku; Miyoshi, Shinichiro.
In: Annals of Thoracic and Cardiovascular Surgery, Vol. 13, No. 1, 02.2007, p. 9-14.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Prognostic significance of p21 protein expression in patients with pulmonary squamous cell carcinoma following induction chemotherapy
AU - Tamura, Motohiko
AU - Sawabata, Noriyoshi
AU - Kobayashi, Satoru
AU - Umezu, Hideo
AU - Seki, Norio
AU - Yoshii, Naoko
AU - Karube, Yoko
AU - Araki, Osamu
AU - Ishihama, Hidemi
AU - Nagai, Senkaku
AU - Miyoshi, Shinichiro
PY - 2007/2
Y1 - 2007/2
N2 - Background: The prognostic value of p21 protein expression in lung cancer patients has been assessed. However, its significance in those with pulmonary squamous cell carcinoma following induction chemotherapy (IC) remains unclear. We studied on patients who did or did not undergo IC (NIC) to elucidate the prognostic value of p21 protein expression. Materials and Methods: p21 protein expression was assessed immunohistochemically and samples with greater than 10% positive tumor cells were considered positive. We then analyzed clinicalpathological features, including p53 protein expression and prognosis, in 43 patients who underwent IC group and 40 who did not IC (NIC) group. Results: Positive nuclear p21 samples were obtained from 17 (41.5%) patients in the in IC group and 22 (55.0%) in the NIC group. In the IC group, there was no significant correlation between the histological effectiveness of chemotherapy and p53 protein expression, whereas a significant correlation was observed between that and p21 protein expression (p=0.048). Further, the prognosis for p21-positive patients tended to be better (p=0.0506) than for p21-negative patients, and was significant (p=0.048) in patients with pathological stage (p-stage) II or III disease. Conclusion: Our findings suggest that p21 protein expression is a prognostic factor for primary patients with pulmonary squamous cell carcinoma following IC.
AB - Background: The prognostic value of p21 protein expression in lung cancer patients has been assessed. However, its significance in those with pulmonary squamous cell carcinoma following induction chemotherapy (IC) remains unclear. We studied on patients who did or did not undergo IC (NIC) to elucidate the prognostic value of p21 protein expression. Materials and Methods: p21 protein expression was assessed immunohistochemically and samples with greater than 10% positive tumor cells were considered positive. We then analyzed clinicalpathological features, including p53 protein expression and prognosis, in 43 patients who underwent IC group and 40 who did not IC (NIC) group. Results: Positive nuclear p21 samples were obtained from 17 (41.5%) patients in the in IC group and 22 (55.0%) in the NIC group. In the IC group, there was no significant correlation between the histological effectiveness of chemotherapy and p53 protein expression, whereas a significant correlation was observed between that and p21 protein expression (p=0.048). Further, the prognosis for p21-positive patients tended to be better (p=0.0506) than for p21-negative patients, and was significant (p=0.048) in patients with pathological stage (p-stage) II or III disease. Conclusion: Our findings suggest that p21 protein expression is a prognostic factor for primary patients with pulmonary squamous cell carcinoma following IC.
KW - Induction chemotherapy
KW - Lung cancer
KW - p21
KW - p53
KW - Squamous cell carcinoma
UR - http://www.scopus.com/inward/record.url?scp=34447294290&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34447294290&partnerID=8YFLogxK
M3 - Article
C2 - 17392664
AN - SCOPUS:34447294290
VL - 13
SP - 9
EP - 14
JO - Annals of Thoracic and Cardiovascular Surgery
JF - Annals of Thoracic and Cardiovascular Surgery
SN - 1341-1098
IS - 1
ER -