Prognostic significance of mutant p53 protein, p-glycoprotein and glutathione S-transferase-π in patients with unresectable non-small cell lung cancer

Kazuyo Miyatake, Kenichi Gemba, Hiroshi Ueoka, Kenji Nishii, Katsuyuki Kiura, Masahiro Tabata, Takuo Shibayama, Nagio Takigawa, Masashi Kawaraya, Mitsune Tanimoto

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21 Citations (Scopus)

Abstract

Background: The prognostic significance of mutant p53 protein, p-glycoprotein (P-gp) and glutathione S-transferase-π (GST-π) in patients with unresectable non-small cell lung cancer (NSCLC) has not been established. Materials and Methods: We performed immunohistochemical staining of p53, P-gp and GST-π using transbronchial biopsy specimens obtained from previously untreated NSCLC patients. Results: Of 45 patients examined, p53 immunostaining was positive in 18 (40%) patients. The objective response rate by cisplatin (CDDP)-based chemotherapy was significantly lower in patients with p53-positive tumors compared to those with p53-negative tumors (22% versus 59%, p=0.0143). Survival of the patients with p53-positive tumors was significantly shorter than those with p53-negative tumors (median survival time: 4.6 months versus 12.2 months, p=0.011), which was confirmed by the multivariate analysis (p=0.0243). However, P-gp and GST-π showed no significant relationship with either response rate or survival in patients with unresectable NSCLC receiving CDDP-based chemotherapy. Conclusion: p53 alteration is an independent and significant indicator to predict unfavorable prognosis in patients with unresectable NSCLC.

Original languageEnglish
Pages (from-to)2829-2836
Number of pages8
JournalAnticancer research
Volume23
Issue number3 C
Publication statusPublished - May 1 2003

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Keywords

  • Glutathione S-transferase-π
  • Non-small cell lung cancer
  • P-glycoprotein
  • P53
  • Prognostic factor

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Miyatake, K., Gemba, K., Ueoka, H., Nishii, K., Kiura, K., Tabata, M., Shibayama, T., Takigawa, N., Kawaraya, M., & Tanimoto, M. (2003). Prognostic significance of mutant p53 protein, p-glycoprotein and glutathione S-transferase-π in patients with unresectable non-small cell lung cancer. Anticancer research, 23(3 C), 2829-2836.