Prognostic significance of heat shock protein 27 (HSP27) in patients with oral squamous cell carcinoma

Hiroshi Mese, Akira Sasaki, Shuko Nakayama, Norie Yoshioka, Yasuto Yoshihama, Koji Kishimoto, Tomohiro Matsumura

Research output: Contribution to journalArticlepeer-review

44 Citations (Scopus)


Heat shock proteins (HSPs) have been defined as proteins induced by heat shock and other environmental and pathophysiologic stress. Heat shock protein 27 (HSP27) is one of the small heat shock proteins. HSP27 is implicated in protein-protein interactions such as folding, translocation, and prevention of inappropriate protein aggregation. Many of their functions suggest that they play important roles in cancers. Archival tissues from 40 patients with oral squamous cell carcinoma who received primary surgical resection were examined for HSP27 by immunohistochemistry and correlated with clinical stage, lymph node metastasis, histological grade and survival period. HSP27 expression was positive staining (+) in 20 (50%), weak or negative staining (-) in 20 (50%) of total 40 cases. There was no correlation between HSP27 expression and clinical stage, lymph node metastasis and histological grade. However, when compared with clinicopathological features, the expression of HSP27 correlated inversely with survival period. This study suggests that the expression of HSP27 is frequently promoted in patients with oral squamous cell carcinoma and should be considered an independent prognostic factor of oral squamous cell carcinoma patients.

Original languageEnglish
Pages (from-to)341-344
Number of pages4
JournalOncology reports
Issue number2
Publication statusPublished - Mar 2002


  • Heat shock protein 27 (HSP27)
  • Oral squamous cell carcinoma
  • Prognosis factor

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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