Prognostic significance of elevated cyclooxygenase 2 expression in primary, resected lung adenocarcinomas

Hiroyuki Achiwa, Yasushi Yatabe, Toyoaki Hida, Tetsuo Kuroishi, Ken Ichi Kozaki, Shigeo Nakamura, Makoto Ogawa, Takahiko Sugiura, Tetsuya Mitsudomi, Takashi Takahashi

Research output: Contribution to journalArticlepeer-review

309 Citations (Scopus)


Recently, we demonstrated that elevated expression of cyclooxygenase 2 (COX-2) is frequently seen in a specific type of lung cancer, i.e., adenocarcinoma, and is possibly associated with its invasion and metastasis. Here, the prognostic significance of elevated COX-2 expression was evaluated in a cohort of 130 adenocarcinoma patients who had consecutively undergone potentially curative resections. Immunohistological examination showed the presence of tumor cells with markedly increased COX-2 immunoreactivity in 93 of 130 (72%) cases. No relationship was found between the increase in COX-2 expression and clinical outcomes when the entire cohort was considered (P = 0.099). Reasoning that the influence of the increase in COX-2 expression may have been obscured by the clinical and molecular pathogenetic complexities in cases with an advanced disease, we also separately analyzed the prognostic significance of increased COX-2 expression after stratification according to the disease stage. A significant relationship between elevated COX-2 expression and shortened patient survival was observed only in a cohort of patients with stage I disease (P = 0.034). These findings suggest that an increase in COX-2 expression may be clinically significant for the prognosis of patients undergoing surgical resection of early-stage adenocarcinomas and, thus, warrant further conclusive studies involving a larger cohort.

Original languageEnglish
Pages (from-to)1001-1005
Number of pages5
JournalClinical Cancer Research
Issue number5
Publication statusPublished - May 1999
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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