Prognostic importance of fucosylated alpha-fetoprotein in hepatocellular carcinoma patients with low alpha-fetoprotein

Kazuhiro Nouso, Yoshiyuki Kobayashi, Shinichiro Nakamura, Sayo Kobayashi, Hiroki Takayama, Junichi Toshimori, Kenji Kuwaki, Hiroaki Hagihara, Hideki Ohnishi, Yasuhiro Miyake, Fusao Ikeda, Hidenori Shiraha, Akinobu Takaki, Yoshiaki Iwasaki, Haruhiko Kobashi, Kazuhide Yamamoto

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Background and Aim: Fucosylated alpha-fetoprotein (AFP-L3) is known to be a marker of poor prognosis in patients with hepatocellular carcinoma (HCC). However, it has been difficult to measure AFP-L3 under low AFP (≤20ng/mL). The aim of this study was to elucidate the role of AFP-L3 in HCC patients with low AFP conditions. Methods: One hundred and ninety six consecutive newly developed HCC patients with low AFP (≤20ng/mL) were examined for serum AFP-L3 expression by a newly-developed micro-total analysis system that could stably measure AFP-L3 in low AFP circumstances, and its clinical importance was analyzed. Results: Positivity of AFP-L3 in HCC patients was 13.3% at a cut-off level of 10%. Five-year survivals of HCC patients with AFP-L3 (

Original languageEnglish
Pages (from-to)1195-1200
Number of pages6
JournalJournal of Gastroenterology and Hepatology (Australia)
Volume26
Issue number7
DOIs
Publication statusPublished - 2011

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alpha-Fetoproteins
Hepatocellular Carcinoma
Survival
Serum

Keywords

  • Alpha-fetoprotein
  • Fucosylation
  • Hepatocellular carcinoma

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

Cite this

Prognostic importance of fucosylated alpha-fetoprotein in hepatocellular carcinoma patients with low alpha-fetoprotein. / Nouso, Kazuhiro; Kobayashi, Yoshiyuki; Nakamura, Shinichiro; Kobayashi, Sayo; Takayama, Hiroki; Toshimori, Junichi; Kuwaki, Kenji; Hagihara, Hiroaki; Ohnishi, Hideki; Miyake, Yasuhiro; Ikeda, Fusao; Shiraha, Hidenori; Takaki, Akinobu; Iwasaki, Yoshiaki; Kobashi, Haruhiko; Yamamoto, Kazuhide.

In: Journal of Gastroenterology and Hepatology (Australia), Vol. 26, No. 7, 2011, p. 1195-1200.

Research output: Contribution to journalArticle

Nouso, K, Kobayashi, Y, Nakamura, S, Kobayashi, S, Takayama, H, Toshimori, J, Kuwaki, K, Hagihara, H, Ohnishi, H, Miyake, Y, Ikeda, F, Shiraha, H, Takaki, A, Iwasaki, Y, Kobashi, H & Yamamoto, K 2011, 'Prognostic importance of fucosylated alpha-fetoprotein in hepatocellular carcinoma patients with low alpha-fetoprotein', Journal of Gastroenterology and Hepatology (Australia), vol. 26, no. 7, pp. 1195-1200. https://doi.org/10.1111/j.1440-1746.2011.06720.x
Nouso, Kazuhiro ; Kobayashi, Yoshiyuki ; Nakamura, Shinichiro ; Kobayashi, Sayo ; Takayama, Hiroki ; Toshimori, Junichi ; Kuwaki, Kenji ; Hagihara, Hiroaki ; Ohnishi, Hideki ; Miyake, Yasuhiro ; Ikeda, Fusao ; Shiraha, Hidenori ; Takaki, Akinobu ; Iwasaki, Yoshiaki ; Kobashi, Haruhiko ; Yamamoto, Kazuhide. / Prognostic importance of fucosylated alpha-fetoprotein in hepatocellular carcinoma patients with low alpha-fetoprotein. In: Journal of Gastroenterology and Hepatology (Australia). 2011 ; Vol. 26, No. 7. pp. 1195-1200.
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