Prognostic impact of salvage treatment on hearing recovery in patients with sudden sensorineural hearing loss refractory to systemic corticosteroids: A retrospective observational study

Takayuki Nakagawa, Michio Yamamoto, Kozo Kumakawa, Shin Ichi Usami, Naohito Hato, Keiji Tabuchi, Mariko Takahashi, Keizo Fujiwara, Akira Sasaki, Shizuo Komune, Norio Yamamoto, Harukazu Hiraumi, Tatsunori Sakamoto, Akira Shimizu, Juichi Ito

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Objective: To determine the prognostic factors for hearing recovery in patients with sudden sensorineural hearing loss (SSHL) refractory to systemic corticosteroids following salvage treatment. Methods: This is a retrospective observational study at nine tertiary referral hospitals. A total of 120 patients with sudden deafness refractory to systemic corticosteroids were enrolled. The patients were randomly assigned to receive topical application of recombinant human IGF-1 or intratympanic injection of dexamethasone as salvage treatment. Multiple regression analysis was performed to identify determinants of hearing recovery using pure tone audiometry results at 8 weeks after treatment. Clinical predictors that were evaluated included age, sex, pretreatment hearing level, presence of vertiginous symptoms, days to study entry from symptom onset and salvage treatment assignment (IGF-1 vs. dexamethasone). Results: The linear regression model identified age (P = 0.001), pretreatment hearing level (P < 0.001), days to study entry from symptom onset (P = 0.011) and treatment assignment (P = 0.033) at 8 weeks after treatment as significant variables influencing the recovery of pure tone audiometry average thresholds. Younger age (<60 years), early initiation of salvage treatment and treatment with topical IGF-1 therapy had significant effects on hearing recovery. Conclusion: The results indicate that early initiation and choice of treatment modalities for salvage treatment may be important for the prognosis of patients with refractory SSHL. The positive effect of topical IGF-1 therapy on hearing recovery indicates its utility as salvage treatment.

Original languageEnglish
Pages (from-to)489-494
Number of pages6
JournalAuris Nasus Larynx
Volume43
Issue number5
DOIs
Publication statusPublished - Oct 1 2016
Externally publishedYes

Fingerprint

Sudden Hearing Loss
Salvage Therapy
Sensorineural Hearing Loss
Hearing
Observational Studies
Adrenal Cortex Hormones
Retrospective Studies
Insulin-Like Growth Factor I
Pure-Tone Audiometry
Dexamethasone
Therapeutics
Linear Models
Tertiary Care Centers
Regression Analysis

Keywords

  • Drug delivery system
  • Insulin-like growth factor 1
  • Local application
  • Multiple regression analysis
  • Sudden sensorineural hearing loss

ASJC Scopus subject areas

  • Surgery
  • Otorhinolaryngology

Cite this

Prognostic impact of salvage treatment on hearing recovery in patients with sudden sensorineural hearing loss refractory to systemic corticosteroids : A retrospective observational study. / Nakagawa, Takayuki; Yamamoto, Michio; Kumakawa, Kozo; Usami, Shin Ichi; Hato, Naohito; Tabuchi, Keiji; Takahashi, Mariko; Fujiwara, Keizo; Sasaki, Akira; Komune, Shizuo; Yamamoto, Norio; Hiraumi, Harukazu; Sakamoto, Tatsunori; Shimizu, Akira; Ito, Juichi.

In: Auris Nasus Larynx, Vol. 43, No. 5, 01.10.2016, p. 489-494.

Research output: Contribution to journalArticle

Nakagawa, T, Yamamoto, M, Kumakawa, K, Usami, SI, Hato, N, Tabuchi, K, Takahashi, M, Fujiwara, K, Sasaki, A, Komune, S, Yamamoto, N, Hiraumi, H, Sakamoto, T, Shimizu, A & Ito, J 2016, 'Prognostic impact of salvage treatment on hearing recovery in patients with sudden sensorineural hearing loss refractory to systemic corticosteroids: A retrospective observational study', Auris Nasus Larynx, vol. 43, no. 5, pp. 489-494. https://doi.org/10.1016/j.anl.2015.12.004
Nakagawa, Takayuki ; Yamamoto, Michio ; Kumakawa, Kozo ; Usami, Shin Ichi ; Hato, Naohito ; Tabuchi, Keiji ; Takahashi, Mariko ; Fujiwara, Keizo ; Sasaki, Akira ; Komune, Shizuo ; Yamamoto, Norio ; Hiraumi, Harukazu ; Sakamoto, Tatsunori ; Shimizu, Akira ; Ito, Juichi. / Prognostic impact of salvage treatment on hearing recovery in patients with sudden sensorineural hearing loss refractory to systemic corticosteroids : A retrospective observational study. In: Auris Nasus Larynx. 2016 ; Vol. 43, No. 5. pp. 489-494.
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abstract = "Objective: To determine the prognostic factors for hearing recovery in patients with sudden sensorineural hearing loss (SSHL) refractory to systemic corticosteroids following salvage treatment. Methods: This is a retrospective observational study at nine tertiary referral hospitals. A total of 120 patients with sudden deafness refractory to systemic corticosteroids were enrolled. The patients were randomly assigned to receive topical application of recombinant human IGF-1 or intratympanic injection of dexamethasone as salvage treatment. Multiple regression analysis was performed to identify determinants of hearing recovery using pure tone audiometry results at 8 weeks after treatment. Clinical predictors that were evaluated included age, sex, pretreatment hearing level, presence of vertiginous symptoms, days to study entry from symptom onset and salvage treatment assignment (IGF-1 vs. dexamethasone). Results: The linear regression model identified age (P = 0.001), pretreatment hearing level (P < 0.001), days to study entry from symptom onset (P = 0.011) and treatment assignment (P = 0.033) at 8 weeks after treatment as significant variables influencing the recovery of pure tone audiometry average thresholds. Younger age (<60 years), early initiation of salvage treatment and treatment with topical IGF-1 therapy had significant effects on hearing recovery. Conclusion: The results indicate that early initiation and choice of treatment modalities for salvage treatment may be important for the prognosis of patients with refractory SSHL. The positive effect of topical IGF-1 therapy on hearing recovery indicates its utility as salvage treatment.",
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T2 - A retrospective observational study

AU - Nakagawa, Takayuki

AU - Yamamoto, Michio

AU - Kumakawa, Kozo

AU - Usami, Shin Ichi

AU - Hato, Naohito

AU - Tabuchi, Keiji

AU - Takahashi, Mariko

AU - Fujiwara, Keizo

AU - Sasaki, Akira

AU - Komune, Shizuo

AU - Yamamoto, Norio

AU - Hiraumi, Harukazu

AU - Sakamoto, Tatsunori

AU - Shimizu, Akira

AU - Ito, Juichi

PY - 2016/10/1

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N2 - Objective: To determine the prognostic factors for hearing recovery in patients with sudden sensorineural hearing loss (SSHL) refractory to systemic corticosteroids following salvage treatment. Methods: This is a retrospective observational study at nine tertiary referral hospitals. A total of 120 patients with sudden deafness refractory to systemic corticosteroids were enrolled. The patients were randomly assigned to receive topical application of recombinant human IGF-1 or intratympanic injection of dexamethasone as salvage treatment. Multiple regression analysis was performed to identify determinants of hearing recovery using pure tone audiometry results at 8 weeks after treatment. Clinical predictors that were evaluated included age, sex, pretreatment hearing level, presence of vertiginous symptoms, days to study entry from symptom onset and salvage treatment assignment (IGF-1 vs. dexamethasone). Results: The linear regression model identified age (P = 0.001), pretreatment hearing level (P < 0.001), days to study entry from symptom onset (P = 0.011) and treatment assignment (P = 0.033) at 8 weeks after treatment as significant variables influencing the recovery of pure tone audiometry average thresholds. Younger age (<60 years), early initiation of salvage treatment and treatment with topical IGF-1 therapy had significant effects on hearing recovery. Conclusion: The results indicate that early initiation and choice of treatment modalities for salvage treatment may be important for the prognosis of patients with refractory SSHL. The positive effect of topical IGF-1 therapy on hearing recovery indicates its utility as salvage treatment.

AB - Objective: To determine the prognostic factors for hearing recovery in patients with sudden sensorineural hearing loss (SSHL) refractory to systemic corticosteroids following salvage treatment. Methods: This is a retrospective observational study at nine tertiary referral hospitals. A total of 120 patients with sudden deafness refractory to systemic corticosteroids were enrolled. The patients were randomly assigned to receive topical application of recombinant human IGF-1 or intratympanic injection of dexamethasone as salvage treatment. Multiple regression analysis was performed to identify determinants of hearing recovery using pure tone audiometry results at 8 weeks after treatment. Clinical predictors that were evaluated included age, sex, pretreatment hearing level, presence of vertiginous symptoms, days to study entry from symptom onset and salvage treatment assignment (IGF-1 vs. dexamethasone). Results: The linear regression model identified age (P = 0.001), pretreatment hearing level (P < 0.001), days to study entry from symptom onset (P = 0.011) and treatment assignment (P = 0.033) at 8 weeks after treatment as significant variables influencing the recovery of pure tone audiometry average thresholds. Younger age (<60 years), early initiation of salvage treatment and treatment with topical IGF-1 therapy had significant effects on hearing recovery. Conclusion: The results indicate that early initiation and choice of treatment modalities for salvage treatment may be important for the prognosis of patients with refractory SSHL. The positive effect of topical IGF-1 therapy on hearing recovery indicates its utility as salvage treatment.

KW - Drug delivery system

KW - Insulin-like growth factor 1

KW - Local application

KW - Multiple regression analysis

KW - Sudden sensorineural hearing loss

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