Prognostic factors influencing survival after nephroureterectomy for transitional cell carcinoma of the upper urinary tract

Yasuyuki Kobayashi, Takashi Saika, Daisuke Manabe, Yasutomo Nasu, Hiromi Kumon

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3 Citations (Scopus)


We analyzed the prognostic factors influencing survival after surgeries for upper urinary tract urothelial carcinoma (UUT-UC) with longer follow-up periods than in previous studies. Between January 2000 and December 2004, 386 patients underwent nephroureterectomy for UUT-UC. The data for the 221 patients with UUT-UC were retrospectively reviewed. Nine variables were evaluated for association with the survival outcomes of cause-specific survival. The prognostic significance was tested univariately with the log-rank test. The simultaneous effects of multiple prognostic factors were estimated by multiple regression analysis using the Cox proportional hazards model. The median follow-up was 38.4 months. The 5-year over all survival was 62.3%. Significant prognostic factors for disease-specific survival rate on univariate analysis were pathological stage (p < 0.0001), tumor grade (p = 0.0324), and venous invasion (p < 0.0001). Multivariate analysis revealed that only venous invasion was significant for disease-specific survival rate (p = 0.0205). Venous invasion was the only independent prognostic factor in pathologically localized UUT-UC.

Original languageEnglish
Pages (from-to)27-31
Number of pages5
JournalActa medica Okayama
Issue number1
Publication statusPublished - Jun 10 2010



  • Nephroureterectomy
  • Transitional cell carcinoma
  • Upper urinary tract

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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