Prognostic factors influencing survival after nephroureterectomy for transitional cell carcinoma of the upper urinary tract

Yasuyuki Kobayashi, Takashi Saika, Daisuke Manabe, Yasutomo Nasu, Hiromi Kumon

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We analyzed the prognostic factors influencing survival after surgeries for upper urinary tract urothelial carcinoma (UUT-UC) with longer follow-up periods than in previous studies. Between January 2000 and December 2004, 386 patients underwent nephroureterectomy for UUT-UC. The data for the 221 patients with UUT-UC were retrospectively reviewed. Nine variables were evaluated for association with the survival outcomes of cause-specific survival. The prognostic significance was tested univariately with the log-rank test. The simultaneous effects of multiple prognostic factors were estimated by multiple regression analysis using the Cox proportional hazards model. The median follow-up was 38.4 months. The 5-year over all survival was 62.3%. Significant prognostic factors for disease-specific survival rate on univariate analysis were pathological stage (p <0.0001), tumor grade (p = 0.0324), and venous invasion (p <0.0001). Multivariate analysis revealed that only venous invasion was significant for disease-specific survival rate (p = 0.0205). Venous invasion was the only independent prognostic factor in pathologically localized UUT-UC.

Original languageEnglish
Pages (from-to)27-31
Number of pages5
JournalActa Medica Okayama
Volume64
Issue number1
Publication statusPublished - 2010

Fingerprint

Transitional Cell Carcinoma
Urinary Tract
Cells
Carcinoma
Survival
Regression analysis
Surgery
Tumors
Hazards
Survival Rate
Proportional Hazards Models
Multivariate Analysis
Regression Analysis
Neoplasms

Keywords

  • Nephroureterectomy
  • Transitional cell carcinoma
  • Upper urinary tract

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Prognostic factors influencing survival after nephroureterectomy for transitional cell carcinoma of the upper urinary tract. / Kobayashi, Yasuyuki; Saika, Takashi; Manabe, Daisuke; Nasu, Yasutomo; Kumon, Hiromi.

In: Acta Medica Okayama, Vol. 64, No. 1, 2010, p. 27-31.

Research output: Contribution to journalArticle

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