Prognostic factors in patients with submucosal esophageal cancer

Shoji Natsugoe, Masataka Matsumoto, Hiroshi Okumura, Masanori Ikeda, Sumiya Ishigami, Tetsuhiro Owaki, Sonshin Takao, Takashi Aikou

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

The detection rate of early-stage esophageal cancer has increased recently. Various types of treatment including endoscopic mucosal resection, blunt dissection, and esophagectomy with extended lymphadenectomy are employed in patients with submucosal esophageal cancer. The purpose of the present study was to analyze prognostic factors in patients with submucosal esophageal cancer. Univariate analysis showed that lymph node metastasis, subdivision of tumor depth, and lymphatic invasion were correlated with prognosis, whereas sex, age, tumor location, surgical procedure, adjuvant therapy, histologic findings, and venous invasion did not affect prognosis. Multivariate analysis demonstrated lymph node metastasis to be the only significant prognostic factor in submucosal esophageal cancer. Although subdivisions of tumor depth did not reach significance as prognostic factors, lymph node metastasis was strongly related to tumor depth. To select the individualized treatment in patients with submucosal esophageal cancer, accurate diagnosis of lymph node metastasis necessitates a combination of imaging methods such as endoscopic ultrasound-guided fine-needle aspiration, computed tomography, and positron emission tomography.

Original languageEnglish
Pages (from-to)631-635
Number of pages5
JournalJournal of Gastrointestinal Surgery
Volume8
Issue number5
DOIs
Publication statusPublished - Jul 1 2004
Externally publishedYes

Fingerprint

Esophageal Neoplasms
Lymph Nodes
Neoplasm Metastasis
Neoplasms
Endoscopic Ultrasound-Guided Fine Needle Aspiration
Esophagectomy
Lymph Node Excision
Dissection
Therapeutics
Multivariate Analysis

Keywords

  • Esophageal cancer
  • lymph node metastasis
  • submucosal invasion

ASJC Scopus subject areas

  • Surgery
  • Gastroenterology

Cite this

Natsugoe, S., Matsumoto, M., Okumura, H., Ikeda, M., Ishigami, S., Owaki, T., ... Aikou, T. (2004). Prognostic factors in patients with submucosal esophageal cancer. Journal of Gastrointestinal Surgery, 8(5), 631-635. https://doi.org/10.1016/j.gassur.2004.02.004

Prognostic factors in patients with submucosal esophageal cancer. / Natsugoe, Shoji; Matsumoto, Masataka; Okumura, Hiroshi; Ikeda, Masanori; Ishigami, Sumiya; Owaki, Tetsuhiro; Takao, Sonshin; Aikou, Takashi.

In: Journal of Gastrointestinal Surgery, Vol. 8, No. 5, 01.07.2004, p. 631-635.

Research output: Contribution to journalArticle

Natsugoe, S, Matsumoto, M, Okumura, H, Ikeda, M, Ishigami, S, Owaki, T, Takao, S & Aikou, T 2004, 'Prognostic factors in patients with submucosal esophageal cancer', Journal of Gastrointestinal Surgery, vol. 8, no. 5, pp. 631-635. https://doi.org/10.1016/j.gassur.2004.02.004
Natsugoe S, Matsumoto M, Okumura H, Ikeda M, Ishigami S, Owaki T et al. Prognostic factors in patients with submucosal esophageal cancer. Journal of Gastrointestinal Surgery. 2004 Jul 1;8(5):631-635. https://doi.org/10.1016/j.gassur.2004.02.004
Natsugoe, Shoji ; Matsumoto, Masataka ; Okumura, Hiroshi ; Ikeda, Masanori ; Ishigami, Sumiya ; Owaki, Tetsuhiro ; Takao, Sonshin ; Aikou, Takashi. / Prognostic factors in patients with submucosal esophageal cancer. In: Journal of Gastrointestinal Surgery. 2004 ; Vol. 8, No. 5. pp. 631-635.
@article{d8e1892fd9004e63b2e28d8aa78d8eca,
title = "Prognostic factors in patients with submucosal esophageal cancer",
abstract = "The detection rate of early-stage esophageal cancer has increased recently. Various types of treatment including endoscopic mucosal resection, blunt dissection, and esophagectomy with extended lymphadenectomy are employed in patients with submucosal esophageal cancer. The purpose of the present study was to analyze prognostic factors in patients with submucosal esophageal cancer. Univariate analysis showed that lymph node metastasis, subdivision of tumor depth, and lymphatic invasion were correlated with prognosis, whereas sex, age, tumor location, surgical procedure, adjuvant therapy, histologic findings, and venous invasion did not affect prognosis. Multivariate analysis demonstrated lymph node metastasis to be the only significant prognostic factor in submucosal esophageal cancer. Although subdivisions of tumor depth did not reach significance as prognostic factors, lymph node metastasis was strongly related to tumor depth. To select the individualized treatment in patients with submucosal esophageal cancer, accurate diagnosis of lymph node metastasis necessitates a combination of imaging methods such as endoscopic ultrasound-guided fine-needle aspiration, computed tomography, and positron emission tomography.",
keywords = "Esophageal cancer, lymph node metastasis, submucosal invasion",
author = "Shoji Natsugoe and Masataka Matsumoto and Hiroshi Okumura and Masanori Ikeda and Sumiya Ishigami and Tetsuhiro Owaki and Sonshin Takao and Takashi Aikou",
year = "2004",
month = "7",
day = "1",
doi = "10.1016/j.gassur.2004.02.004",
language = "English",
volume = "8",
pages = "631--635",
journal = "Journal of Gastrointestinal Surgery",
issn = "1091-255X",
publisher = "Springer New York",
number = "5",

}

TY - JOUR

T1 - Prognostic factors in patients with submucosal esophageal cancer

AU - Natsugoe, Shoji

AU - Matsumoto, Masataka

AU - Okumura, Hiroshi

AU - Ikeda, Masanori

AU - Ishigami, Sumiya

AU - Owaki, Tetsuhiro

AU - Takao, Sonshin

AU - Aikou, Takashi

PY - 2004/7/1

Y1 - 2004/7/1

N2 - The detection rate of early-stage esophageal cancer has increased recently. Various types of treatment including endoscopic mucosal resection, blunt dissection, and esophagectomy with extended lymphadenectomy are employed in patients with submucosal esophageal cancer. The purpose of the present study was to analyze prognostic factors in patients with submucosal esophageal cancer. Univariate analysis showed that lymph node metastasis, subdivision of tumor depth, and lymphatic invasion were correlated with prognosis, whereas sex, age, tumor location, surgical procedure, adjuvant therapy, histologic findings, and venous invasion did not affect prognosis. Multivariate analysis demonstrated lymph node metastasis to be the only significant prognostic factor in submucosal esophageal cancer. Although subdivisions of tumor depth did not reach significance as prognostic factors, lymph node metastasis was strongly related to tumor depth. To select the individualized treatment in patients with submucosal esophageal cancer, accurate diagnosis of lymph node metastasis necessitates a combination of imaging methods such as endoscopic ultrasound-guided fine-needle aspiration, computed tomography, and positron emission tomography.

AB - The detection rate of early-stage esophageal cancer has increased recently. Various types of treatment including endoscopic mucosal resection, blunt dissection, and esophagectomy with extended lymphadenectomy are employed in patients with submucosal esophageal cancer. The purpose of the present study was to analyze prognostic factors in patients with submucosal esophageal cancer. Univariate analysis showed that lymph node metastasis, subdivision of tumor depth, and lymphatic invasion were correlated with prognosis, whereas sex, age, tumor location, surgical procedure, adjuvant therapy, histologic findings, and venous invasion did not affect prognosis. Multivariate analysis demonstrated lymph node metastasis to be the only significant prognostic factor in submucosal esophageal cancer. Although subdivisions of tumor depth did not reach significance as prognostic factors, lymph node metastasis was strongly related to tumor depth. To select the individualized treatment in patients with submucosal esophageal cancer, accurate diagnosis of lymph node metastasis necessitates a combination of imaging methods such as endoscopic ultrasound-guided fine-needle aspiration, computed tomography, and positron emission tomography.

KW - Esophageal cancer

KW - lymph node metastasis

KW - submucosal invasion

UR - http://www.scopus.com/inward/record.url?scp=3042833036&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=3042833036&partnerID=8YFLogxK

U2 - 10.1016/j.gassur.2004.02.004

DO - 10.1016/j.gassur.2004.02.004

M3 - Article

C2 - 15240002

AN - SCOPUS:3042833036

VL - 8

SP - 631

EP - 635

JO - Journal of Gastrointestinal Surgery

JF - Journal of Gastrointestinal Surgery

SN - 1091-255X

IS - 5

ER -