TY - JOUR
T1 - Prognostic factors in patients with submucosal esophageal cancer
AU - Natsugoe, Shoji
AU - Matsumoto, Masataka
AU - Okumura, Hiroshi
AU - Ikeda, Masanori
AU - Ishigami, Sumiya
AU - Owaki, Tetsuhiro
AU - Takao, Sonshin
AU - Aikou, Takashi
PY - 2004/7/1
Y1 - 2004/7/1
N2 - The detection rate of early-stage esophageal cancer has increased recently. Various types of treatment including endoscopic mucosal resection, blunt dissection, and esophagectomy with extended lymphadenectomy are employed in patients with submucosal esophageal cancer. The purpose of the present study was to analyze prognostic factors in patients with submucosal esophageal cancer. Univariate analysis showed that lymph node metastasis, subdivision of tumor depth, and lymphatic invasion were correlated with prognosis, whereas sex, age, tumor location, surgical procedure, adjuvant therapy, histologic findings, and venous invasion did not affect prognosis. Multivariate analysis demonstrated lymph node metastasis to be the only significant prognostic factor in submucosal esophageal cancer. Although subdivisions of tumor depth did not reach significance as prognostic factors, lymph node metastasis was strongly related to tumor depth. To select the individualized treatment in patients with submucosal esophageal cancer, accurate diagnosis of lymph node metastasis necessitates a combination of imaging methods such as endoscopic ultrasound-guided fine-needle aspiration, computed tomography, and positron emission tomography.
AB - The detection rate of early-stage esophageal cancer has increased recently. Various types of treatment including endoscopic mucosal resection, blunt dissection, and esophagectomy with extended lymphadenectomy are employed in patients with submucosal esophageal cancer. The purpose of the present study was to analyze prognostic factors in patients with submucosal esophageal cancer. Univariate analysis showed that lymph node metastasis, subdivision of tumor depth, and lymphatic invasion were correlated with prognosis, whereas sex, age, tumor location, surgical procedure, adjuvant therapy, histologic findings, and venous invasion did not affect prognosis. Multivariate analysis demonstrated lymph node metastasis to be the only significant prognostic factor in submucosal esophageal cancer. Although subdivisions of tumor depth did not reach significance as prognostic factors, lymph node metastasis was strongly related to tumor depth. To select the individualized treatment in patients with submucosal esophageal cancer, accurate diagnosis of lymph node metastasis necessitates a combination of imaging methods such as endoscopic ultrasound-guided fine-needle aspiration, computed tomography, and positron emission tomography.
KW - Esophageal cancer
KW - lymph node metastasis
KW - submucosal invasion
UR - http://www.scopus.com/inward/record.url?scp=3042833036&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=3042833036&partnerID=8YFLogxK
U2 - 10.1016/j.gassur.2004.02.004
DO - 10.1016/j.gassur.2004.02.004
M3 - Article
C2 - 15240002
AN - SCOPUS:3042833036
SN - 1091-255X
VL - 8
SP - 631
EP - 635
JO - Journal of Gastrointestinal Surgery
JF - Journal of Gastrointestinal Surgery
IS - 5
ER -
