Prognostic factors in node-positive patients with stage IB-IIB cervical cancer treated by radical hysterectomy and pelvic lymphadenectomy

J. Kodama, N. Seki, Y. Ojima, Keiichiro Nakamura, A. Hongo, Y. Hiramatsu

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Objective: The purpose of the present study was to identify prognostic factors in surgically treated patients with stage IB-IIB cervical cancers, who also presented with positive pelvic nodes. Method: The patient population consisted of 68 individuals presenting with stage IB-IIB cervical cancers and with histologically proven pelvic lymph nodes. Result: We found no association between the type of adjuvant therapy and patient outcome. Multivariate analysis revealed that non-squamous histology was an independent prognostic factor for disease-free and overall survival rates. In squamous cell carcinomas, the bilateral nature of the positive nodes was found to be a significant factor for disease-free survival rates. In non-squamous cell carcinomas, positive nodes of more than 2 cm in size were found to be a significant factor for disease-free survival rates. Conclusion: Non-squamous histology was an independent prognostic factor and chemoradiotherapy did not improve the survival outcomes of the patients in this study population.

Original languageEnglish
Pages (from-to)130-135
Number of pages6
JournalInternational Journal of Gynecology and Obstetrics
Volume93
Issue number2
DOIs
Publication statusPublished - May 2006

Fingerprint

Lymph Node Excision
Hysterectomy
Uterine Cervical Neoplasms
Disease-Free Survival
Survival Rate
Histology
Chemoradiotherapy
Population
Squamous Cell Carcinoma
Multivariate Analysis
Lymph Nodes
Carcinoma
Survival
Therapeutics

Keywords

  • Cervical cancer
  • Chemoradiotherapy
  • Positive nodes
  • Prognosis

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Prognostic factors in node-positive patients with stage IB-IIB cervical cancer treated by radical hysterectomy and pelvic lymphadenectomy. / Kodama, J.; Seki, N.; Ojima, Y.; Nakamura, Keiichiro; Hongo, A.; Hiramatsu, Y.

In: International Journal of Gynecology and Obstetrics, Vol. 93, No. 2, 05.2006, p. 130-135.

Research output: Contribution to journalArticle

@article{a4d846a2dfef484ca634a9018c93c2fb,
title = "Prognostic factors in node-positive patients with stage IB-IIB cervical cancer treated by radical hysterectomy and pelvic lymphadenectomy",
abstract = "Objective: The purpose of the present study was to identify prognostic factors in surgically treated patients with stage IB-IIB cervical cancers, who also presented with positive pelvic nodes. Method: The patient population consisted of 68 individuals presenting with stage IB-IIB cervical cancers and with histologically proven pelvic lymph nodes. Result: We found no association between the type of adjuvant therapy and patient outcome. Multivariate analysis revealed that non-squamous histology was an independent prognostic factor for disease-free and overall survival rates. In squamous cell carcinomas, the bilateral nature of the positive nodes was found to be a significant factor for disease-free survival rates. In non-squamous cell carcinomas, positive nodes of more than 2 cm in size were found to be a significant factor for disease-free survival rates. Conclusion: Non-squamous histology was an independent prognostic factor and chemoradiotherapy did not improve the survival outcomes of the patients in this study population.",
keywords = "Cervical cancer, Chemoradiotherapy, Positive nodes, Prognosis",
author = "J. Kodama and N. Seki and Y. Ojima and Keiichiro Nakamura and A. Hongo and Y. Hiramatsu",
year = "2006",
month = "5",
doi = "10.1016/j.ijgo.2006.02.012",
language = "English",
volume = "93",
pages = "130--135",
journal = "International Journal of Gynecology and Obstetrics",
issn = "0020-7292",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

TY - JOUR

T1 - Prognostic factors in node-positive patients with stage IB-IIB cervical cancer treated by radical hysterectomy and pelvic lymphadenectomy

AU - Kodama, J.

AU - Seki, N.

AU - Ojima, Y.

AU - Nakamura, Keiichiro

AU - Hongo, A.

AU - Hiramatsu, Y.

PY - 2006/5

Y1 - 2006/5

N2 - Objective: The purpose of the present study was to identify prognostic factors in surgically treated patients with stage IB-IIB cervical cancers, who also presented with positive pelvic nodes. Method: The patient population consisted of 68 individuals presenting with stage IB-IIB cervical cancers and with histologically proven pelvic lymph nodes. Result: We found no association between the type of adjuvant therapy and patient outcome. Multivariate analysis revealed that non-squamous histology was an independent prognostic factor for disease-free and overall survival rates. In squamous cell carcinomas, the bilateral nature of the positive nodes was found to be a significant factor for disease-free survival rates. In non-squamous cell carcinomas, positive nodes of more than 2 cm in size were found to be a significant factor for disease-free survival rates. Conclusion: Non-squamous histology was an independent prognostic factor and chemoradiotherapy did not improve the survival outcomes of the patients in this study population.

AB - Objective: The purpose of the present study was to identify prognostic factors in surgically treated patients with stage IB-IIB cervical cancers, who also presented with positive pelvic nodes. Method: The patient population consisted of 68 individuals presenting with stage IB-IIB cervical cancers and with histologically proven pelvic lymph nodes. Result: We found no association between the type of adjuvant therapy and patient outcome. Multivariate analysis revealed that non-squamous histology was an independent prognostic factor for disease-free and overall survival rates. In squamous cell carcinomas, the bilateral nature of the positive nodes was found to be a significant factor for disease-free survival rates. In non-squamous cell carcinomas, positive nodes of more than 2 cm in size were found to be a significant factor for disease-free survival rates. Conclusion: Non-squamous histology was an independent prognostic factor and chemoradiotherapy did not improve the survival outcomes of the patients in this study population.

KW - Cervical cancer

KW - Chemoradiotherapy

KW - Positive nodes

KW - Prognosis

UR - http://www.scopus.com/inward/record.url?scp=33646049711&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33646049711&partnerID=8YFLogxK

U2 - 10.1016/j.ijgo.2006.02.012

DO - 10.1016/j.ijgo.2006.02.012

M3 - Article

C2 - 16563395

AN - SCOPUS:33646049711

VL - 93

SP - 130

EP - 135

JO - International Journal of Gynecology and Obstetrics

JF - International Journal of Gynecology and Obstetrics

SN - 0020-7292

IS - 2

ER -