Abstract
Background: Recently, reports of influenza-associated encephalopathy have increased worldwide. Given the high mortality and morbidity rates attributable to this severe neurologic complication of influenza, we conducted a nationwide study in Japan to identify the prognostic factors. Methods: We retrospectively evaluated 442 cases of influenza-associated encephalopathy that were reported to the Collaborative Study Group on Influenza-Associated Encephalopathy, which was organized by the Japanese Ministry of Health, Labor, and Welfare in collaboration with hospitals, clinics, and local pediatric practices in Japan between 1998 and 2002. The outcome for each patient was classified as either survival or death. Predictors of death were identified using logistic regression analysis. Results: Four major prognostic factors for death were found to be significant by multivariate analysis (P <0.05) in the 184 patients for whom we had complete data: elevation of aspartate aminotransferase, hyperglycemia, the presence of hematuria or proteinuria, and use of diclofenac sodium. Conclusions: We identified patients who had factors associated with a poor prognosis, and these findings might be clinically useful for the management of this illness.
| Original language | English |
|---|---|
| Pages (from-to) | 384-389 |
| Number of pages | 6 |
| Journal | Pediatric Infectious Disease Journal |
| Volume | 27 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - May 2008 |
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Keywords
- diclofenac
- hypercytokinemia
- IL-6
- nfluenza-associated encephalopathy
- TNF-α
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Infectious Diseases
- Microbiology (medical)
Cite this
Prognostic factors in influenza-associated encephalopathy. / Nagao, Takashi; Morishima, Tsuneo; Kimura, Hiroshi; Yokota, Syumpei; Yamashita, Nobuko; Ichiyama, Takashi; Kurihara, Mana; Miyazaki, Chiaki; Okabe, Nobuhiko.
In: Pediatric Infectious Disease Journal, Vol. 27, No. 5, 05.2008, p. 384-389.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Prognostic factors in influenza-associated encephalopathy
AU - Nagao, Takashi
AU - Morishima, Tsuneo
AU - Kimura, Hiroshi
AU - Yokota, Syumpei
AU - Yamashita, Nobuko
AU - Ichiyama, Takashi
AU - Kurihara, Mana
AU - Miyazaki, Chiaki
AU - Okabe, Nobuhiko
PY - 2008/5
Y1 - 2008/5
N2 - Background: Recently, reports of influenza-associated encephalopathy have increased worldwide. Given the high mortality and morbidity rates attributable to this severe neurologic complication of influenza, we conducted a nationwide study in Japan to identify the prognostic factors. Methods: We retrospectively evaluated 442 cases of influenza-associated encephalopathy that were reported to the Collaborative Study Group on Influenza-Associated Encephalopathy, which was organized by the Japanese Ministry of Health, Labor, and Welfare in collaboration with hospitals, clinics, and local pediatric practices in Japan between 1998 and 2002. The outcome for each patient was classified as either survival or death. Predictors of death were identified using logistic regression analysis. Results: Four major prognostic factors for death were found to be significant by multivariate analysis (P <0.05) in the 184 patients for whom we had complete data: elevation of aspartate aminotransferase, hyperglycemia, the presence of hematuria or proteinuria, and use of diclofenac sodium. Conclusions: We identified patients who had factors associated with a poor prognosis, and these findings might be clinically useful for the management of this illness.
AB - Background: Recently, reports of influenza-associated encephalopathy have increased worldwide. Given the high mortality and morbidity rates attributable to this severe neurologic complication of influenza, we conducted a nationwide study in Japan to identify the prognostic factors. Methods: We retrospectively evaluated 442 cases of influenza-associated encephalopathy that were reported to the Collaborative Study Group on Influenza-Associated Encephalopathy, which was organized by the Japanese Ministry of Health, Labor, and Welfare in collaboration with hospitals, clinics, and local pediatric practices in Japan between 1998 and 2002. The outcome for each patient was classified as either survival or death. Predictors of death were identified using logistic regression analysis. Results: Four major prognostic factors for death were found to be significant by multivariate analysis (P <0.05) in the 184 patients for whom we had complete data: elevation of aspartate aminotransferase, hyperglycemia, the presence of hematuria or proteinuria, and use of diclofenac sodium. Conclusions: We identified patients who had factors associated with a poor prognosis, and these findings might be clinically useful for the management of this illness.
KW - diclofenac
KW - hypercytokinemia
KW - IL-6
KW - nfluenza-associated encephalopathy
KW - TNF-α
UR - http://www.scopus.com/inward/record.url?scp=45849097283&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=45849097283&partnerID=8YFLogxK
U2 - 10.1097/INF.0b013e318162a13b
DO - 10.1097/INF.0b013e318162a13b
M3 - Article
C2 - 18398388
AN - SCOPUS:45849097283
VL - 27
SP - 384
EP - 389
JO - Pediatric Infectious Disease Journal
JF - Pediatric Infectious Disease Journal
SN - 0891-3668
IS - 5
ER -