Abstract
In an attempt to determine the prognostic significance of pretreatment factors for patients with advanced non-small cell lung cancer (NSCLC), 24 pretreatment clinical variables were analyzed for 185 patients with NSCLC who underwent chemotherapy and/or radiotherapy between 1985 and 1994. Following univariate analysis, we applied two multivariate statistical techniques. In a Cox regression model, independently significant factors influencing patient survival included performance status (PS), disease stage, hemoglobin level, and serum calcium level. Recursive partitioning and amalgamation (RPA) resulted in three distinct prognostic subgroups based on PS, stage, weight loss, and hemoglobin level. The best survival was observed for patients with a good PS and Stage III disease who had a hemoglobin level > 11 g/dl. The worst survival was observed for patients with a poor PS and presence of weight loss irrespective of stage. All other patients had an intermediate prognosis. Median survival times were 95.1 weeks, 17.1 weeks and 39.3 weeks, respectively (P <0.00005). The results of our analyses show that three important prognostic subgroups could readily be discerned using RPA.
| Original language | English |
|---|---|
| Pages (from-to) | 67-77 |
| Number of pages | 11 |
| Journal | Lung Cancer |
| Volume | 15 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Aug 1996 |
| Externally published | Yes |
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Keywords
- Chemotherapy
- Non-small cell lung cancer
- Prognostic factor
- Radiotherapy
- Recursive partitioning and amalgamation
ASJC Scopus subject areas
- Oncology
Cite this
Prognostic factors for patients with advanced non-small cell lung cancer : Univariate and multivariate analyses including recursive partitioning and amalgamation. / Takigawa, Nagio; Segawa, Yoshihiko; Okahara, Masayuki; Maeda, Yoshinobu; Takata, Ichiro; Kataoka, Masaaki; Fujii, Masafumi.
In: Lung Cancer, Vol. 15, No. 1, 08.1996, p. 67-77.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Prognostic factors for patients with advanced non-small cell lung cancer
T2 - Univariate and multivariate analyses including recursive partitioning and amalgamation
AU - Takigawa, Nagio
AU - Segawa, Yoshihiko
AU - Okahara, Masayuki
AU - Maeda, Yoshinobu
AU - Takata, Ichiro
AU - Kataoka, Masaaki
AU - Fujii, Masafumi
PY - 1996/8
Y1 - 1996/8
N2 - In an attempt to determine the prognostic significance of pretreatment factors for patients with advanced non-small cell lung cancer (NSCLC), 24 pretreatment clinical variables were analyzed for 185 patients with NSCLC who underwent chemotherapy and/or radiotherapy between 1985 and 1994. Following univariate analysis, we applied two multivariate statistical techniques. In a Cox regression model, independently significant factors influencing patient survival included performance status (PS), disease stage, hemoglobin level, and serum calcium level. Recursive partitioning and amalgamation (RPA) resulted in three distinct prognostic subgroups based on PS, stage, weight loss, and hemoglobin level. The best survival was observed for patients with a good PS and Stage III disease who had a hemoglobin level > 11 g/dl. The worst survival was observed for patients with a poor PS and presence of weight loss irrespective of stage. All other patients had an intermediate prognosis. Median survival times were 95.1 weeks, 17.1 weeks and 39.3 weeks, respectively (P <0.00005). The results of our analyses show that three important prognostic subgroups could readily be discerned using RPA.
AB - In an attempt to determine the prognostic significance of pretreatment factors for patients with advanced non-small cell lung cancer (NSCLC), 24 pretreatment clinical variables were analyzed for 185 patients with NSCLC who underwent chemotherapy and/or radiotherapy between 1985 and 1994. Following univariate analysis, we applied two multivariate statistical techniques. In a Cox regression model, independently significant factors influencing patient survival included performance status (PS), disease stage, hemoglobin level, and serum calcium level. Recursive partitioning and amalgamation (RPA) resulted in three distinct prognostic subgroups based on PS, stage, weight loss, and hemoglobin level. The best survival was observed for patients with a good PS and Stage III disease who had a hemoglobin level > 11 g/dl. The worst survival was observed for patients with a poor PS and presence of weight loss irrespective of stage. All other patients had an intermediate prognosis. Median survival times were 95.1 weeks, 17.1 weeks and 39.3 weeks, respectively (P <0.00005). The results of our analyses show that three important prognostic subgroups could readily be discerned using RPA.
KW - Chemotherapy
KW - Non-small cell lung cancer
KW - Prognostic factor
KW - Radiotherapy
KW - Recursive partitioning and amalgamation
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UR - http://www.scopus.com/inward/citedby.url?scp=0030220305&partnerID=8YFLogxK
U2 - 10.1016/0169-5002(96)00571-5
DO - 10.1016/0169-5002(96)00571-5
M3 - Article
C2 - 8865124
AN - SCOPUS:0030220305
VL - 15
SP - 67
EP - 77
JO - Lung Cancer
JF - Lung Cancer
SN - 0169-5002
IS - 1
ER -