Prognostic analysis and a new risk model for Hodgkin lymphoma in Japan

Kuniaki Itoh, Tomohiro Kinoshita, Takashi Watanabe, Kenichi Yoshimura, Rumiko Okamoto, Takaaki Chou, Michinori Ogura, Masami Hirano, Hideki Asaoku, Mitsutoshi Kurosawa, Yoshiharu Maeda, Ken Omachi, Yukiyoshi Moriuchi, Masaharu Kasai, Kazunori Ohnishi, Nobuyuki Takayama, Yasuo Morishima, Kensei Tobinai, Harumi Kaba, Seiichiro YamamotoHaruhiko Fukuda, Masahiro Kikuchi, Tadashi Yoshino, Yoshihiro Matsuno, Tomomitsu Hotta, Masanori Shimoyama

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The Japan Clinical Oncology Group conducted two multicenter phase II trials in 200 patients with advanced Hodgkin lymphoma (HL) in the 1990s. Among 181 patients whose histopathological specimens were available and reviewed by 6 hematopathologists, 167 (92.3%) were diagnosed with HL. Five-year overall survival (OS) among these 167 patients was 88.3%, including 89.2% among nodular sclerosis and 82.2% among mixed cellularity cases. International prognostic score was not closely associated with OS. Seven unfavorable prognostic factors for OS on univariate analysis were male, B symptoms, clinical stage of III or IV, elevated serum LDH, elevated alkaline phosphatase, elevated β2-microglobulin, and pathological subtype (mixed cellularity and lymphocyte depletion). On multivariate analysis, male [HR 3.30 (95% CI 1.15-9.52, p = 0.027)] and elevated serum LDH [HR 2.41 (95% CI 1.07-5.43, p = 0.034)] were independent factors for OS. Based on these prognostic factors, the 5-year OS was 95.7% in the low-risk group (no adverse factor), 87.9% in the intermediate-risk group (1 adverse factor) and 73.3% in the high-risk group (2 adverse factors). This simple prognostic model for HL warrants further validation studies.

Original languageEnglish
Pages (from-to)446-455
Number of pages10
JournalInternational journal of hematology
Volume91
Issue number3
DOIs
Publication statusPublished - Apr 2010

Keywords

  • International prognostic score
  • LDH
  • Male gender
  • Multicenter phase II trial
  • Overall survival
  • Prognostic factor

ASJC Scopus subject areas

  • Hematology

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    Itoh, K., Kinoshita, T., Watanabe, T., Yoshimura, K., Okamoto, R., Chou, T., Ogura, M., Hirano, M., Asaoku, H., Kurosawa, M., Maeda, Y., Omachi, K., Moriuchi, Y., Kasai, M., Ohnishi, K., Takayama, N., Morishima, Y., Tobinai, K., Kaba, H., ... Shimoyama, M. (2010). Prognostic analysis and a new risk model for Hodgkin lymphoma in Japan. International journal of hematology, 91(3), 446-455. https://doi.org/10.1007/s12185-010-0533-9