Prognosis of smokers following resection of pathological stage I non-small-cell lung carcinoma

Noriyoshi Sawabata, Shinichiro Miyoshi, Akihide Matsumura, Mitsunori Ohta, Hajime Maeda, Hirofumi Sueki, Masanobu Hayakawa, Meinoshin Okumura, Yoshiki Sawa

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14 Citations (Scopus)

Abstract

Objective. Many patients who undergo surgery for non-small-cell lung cancer (NSCLC) have a smoking habit, which is a risk factor for NSCLC and chronic obstructive pulmonary disease (COPD). In addition, both smoking habits and COPD has been revealed to be a prognostic indicator following surgery for NSCLC. We conducted a multicenter retrospective observational study to address these issues. Methods. Cigarette smoking and airway obstruction severity were chosen as variables to assess overall and disease-specific survival of 169 patients with pathological stage I primary NSCLC (119 stage IA, 50 stage IB) who underwent resection in 2000. Results. The overall 5-year survival rates were 91% for patients who had never smoked (n = 66), 88% for ex-smokers (n = 36), and 72% for current smokers (n = 67) (P = 0.04). The never-smoked group had higher ratios for the factors female, pathological IA, adenocarcinoma, and favorable airway obstruction. In a nested analysis of smokers (ex-smokers and current smokers), smoking status and age were independent factors in a multivariate analysis of disease-specific survival, whereas the degree of airway obstruction was not significant. Conclusion. For smokers who underwent resection of p-stage I NSCLC, current smoking was an unfavorable prognostic factor in an analysis containing the degree of airway obstruction as a variable.

Original languageEnglish
Pages (from-to)420-424
Number of pages5
JournalGeneral Thoracic and Cardiovascular Surgery
Volume55
Issue number10
DOIs
Publication statusPublished - Oct 1 2007

Keywords

  • COPD
  • Non-small cell lung cancer
  • Smoking
  • Stage I

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

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    Sawabata, N., Miyoshi, S., Matsumura, A., Ohta, M., Maeda, H., Sueki, H., Hayakawa, M., Okumura, M., & Sawa, Y. (2007). Prognosis of smokers following resection of pathological stage I non-small-cell lung carcinoma. General Thoracic and Cardiovascular Surgery, 55(10), 420-424. https://doi.org/10.1007/s11748-007-0159-x