Prognosis of patients with bladder tumors who received intra-arterial infusion chemotherapy in combination with angiotensin II

M. Saegusa, K. Kobashi, J. Ochi, M. Hara, T. Obama, J. Yoshimoto, Y. Matsumura, H. Ohmori, T. Johsen, Y. Nasu, T. Hayashi, T. Akaeda, A. Nagai, T. Akagi

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Abstract

A combination of 70 mg/m2. cis-platinum, 40 mg/m2. doxorubicin or 40 mg/m2 tetrahydropyranyldoxorubicin instead of doxorubicin, and angiotensin II was infused into the bilateral internal iliac artery for the treatment of 31 patients with advanced bladder cancer (T2~T4). Of the 31 patients, 9 achieved CR and 16 achieved PR. We researched the prognosis of the patients, and discuss the usefulness of intra-arterial infusion chemotherapy (Al). Of 5 who achieved CR and underwent no successive therapy, 4 had recurrence and 2 died from cancer. This means Al is not sufficient by itself. Of 9 who achieved CR or PR and who finally underwent total cystectomy, 6 are disease free now. Therefore, we may expect Al to be useful as an adjuvant therapy prior to total cystectomy. The problems with this study were the follow-up duration and the number of patients. After we have continued to follow up patients for over 5 years, have increased the number of patients, and have compared the results with those cases who received no Al, a final conclusion should be considered.

Original languageEnglish
Pages (from-to)578-582
Number of pages5
JournalNishinihon Journal of Urology
Volume52
Issue number5
Publication statusPublished - Jan 1 1990

ASJC Scopus subject areas

  • Urology

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    Saegusa, M., Kobashi, K., Ochi, J., Hara, M., Obama, T., Yoshimoto, J., Matsumura, Y., Ohmori, H., Johsen, T., Nasu, Y., Hayashi, T., Akaeda, T., Nagai, A., & Akagi, T. (1990). Prognosis of patients with bladder tumors who received intra-arterial infusion chemotherapy in combination with angiotensin II. Nishinihon Journal of Urology, 52(5), 578-582.