Abstract
Using autologous normal skin and freshly separated sera, the titers of circulating anti-stratum corneum (SC) IgG autoantibodies, which were predominantly demonstrated by ordinary indirectimmuno-fluorescence (IF), and those of complement-fixing anti-SC autoanibodies were compared in 16 proriatic patients with active lesions, 16 patients with nonpsoriatic inflammatory dermatoses, and 11 normal subjects. As in patients with other inflammaroty dermatoses, the titers of IgG anti-SC autoantibodies in psoriatic patients were not specifically higher than in normal controls but were more variable, indicating that their circulating levels are dependent on a delicate balance between consumption at inflammatory sites and a secondary increase due to SC-antigen release following inflammation. The titers of complement-fixing anti-SC autoantibodies were much higher than those of IgG autoantibodies in most cases but they were not particularly high in psoriatic patients. From these findings, we think that if these autoantibodies are really involved in complement activation in inducing the transepidermal leukocyte migration of psoriatic lesions, a local factor of psoriatic epidermis, which may facilitate the permeation of these antibodies toward the SC, plays a more important role than the actual circulating antibody levels.
| Original language | English |
|---|---|
| Pages (from-to) | 71-75 |
| Number of pages | 5 |
| Journal | Archives of Dermatological Research |
| Volume | 275 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Apr 1983 |
| Externally published | Yes |
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Keywords
- Anti-stratum corneum autoantibodies
- Immunofluorescence studies
- Psoriasis
ASJC Scopus subject areas
- Dermatology
Cite this
Profile of anti-stratum corneum autoantibodies in psoriatic patients. / Tagami, Hachiro; Iwatsuki, Keiji; Yamada, Mizuho.
In: Archives of Dermatological Research, Vol. 275, No. 2, 04.1983, p. 71-75.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Profile of anti-stratum corneum autoantibodies in psoriatic patients
AU - Tagami, Hachiro
AU - Iwatsuki, Keiji
AU - Yamada, Mizuho
PY - 1983/4
Y1 - 1983/4
N2 - Using autologous normal skin and freshly separated sera, the titers of circulating anti-stratum corneum (SC) IgG autoantibodies, which were predominantly demonstrated by ordinary indirectimmuno-fluorescence (IF), and those of complement-fixing anti-SC autoanibodies were compared in 16 proriatic patients with active lesions, 16 patients with nonpsoriatic inflammatory dermatoses, and 11 normal subjects. As in patients with other inflammaroty dermatoses, the titers of IgG anti-SC autoantibodies in psoriatic patients were not specifically higher than in normal controls but were more variable, indicating that their circulating levels are dependent on a delicate balance between consumption at inflammatory sites and a secondary increase due to SC-antigen release following inflammation. The titers of complement-fixing anti-SC autoantibodies were much higher than those of IgG autoantibodies in most cases but they were not particularly high in psoriatic patients. From these findings, we think that if these autoantibodies are really involved in complement activation in inducing the transepidermal leukocyte migration of psoriatic lesions, a local factor of psoriatic epidermis, which may facilitate the permeation of these antibodies toward the SC, plays a more important role than the actual circulating antibody levels.
AB - Using autologous normal skin and freshly separated sera, the titers of circulating anti-stratum corneum (SC) IgG autoantibodies, which were predominantly demonstrated by ordinary indirectimmuno-fluorescence (IF), and those of complement-fixing anti-SC autoanibodies were compared in 16 proriatic patients with active lesions, 16 patients with nonpsoriatic inflammatory dermatoses, and 11 normal subjects. As in patients with other inflammaroty dermatoses, the titers of IgG anti-SC autoantibodies in psoriatic patients were not specifically higher than in normal controls but were more variable, indicating that their circulating levels are dependent on a delicate balance between consumption at inflammatory sites and a secondary increase due to SC-antigen release following inflammation. The titers of complement-fixing anti-SC autoantibodies were much higher than those of IgG autoantibodies in most cases but they were not particularly high in psoriatic patients. From these findings, we think that if these autoantibodies are really involved in complement activation in inducing the transepidermal leukocyte migration of psoriatic lesions, a local factor of psoriatic epidermis, which may facilitate the permeation of these antibodies toward the SC, plays a more important role than the actual circulating antibody levels.
KW - Anti-stratum corneum autoantibodies
KW - Immunofluorescence studies
KW - Psoriasis
UR - http://www.scopus.com/inward/record.url?scp=0020583548&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0020583548&partnerID=8YFLogxK
U2 - 10.1007/BF00412877
DO - 10.1007/BF00412877
M3 - Article
C2 - 6870346
AN - SCOPUS:0020583548
VL - 275
SP - 71
EP - 75
JO - Archives of Dermatological Research
JF - Archives of Dermatological Research
SN - 0340-3696
IS - 2
ER -