Profile of anti-stratum corneum autoantibodies in psoriatic patients

Hachiro Tagami, Keiji Iwatsuki, Mizuho Yamada

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


Using autologous normal skin and freshly separated sera, the titers of circulating anti-stratum corneum (SC) IgG autoantibodies, which were predominantly demonstrated by ordinary indirectimmuno-fluorescence (IF), and those of complement-fixing anti-SC autoanibodies were compared in 16 proriatic patients with active lesions, 16 patients with nonpsoriatic inflammatory dermatoses, and 11 normal subjects. As in patients with other inflammaroty dermatoses, the titers of IgG anti-SC autoantibodies in psoriatic patients were not specifically higher than in normal controls but were more variable, indicating that their circulating levels are dependent on a delicate balance between consumption at inflammatory sites and a secondary increase due to SC-antigen release following inflammation. The titers of complement-fixing anti-SC autoantibodies were much higher than those of IgG autoantibodies in most cases but they were not particularly high in psoriatic patients. From these findings, we think that if these autoantibodies are really involved in complement activation in inducing the transepidermal leukocyte migration of psoriatic lesions, a local factor of psoriatic epidermis, which may facilitate the permeation of these antibodies toward the SC, plays a more important role than the actual circulating antibody levels.

Original languageEnglish
Pages (from-to)71-75
Number of pages5
JournalArchives of Dermatological Research
Issue number2
Publication statusPublished - Apr 1983


  • Anti-stratum corneum autoantibodies
  • Immunofluorescence studies
  • Psoriasis

ASJC Scopus subject areas

  • Dermatology


Dive into the research topics of 'Profile of anti-stratum corneum autoantibodies in psoriatic patients'. Together they form a unique fingerprint.

Cite this