Product selectivity of esterification of L-aspartic acid and L-glutamic acid using chlorotrimethylsilane

Tomohiro Takaishi, Minoru Izumi, Ryo Ota, Chieri Inoue, Hiromasa Kiyota, Koichi Fukase

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

TMSCl works as an acid catalyst precursor for selective esterification of L-aspartic and L-glutamic acids in the presence of primary, secondary and tertiary alcohols. Although excess TMSCl was required for the completion of esterification, the resulting alkyl TMS ether could be azeotropically removed by simple evaporation with alcohol.

Original languageEnglish
Pages (from-to)247-249
Number of pages3
JournalNatural Product Communications
Volume12
Issue number2
Publication statusPublished - 2017

Fingerprint

Esterification
esterification
aspartic acid
glutamic acid
Aspartic Acid
Glutamic Acid
alcohols
Alcohols
catalysts
Ether
evaporation
ethers
Acids
acids
trimethylchlorosilane

Keywords

  • Acid catalyst
  • Aspartic acid
  • Esterification
  • Protective group
  • TMSCl

ASJC Scopus subject areas

  • Medicine(all)
  • Pharmacology
  • Plant Science
  • Drug Discovery
  • Complementary and alternative medicine

Cite this

Product selectivity of esterification of L-aspartic acid and L-glutamic acid using chlorotrimethylsilane. / Takaishi, Tomohiro; Izumi, Minoru; Ota, Ryo; Inoue, Chieri; Kiyota, Hiromasa; Fukase, Koichi.

In: Natural Product Communications, Vol. 12, No. 2, 2017, p. 247-249.

Research output: Contribution to journalArticle

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AU - Fukase, Koichi

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