Product selectivity of esterification of L-aspartic acid and L-glutamic acid using chlorotrimethylsilane

Tomohiro Takaishi, Minoru Izumi, Ryo Ota, Chieri Inoue, Hiromasa Kiyota, Koichi Fukase

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

TMSCl works as an acid catalyst precursor for selective esterification of L-aspartic and L-glutamic acids in the presence of primary, secondary and tertiary alcohols. Although excess TMSCl was required for the completion of esterification, the resulting alkyl TMS ether could be azeotropically removed by simple evaporation with alcohol.

Original languageEnglish
Pages (from-to)247-249
Number of pages3
JournalNatural product communications
Volume12
Issue number2
DOIs
Publication statusPublished - Jan 1 2017

Keywords

  • Acid catalyst
  • Aspartic acid
  • Esterification
  • Protective group
  • TMSCl

ASJC Scopus subject areas

  • Pharmacology
  • Plant Science
  • Drug Discovery
  • Complementary and alternative medicine

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