Product selectivity of esterification of L-aspartic acid and L-glutamic acid using chlorotrimethylsilane

Tomohiro Takaishi; Minoru Izumi; Ryo Ota; Chieri Inoue; Hiromasa Kiyota; Koichi Fukase

doi:10.1177/1934578x1701200227

Product selectivity of esterification of L-aspartic acid and L-glutamic acid using chlorotrimethylsilane

Tomohiro Takaishi, Minoru Izumi, Ryo Ota, Chieri Inoue, Hiromasa Kiyota, Koichi Fukase

Research output: Contribution to journal › Article

1 Citation (Scopus)

Abstract

TMSCl works as an acid catalyst precursor for selective esterification of L-aspartic and L-glutamic acids in the presence of primary, secondary and tertiary alcohols. Although excess TMSCl was required for the completion of esterification, the resulting alkyl TMS ether could be azeotropically removed by simple evaporation with alcohol.

Original language	English
Pages (from-to)	247-249
Number of pages	3
Journal	Natural product communications
Volume	12
Issue number	2
DOIs	https://doi.org/10.1177/1934578x1701200227
Publication status	Published - Jan 1 2017

Keywords

Acid catalyst
Aspartic acid
Esterification
Protective group
TMSCl

ASJC Scopus subject areas

Pharmacology
Plant Science
Drug Discovery
Complementary and alternative medicine

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abstract = "TMSCl works as an acid catalyst precursor for selective esterification of L-aspartic and L-glutamic acids in the presence of primary, secondary and tertiary alcohols. Although excess TMSCl was required for the completion of esterification, the resulting alkyl TMS ether could be azeotropically removed by simple evaporation with alcohol.",

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T1 - Product selectivity of esterification of L-aspartic acid and L-glutamic acid using chlorotrimethylsilane

AU - Takaishi, Tomohiro

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AU - Ota, Ryo

AU - Inoue, Chieri

AU - Kiyota, Hiromasa

AU - Fukase, Koichi

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N2 - TMSCl works as an acid catalyst precursor for selective esterification of L-aspartic and L-glutamic acids in the presence of primary, secondary and tertiary alcohols. Although excess TMSCl was required for the completion of esterification, the resulting alkyl TMS ether could be azeotropically removed by simple evaporation with alcohol.

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KW - Aspartic acid

KW - Esterification

KW - Protective group

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