Processing and activation of recombinant mouse mastocytoma histidine decarboxylase in the particulate fraction of Sf9 cells by porcine pancreatic elastase

Satoshi Tanaka, Tetsuya Fukui, Jun Yamamoto, Yoh ichiro Shima, Toshiaki Kume, Makoto Ohgo, Atsushi Ichikawa

Research output: Contribution to journalArticle

22 Citations (Scopus)


Mature 53 kDa histidine decarboxylase (HDC) peptide is produced from a precursor 74 kDa peptide. The mechanism of specific cleavage by processing enzyme is unknown. Using the recombinant mouse 74 kDa HDC, we found that porcine pancreatic elastase specifically converted the inactive 74 kDa HDC to its active form of 53 kDa HDC.

Original languageEnglish
Pages (from-to)9-12
Number of pages4
JournalBiochimica et Biophysica Acta (BBA)/Protein Structure and Molecular
Issue number1
Publication statusPublished - Nov 15 1995
Externally publishedYes



  • (Mouse)
  • (Porcine)
  • Histidine decarboxylase
  • Mastocytoma
  • Pancreatic elastase
  • Sf9 cell

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology
  • Structural Biology

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