Procedures for prevention of perinatal group B streptococcal diseases: A multicenter questionnaire survey of hospitals in the Kyoto Neonatal Disease Study Group, Japan

Kousaku Matsubara, Masahiko Kawai, Tatsutoshi Nakahata, Fumihide Kato, Hirokazu Tsukahara, Masaru Yamakawa, Kazuhiro Hashimoto, Seiichi Shimada, Shinji Maeda, Mitsuyoshi Okumura, Hiroo Kanaoka

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

To explore clinical protocols for the prevention of early-onset group B Streptococcus (EOGBS) disease of the newborn in Japan, we conducted a multicenter questionnaire survey. Of 32 regional centers participating in the Kyoto Neonatal Study Group, 28 provided usable data concerning prevention practices undertaken between 2000 and 2004. Twenty-three (82%) of the 28 hospitals implemented bacteriological screening to identify maternal GBS carriage, and all 23 hospitals administered intrapartum antibiotics to all screening-positive pregnant women. There were no institutes that used risk-based strategies. In the 23 hospitals, bacteriological screening was conducted mostly by lower vaginal swab alone (n = 18). Eighteen hospitals performed screening once during pregnancy, either before 34 weeks' gestation (n = 6) or between 35 and 37 weeks' gestation (n = 12). Oral antepartum antibiotics, when carriage was identified, were administered at 12 (52%) hospitals. Twenty institutes used penicillins for intrapartum prophylaxis. However, the loading dose for chemoprophylaxis ranged from 0.5 to 2g, and the interval between repeat administrations ranged from 4 to 12h. Although the results indicated that more than 80% of the hospitals surveyed had introduced some screening-based prevention practices, the timing of the bacteriological screening during the pregnancy, the number of screenings, and the screening sites, as well as the antibiotics used, and their dosage, varied widely. Because of these highly variable methods, the efficacy of the implementation of preventive practices could not be determined. This study is the first to have described preventive practices for EOGBS disease in Japan in the era of Centers for Disease Control and Prevention guidelines. In light of the above results, a larger study under a unifying protocol would be warranted.

Original languageEnglish
Pages (from-to)59-62
Number of pages4
JournalJournal of Infection and Chemotherapy
Volume13
Issue number1
DOIs
Publication statusPublished - Feb 2007
Externally publishedYes

Fingerprint

Infant, Newborn, Diseases
Japan
Pregnancy
Streptococcus agalactiae
Anti-Bacterial Agents
Chemoprevention
Centers for Disease Control and Prevention (U.S.)
Clinical Protocols
Penicillins
Surveys and Questionnaires
Pregnant Women
Mothers
Newborn Infant
Guidelines

Keywords

  • Group B Streptococcus
  • Guideline
  • Neonatal infection
  • Prophylaxis
  • Questionnaire
  • Screening test

ASJC Scopus subject areas

  • Microbiology (medical)

Cite this

Procedures for prevention of perinatal group B streptococcal diseases : A multicenter questionnaire survey of hospitals in the Kyoto Neonatal Disease Study Group, Japan. / Matsubara, Kousaku; Kawai, Masahiko; Nakahata, Tatsutoshi; Kato, Fumihide; Tsukahara, Hirokazu; Yamakawa, Masaru; Hashimoto, Kazuhiro; Shimada, Seiichi; Maeda, Shinji; Okumura, Mitsuyoshi; Kanaoka, Hiroo.

In: Journal of Infection and Chemotherapy, Vol. 13, No. 1, 02.2007, p. 59-62.

Research output: Contribution to journalArticle

Matsubara, Kousaku ; Kawai, Masahiko ; Nakahata, Tatsutoshi ; Kato, Fumihide ; Tsukahara, Hirokazu ; Yamakawa, Masaru ; Hashimoto, Kazuhiro ; Shimada, Seiichi ; Maeda, Shinji ; Okumura, Mitsuyoshi ; Kanaoka, Hiroo. / Procedures for prevention of perinatal group B streptococcal diseases : A multicenter questionnaire survey of hospitals in the Kyoto Neonatal Disease Study Group, Japan. In: Journal of Infection and Chemotherapy. 2007 ; Vol. 13, No. 1. pp. 59-62.
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