Problems of reproductive function in survivors of childhood- and adolescent and young adult-onset cancer revealed in a part of a national survey of Japan

Tatsuro Furui, Yasushi Takai, Fuminori Kimura, Michio Kitajima, Mikiya Nakatsuka, Ken ichiro Morishige, Akiko Higuchi, Chikako Shimizu, Miwa Ozawa, Akira Ohara, Ryohei Tatara, Terukazu Nakamura, Keizo Horibe, Nao Suzuki

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Purpose: This study aimed to evaluate the current status of reproductive disorders as long-term complications in adolescent and young adult (AYA) cancer patients by comparing survivors of childhood-onset with those of AYA-onset cancer in Japan. Methods: We conducted a national survey of AYA cancer survivors and healthy AYAs and analyzed the results from survivors who underwent chemotherapy and reported fertility problems as their current concern. Results: Among all of the childhood-onset survivors, 27 (35.5%; nine males [28.1%] and 18 females [40.9%]) listed reproduction fertility problems as their current concern. Among all AYA-onset survivors, 25 (69.5%; 1/4 males [25.0%] and 24/32 females [75.0%]) listed these problems as a current concern. In contrast, 96.3% (26/27) of all childhood-onset cancer survivors and 68.0% (17/25) of all AYA-onset cancer survivors who received chemotherapy listed these problems as a current concern. Conclusions: A considerable number of both childhood-onset and AYA-onset cancer survivors, and especially those who had undergone chemotherapy, reported reproductive dysfunction as a delayed complication. It is vitally important to establish a supportive care system both for the patients whose fertility was abolished after the completion of cancer treatment and prophylactically for patients before they begin treatment.

Original languageEnglish
Pages (from-to)105-110
Number of pages6
JournalReproductive Medicine and Biology
Volume18
Issue number1
DOIs
Publication statusPublished - Jan 2019

Keywords

  • adolescent
  • cancer survivors
  • fertility preservation
  • reproduction
  • young adults

ASJC Scopus subject areas

  • Reproductive Medicine
  • Cell Biology

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    Furui, T., Takai, Y., Kimura, F., Kitajima, M., Nakatsuka, M., Morishige, K. I., Higuchi, A., Shimizu, C., Ozawa, M., Ohara, A., Tatara, R., Nakamura, T., Horibe, K., & Suzuki, N. (2019). Problems of reproductive function in survivors of childhood- and adolescent and young adult-onset cancer revealed in a part of a national survey of Japan. Reproductive Medicine and Biology, 18(1), 105-110. https://doi.org/10.1002/rmb2.12255