Primitive neuroectodermal tumor with peritoneal metastasis through a ventriculoperitoneal shunt: Case report

Y. Yamamoto, K. Kunishio, M. Suga, N. Sunami, Yuji Yamamoto, H. Sonobe

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

A 13-month-old boy admitted with lethargy and hydrocephalus was found to have a right thalamic mass. Ventricular drainage was instituted, and the tumor mass was reduced by partial resection and local irradiation. A ventriculoperitoneal shunt was then placed. However, the tumor recurred 16 months later, with extensive ventricular seeding and peritoneal metastasis through the shunt tube. The child died 22 months after onset. Histological study of surgical specimens of the primary tumor and autopsy specimens of the brain and peritoneal metastic tumors revealed poorly differentiated, small, round cells with numerous mitotic figures. In addition, autopsy specimens of the brain tumor contained areas of ependymal, oligodendroblastic, and spongioblastic differentiation. On immunohistochemical study, the tumor cells of each specimen were positive for antineuron specific enolase and anti-neurofilament antibodies, but negative for anti-glial fibrillary acidic protein antibodies. Electron microscopy revealed some zonulae adherens. These findings strongly suggest that the tumor originated from primitive multipotential cells capable of differentiating into ependymal, glial, and neuronal lines.

Original languageEnglish
Pages (from-to)1137-1143
Number of pages7
JournalNeurologia Medico-Chirurgica
Volume29
Issue number12
Publication statusPublished - 1989
Externally publishedYes

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Primitive Neuroectodermal Tumors
Ventriculoperitoneal Shunt
Neoplasm Metastasis
Neoplasms
Autopsy
Adherens Junctions
Lethargy
Intermediate Filaments
Phosphopyruvate Hydratase
Glial Fibrillary Acidic Protein
Hydrocephalus
Brain Neoplasms
Neuroglia
Drainage
Anti-Idiotypic Antibodies
Electron Microscopy
Antibodies
Brain

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Primitive neuroectodermal tumor with peritoneal metastasis through a ventriculoperitoneal shunt : Case report. / Yamamoto, Y.; Kunishio, K.; Suga, M.; Sunami, N.; Yamamoto, Yuji; Sonobe, H.

In: Neurologia Medico-Chirurgica, Vol. 29, No. 12, 1989, p. 1137-1143.

Research output: Contribution to journalArticle

Yamamoto, Y, Kunishio, K, Suga, M, Sunami, N, Yamamoto, Y & Sonobe, H 1989, 'Primitive neuroectodermal tumor with peritoneal metastasis through a ventriculoperitoneal shunt: Case report', Neurologia Medico-Chirurgica, vol. 29, no. 12, pp. 1137-1143.
Yamamoto, Y. ; Kunishio, K. ; Suga, M. ; Sunami, N. ; Yamamoto, Yuji ; Sonobe, H. / Primitive neuroectodermal tumor with peritoneal metastasis through a ventriculoperitoneal shunt : Case report. In: Neurologia Medico-Chirurgica. 1989 ; Vol. 29, No. 12. pp. 1137-1143.
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