Primary tracheal malignant lymphoma detected during a regular checkup in an asbestos dust-exposed smoker

Shoma Mizuno, Seisuke Ota, Takehiro Tanaka, Kohei Shiomi, Tadashi Matsumura, Nobuyasu Kishimoto

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Primary tracheal malignant lymphoma is a rare disease; only 30 cases have been reported to date. A 73-year-old Japanese man with a history of asbestos exposure was undergoing biannual chest computed tomography (CT) twice a year as a routine procedure for those previously exposed to asbestos. He had been smoking since the age of 32. In September 2010, chest CT during this regular checkup revealed a polypoid lesion in his trachea and pleural plaques, which were suspected to be caused by asbestos. Bronchoscopy performed in October revealed a polypoid lesion with granules and nodules in the trachea. A diagnosis of non-Hodgkin lymphoma (NHL) and extranodal marginal-zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) was confirmed by histological analysis of the biopsy specimens. To our knowledge, this is the first case of primary tracheal lymphoma associated with a history of asbestos exposure. Several reports have documented no correlation between asbestos and malignant lymphoma. In addition, the correlation between smoking and NHL is weak. Although we cannot exclude the possibility of a simple coincidence of asbestos, smoking, and tracheal lymphoma, this case suggests that asbestos and smoking might have multiplicative effects in the development or progression of tracheal lymphoma.

Original languageEnglish
Pages (from-to)177-181
Number of pages5
JournalActa Medica Okayama
Volume68
Issue number3
Publication statusPublished - 2014

Fingerprint

Asbestos
Dust
Lymphoma
Smoking
Marginal Zone B-Cell Lymphoma
Trachea
Non-Hodgkin's Lymphoma
Tomography
Thorax
Biopsy
Bronchoscopy
Rare Diseases
Cells
Tissue

Keywords

  • Asbestos
  • Bronchus-associated lymphoid tissue
  • Regular checkup
  • Smoking
  • Tracheal lymphoma

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Mizuno, S., Ota, S., Tanaka, T., Shiomi, K., Matsumura, T., & Kishimoto, N. (2014). Primary tracheal malignant lymphoma detected during a regular checkup in an asbestos dust-exposed smoker. Acta Medica Okayama, 68(3), 177-181.

Primary tracheal malignant lymphoma detected during a regular checkup in an asbestos dust-exposed smoker. / Mizuno, Shoma; Ota, Seisuke; Tanaka, Takehiro; Shiomi, Kohei; Matsumura, Tadashi; Kishimoto, Nobuyasu.

In: Acta Medica Okayama, Vol. 68, No. 3, 2014, p. 177-181.

Research output: Contribution to journalArticle

Mizuno, S, Ota, S, Tanaka, T, Shiomi, K, Matsumura, T & Kishimoto, N 2014, 'Primary tracheal malignant lymphoma detected during a regular checkup in an asbestos dust-exposed smoker', Acta Medica Okayama, vol. 68, no. 3, pp. 177-181.
Mizuno, Shoma ; Ota, Seisuke ; Tanaka, Takehiro ; Shiomi, Kohei ; Matsumura, Tadashi ; Kishimoto, Nobuyasu. / Primary tracheal malignant lymphoma detected during a regular checkup in an asbestos dust-exposed smoker. In: Acta Medica Okayama. 2014 ; Vol. 68, No. 3. pp. 177-181.
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