Primary tissue culture of spontaneously regressing flat warts. In vitro attack by mononuclear cells against wart-derived epidermal cells

H. Tagami, T. Oku, K. Iwatsuki

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Although tumors may be resolved due to host immune response, it is difficult to obtain direct evidence of this in man. Numerous flat warts, human papilloma virus type 3-induced papillomas, disappear systemically and simultaneously after showing inflammatory changes. Histologically, there is a dense cellular infiltration composed of lymphocytes and mononuclear phagocytes as identified by α-naphthyl acetate esterase staining in situ, the former being predominant in most cases. The primary tissue culture of such inflamed flat warts from 10 cases revealed a proliferation of wart-derived keratinocytes as is the case with ordinary flat warts. However, in 9 of the 10 cases, massive mononuclear cells, most of which were T-lymphocytes, migrated out of the explants and began to attack these keratinocytes, inducing degenerative changes. These findings indicate that cell-mediated tumor cell destruction rather than antiviral reaction induces systemic spontaneous regression of multiple papillomas in man.

Original languageEnglish
Pages (from-to)2437-2441
Number of pages5
JournalCancer
Volume55
Issue number10
Publication statusPublished - 1985
Externally publishedYes

Fingerprint

Warts
Papilloma
Keratinocytes
Papillomaviridae
Acetylesterase
Phagocytes
Antiviral Agents
Neoplasms
Lymphocytes
Staining and Labeling
T-Lymphocytes
In Vitro Techniques

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Primary tissue culture of spontaneously regressing flat warts. In vitro attack by mononuclear cells against wart-derived epidermal cells. / Tagami, H.; Oku, T.; Iwatsuki, K.

In: Cancer, Vol. 55, No. 10, 1985, p. 2437-2441.

Research output: Contribution to journalArticle

@article{a02d915c287a4352b592e89fd9484b08,
title = "Primary tissue culture of spontaneously regressing flat warts. In vitro attack by mononuclear cells against wart-derived epidermal cells",
abstract = "Although tumors may be resolved due to host immune response, it is difficult to obtain direct evidence of this in man. Numerous flat warts, human papilloma virus type 3-induced papillomas, disappear systemically and simultaneously after showing inflammatory changes. Histologically, there is a dense cellular infiltration composed of lymphocytes and mononuclear phagocytes as identified by α-naphthyl acetate esterase staining in situ, the former being predominant in most cases. The primary tissue culture of such inflamed flat warts from 10 cases revealed a proliferation of wart-derived keratinocytes as is the case with ordinary flat warts. However, in 9 of the 10 cases, massive mononuclear cells, most of which were T-lymphocytes, migrated out of the explants and began to attack these keratinocytes, inducing degenerative changes. These findings indicate that cell-mediated tumor cell destruction rather than antiviral reaction induces systemic spontaneous regression of multiple papillomas in man.",
author = "H. Tagami and T. Oku and K. Iwatsuki",
year = "1985",
language = "English",
volume = "55",
pages = "2437--2441",
journal = "Cancer",
issn = "0008-543X",
publisher = "John Wiley and Sons Inc.",
number = "10",

}

TY - JOUR

T1 - Primary tissue culture of spontaneously regressing flat warts. In vitro attack by mononuclear cells against wart-derived epidermal cells

AU - Tagami, H.

AU - Oku, T.

AU - Iwatsuki, K.

PY - 1985

Y1 - 1985

N2 - Although tumors may be resolved due to host immune response, it is difficult to obtain direct evidence of this in man. Numerous flat warts, human papilloma virus type 3-induced papillomas, disappear systemically and simultaneously after showing inflammatory changes. Histologically, there is a dense cellular infiltration composed of lymphocytes and mononuclear phagocytes as identified by α-naphthyl acetate esterase staining in situ, the former being predominant in most cases. The primary tissue culture of such inflamed flat warts from 10 cases revealed a proliferation of wart-derived keratinocytes as is the case with ordinary flat warts. However, in 9 of the 10 cases, massive mononuclear cells, most of which were T-lymphocytes, migrated out of the explants and began to attack these keratinocytes, inducing degenerative changes. These findings indicate that cell-mediated tumor cell destruction rather than antiviral reaction induces systemic spontaneous regression of multiple papillomas in man.

AB - Although tumors may be resolved due to host immune response, it is difficult to obtain direct evidence of this in man. Numerous flat warts, human papilloma virus type 3-induced papillomas, disappear systemically and simultaneously after showing inflammatory changes. Histologically, there is a dense cellular infiltration composed of lymphocytes and mononuclear phagocytes as identified by α-naphthyl acetate esterase staining in situ, the former being predominant in most cases. The primary tissue culture of such inflamed flat warts from 10 cases revealed a proliferation of wart-derived keratinocytes as is the case with ordinary flat warts. However, in 9 of the 10 cases, massive mononuclear cells, most of which were T-lymphocytes, migrated out of the explants and began to attack these keratinocytes, inducing degenerative changes. These findings indicate that cell-mediated tumor cell destruction rather than antiviral reaction induces systemic spontaneous regression of multiple papillomas in man.

UR - http://www.scopus.com/inward/record.url?scp=0021963709&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021963709&partnerID=8YFLogxK

M3 - Article

C2 - 3872707

AN - SCOPUS:0021963709

VL - 55

SP - 2437

EP - 2441

JO - Cancer

JF - Cancer

SN - 0008-543X

IS - 10

ER -