Primary small cell carcinoma of the breast

Takashi Hojo, Takayuki Kinoshita, Tadahiko Shien, Kotoe Terada, Shigemichi Hirose, You Isobe, Shunji Ikeuchi, Kiyoshi Kubochi, Sumio Matsumoto, Akashi Tanaka Sadako

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Primary small cell carcinoma of the breast is a very rare disease, and only a few case reports have described small cell carcinoma of the breast that responds to chemotherapy. Here, we report a case of primary small cell carcinoma of the breast that was treated with surgery and chemotherapy for postoperative local recurrence in the chest wall and metastasis to the liver. The metastatic lesions showed a partial response (PR) to carboplatin and irinotecan, but did not respond to subsequent Taxotere and doxifluridine (5-DFUR) treatment. We then treated the metastatic lesions with CBDCA and etoposide (VP-16), and were able to stop disease progression. Small cell carcinoma of the breast is as aggressive as its pulmonary counterpart. Therefore, the best therapy for primary small cell carcinoma of the breast may be surgery followed by adjuvant therapy similar to that recommended for small cell lung carcinoma.

Original languageEnglish
Pages (from-to)68-71
Number of pages4
JournalBreast Cancer
Volume16
Issue number1
DOIs
Publication statusPublished - Jan 2009
Externally publishedYes

Fingerprint

Small Cell Carcinoma
Breast
irinotecan
Carboplatin
docetaxel
Etoposide
Drug Therapy
Small Cell Lung Carcinoma
Thoracic Wall
Rare Diseases
Disease Progression
Therapeutics
Neoplasm Metastasis
Recurrence
Lung
Liver

Keywords

  • Breast
  • Chemotherapy
  • Small cell carcinoma

ASJC Scopus subject areas

  • Medicine(all)
  • Oncology
  • Pharmacology (medical)
  • Radiology Nuclear Medicine and imaging

Cite this

Hojo, T., Kinoshita, T., Shien, T., Terada, K., Hirose, S., Isobe, Y., ... Sadako, A. T. (2009). Primary small cell carcinoma of the breast. Breast Cancer, 16(1), 68-71. https://doi.org/10.1007/s12282-008-0057-9

Primary small cell carcinoma of the breast. / Hojo, Takashi; Kinoshita, Takayuki; Shien, Tadahiko; Terada, Kotoe; Hirose, Shigemichi; Isobe, You; Ikeuchi, Shunji; Kubochi, Kiyoshi; Matsumoto, Sumio; Sadako, Akashi Tanaka.

In: Breast Cancer, Vol. 16, No. 1, 01.2009, p. 68-71.

Research output: Contribution to journalArticle

Hojo, T, Kinoshita, T, Shien, T, Terada, K, Hirose, S, Isobe, Y, Ikeuchi, S, Kubochi, K, Matsumoto, S & Sadako, AT 2009, 'Primary small cell carcinoma of the breast', Breast Cancer, vol. 16, no. 1, pp. 68-71. https://doi.org/10.1007/s12282-008-0057-9
Hojo T, Kinoshita T, Shien T, Terada K, Hirose S, Isobe Y et al. Primary small cell carcinoma of the breast. Breast Cancer. 2009 Jan;16(1):68-71. https://doi.org/10.1007/s12282-008-0057-9
Hojo, Takashi ; Kinoshita, Takayuki ; Shien, Tadahiko ; Terada, Kotoe ; Hirose, Shigemichi ; Isobe, You ; Ikeuchi, Shunji ; Kubochi, Kiyoshi ; Matsumoto, Sumio ; Sadako, Akashi Tanaka. / Primary small cell carcinoma of the breast. In: Breast Cancer. 2009 ; Vol. 16, No. 1. pp. 68-71.
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