Primary small cell carcinoma of the breast

Takashi Hojo, Takayuki Kinoshita, Tadahiko Shien, Kotoe Terada, Shigemichi Hirose, You Isobe, Shunji Ikeuchi, Kiyoshi Kubochi, Sumio Matsumoto, Akashi Tanaka Sadako

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Primary small cell carcinoma of the breast is a very rare disease, and only a few case reports have described small cell carcinoma of the breast that responds to chemotherapy. Here, we report a case of primary small cell carcinoma of the breast that was treated with surgery and chemotherapy for postoperative local recurrence in the chest wall and metastasis to the liver. The metastatic lesions showed a partial response (PR) to carboplatin and irinotecan, but did not respond to subsequent Taxotere and doxifluridine (5-DFUR) treatment. We then treated the metastatic lesions with CBDCA and etoposide (VP-16), and were able to stop disease progression. Small cell carcinoma of the breast is as aggressive as its pulmonary counterpart. Therefore, the best therapy for primary small cell carcinoma of the breast may be surgery followed by adjuvant therapy similar to that recommended for small cell lung carcinoma.

Original languageEnglish
Pages (from-to)68-71
Number of pages4
JournalBreast Cancer
Volume16
Issue number1
DOIs
Publication statusPublished - Jan 1 2009
Externally publishedYes

Keywords

  • Breast
  • Chemotherapy
  • Small cell carcinoma

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Pharmacology (medical)

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  • Cite this

    Hojo, T., Kinoshita, T., Shien, T., Terada, K., Hirose, S., Isobe, Y., Ikeuchi, S., Kubochi, K., Matsumoto, S., & Sadako, A. T. (2009). Primary small cell carcinoma of the breast. Breast Cancer, 16(1), 68-71. https://doi.org/10.1007/s12282-008-0057-9