Primary Sclerosing Cholangitis in Japanese Patients: Association with Inflammatory Bowel Disease

Hiroyuki Okada, Motowo Mizuno, Kazuhide Yamamoto, Takao Tsuji

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Abstract

To characterize primary sclerosing cholangitis (PSC) in Japanese patients and its association with inflammatory bowel disease (IBD), 155 reported cases of PSC, including 6 cases of our own, were reviewed. The prevalence of IBD was less in Japanese PSC patients than in Western patients (23% versus 62-100%). Japanese PSC patients with IBD were younger (mean age, 33.1 versus 51.8 years) and were more often women (51% versus 36%) than those without IBD. Seventy-four percent of PSC patients with IBD had extensive colonic lesions, and 89% of those developed IBD simultaneously with or prior to PSC. There were 3 cases of neutrophilic cholangitis among the PSC patients with IBD but none in those without IBD. Based on these observations, we speculate that there may be subtypes of PSC which differ pathophysiologically.

Original languageEnglish
Pages (from-to)227-235
Number of pages9
JournalActa Medica Okayama
Volume50
Issue number5
Publication statusPublished - Oct 1996

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Keywords

  • Inflammatory bowel disease
  • Primary sclerosing cholangitis

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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