Primary osteosarcoma of the cerebrum with immunohistochemical and ultrastructural studies: report of a case

Nobuya Ohara, Kazuhiko Hayashi, Chie Shinohara, Masato Kamitani, Tomohisa Furuta, Tadashi Yoshino, Kiyoshi Takahashi, Kohji Taguchi, Tadaatsu Akagi

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

A 57-year-old woman with primary intracerebral osteosarcoma is reported. The tumor was identified by computed tomography as a mass with hemorrhage in the right parietal lobe. The surgical and pathological examinations confirmed an osteosarcoma of intracerebral origin. She suffered from repeated local recurrence of the tumor and died about 1 year after the onset. The pathological findings showed features of osteoblastic osteosarcoma with numerous osteoclastlike multinucleated giant cells. Immunohistochemically, tumor cells were positive for vimentin, and partially for actin. Multinucleated giant cells were reactive with vimentin and CD68 antibodies. Ultrastructurally, tumor cells were rich with rough endoplasmic reticulum. These findings are consistent with the histological features of skeletal or extraskeletal osteosarcoma. This is the third case of primary intracerebral osteosarcoma reported in the literature and the first one analyzed ultrastructurally.

Original languageEnglish
Pages (from-to)384-388
Number of pages5
JournalActa neuropathologica
Volume88
Issue number4
DOIs
Publication statusPublished - Oct 1994

Keywords

  • Brain neoplasms
  • Extraskeletal osteosarcoma
  • Multinucleated giant cells
  • Ultrastructure

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

Fingerprint Dive into the research topics of 'Primary osteosarcoma of the cerebrum with immunohistochemical and ultrastructural studies: report of a case'. Together they form a unique fingerprint.

Cite this