Primary non-Hodgkin malignant lymphoma of the breast: An immunohistochemical study of seven patients and literature review of 152 patients with breast lymphoma in Japan

Jong Jeon Ho Jong Jeon, T. Akagi, Y. Hoshida, K. Hayashi, Tadashi Yoshino, T. Tanaka, J. Ito, T. Kamei, K. Kawabata

Research output: Contribution to journalArticle

95 Citations (Scopus)

Abstract

Background. The breast is rarely a primary site for extranodal malignant lymphoma. Most reported primary non-Hodgkin malignant lymphomas of the breast (PBL) are of B-cell phenotype. Methods. Histologic and immunohistochemical analyses of seven patients with PBL and a statistical analysis of 152 patients with PBL reported in the Japanese literature were performed. Results. Malignant lymphoma could not be predicted preoperatively with clinical and radiologic findings; breast carcinoma, fibroadenoma, and phyllodes tumor were the preoperative diagnoses. All patients were women; they ranged in age from 31 to 80 years (mean, 57.6 years). The right breast was involved initially in five patients. In four, only the breast was involved (Stage I), whereas in three, the ipsilateral axillary lymph nodes (Stage II) were involved at diagnosis. According to the Working Formulation, all patients belonged to the intermediate grade and were classified as having diffuse large cell (five patients) or mixed (two patients) lymphoma. Immunophenotypic analysis revealed that all patients had B-cell lymphoma. No patients had lymphoepithelial lesions, which is the characteristic feature in categorizing a lymphoma as a mucosa-associated lymphoid tissue (MALT) lymphoma. A statistical analysis of the patient reported in the Japanese literature has divided PBL into two types: a bilateral type that affects younger women and a unilateral type that has a broad age distribution, but preponderantly occurs in older women. The age and stage at diagnosis were significant prognostic factors in predicting the survival time, but the location and size of the tumor at initial presentation, histopathologic type, terminal leukemic manifestation, and treatment modality were not. Conclusions. This study indicates that most PBL are diffuse large cell lymphoma of B-cell phenotype and that the age and stage at diagnosis are significant prognostic factors.

Original languageEnglish
Pages (from-to)2451-2459
Number of pages9
JournalCancer
Volume70
Issue number10
DOIs
Publication statusPublished - 1992

Fingerprint

Non-Hodgkin's Lymphoma
Lymphoma
Japan
Breast
B-Cell Lymphoma
Phyllodes Tumor
Phenotype
Fibroadenoma
Marginal Zone B-Cell Lymphoma
Lymphoma, Large B-Cell, Diffuse
Age Distribution
B-Lymphocytes
Lymph Nodes
Breast Neoplasms
Survival

Keywords

  • breast
  • immunohistochemistry
  • malignant lymphoma
  • statistical analysis

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Primary non-Hodgkin malignant lymphoma of the breast : An immunohistochemical study of seven patients and literature review of 152 patients with breast lymphoma in Japan. / Ho Jong Jeon, Jong Jeon; Akagi, T.; Hoshida, Y.; Hayashi, K.; Yoshino, Tadashi; Tanaka, T.; Ito, J.; Kamei, T.; Kawabata, K.

In: Cancer, Vol. 70, No. 10, 1992, p. 2451-2459.

Research output: Contribution to journalArticle

Ho Jong Jeon, Jong Jeon ; Akagi, T. ; Hoshida, Y. ; Hayashi, K. ; Yoshino, Tadashi ; Tanaka, T. ; Ito, J. ; Kamei, T. ; Kawabata, K. / Primary non-Hodgkin malignant lymphoma of the breast : An immunohistochemical study of seven patients and literature review of 152 patients with breast lymphoma in Japan. In: Cancer. 1992 ; Vol. 70, No. 10. pp. 2451-2459.
@article{7342927b7c0c4071afefd093e1bf083f,
title = "Primary non-Hodgkin malignant lymphoma of the breast: An immunohistochemical study of seven patients and literature review of 152 patients with breast lymphoma in Japan",
abstract = "Background. The breast is rarely a primary site for extranodal malignant lymphoma. Most reported primary non-Hodgkin malignant lymphomas of the breast (PBL) are of B-cell phenotype. Methods. Histologic and immunohistochemical analyses of seven patients with PBL and a statistical analysis of 152 patients with PBL reported in the Japanese literature were performed. Results. Malignant lymphoma could not be predicted preoperatively with clinical and radiologic findings; breast carcinoma, fibroadenoma, and phyllodes tumor were the preoperative diagnoses. All patients were women; they ranged in age from 31 to 80 years (mean, 57.6 years). The right breast was involved initially in five patients. In four, only the breast was involved (Stage I), whereas in three, the ipsilateral axillary lymph nodes (Stage II) were involved at diagnosis. According to the Working Formulation, all patients belonged to the intermediate grade and were classified as having diffuse large cell (five patients) or mixed (two patients) lymphoma. Immunophenotypic analysis revealed that all patients had B-cell lymphoma. No patients had lymphoepithelial lesions, which is the characteristic feature in categorizing a lymphoma as a mucosa-associated lymphoid tissue (MALT) lymphoma. A statistical analysis of the patient reported in the Japanese literature has divided PBL into two types: a bilateral type that affects younger women and a unilateral type that has a broad age distribution, but preponderantly occurs in older women. The age and stage at diagnosis were significant prognostic factors in predicting the survival time, but the location and size of the tumor at initial presentation, histopathologic type, terminal leukemic manifestation, and treatment modality were not. Conclusions. This study indicates that most PBL are diffuse large cell lymphoma of B-cell phenotype and that the age and stage at diagnosis are significant prognostic factors.",
keywords = "breast, immunohistochemistry, malignant lymphoma, statistical analysis",
author = "{Ho Jong Jeon}, {Jong Jeon} and T. Akagi and Y. Hoshida and K. Hayashi and Tadashi Yoshino and T. Tanaka and J. Ito and T. Kamei and K. Kawabata",
year = "1992",
doi = "10.1002/1097-0142(19921115)70:10<2451::AID-CNCR2820701011>3.0.CO;2-B",
language = "English",
volume = "70",
pages = "2451--2459",
journal = "Cancer",
issn = "0008-543X",
publisher = "John Wiley and Sons Inc.",
number = "10",

}

TY - JOUR

T1 - Primary non-Hodgkin malignant lymphoma of the breast

T2 - An immunohistochemical study of seven patients and literature review of 152 patients with breast lymphoma in Japan

AU - Ho Jong Jeon, Jong Jeon

AU - Akagi, T.

AU - Hoshida, Y.

AU - Hayashi, K.

AU - Yoshino, Tadashi

AU - Tanaka, T.

AU - Ito, J.

AU - Kamei, T.

AU - Kawabata, K.

PY - 1992

Y1 - 1992

N2 - Background. The breast is rarely a primary site for extranodal malignant lymphoma. Most reported primary non-Hodgkin malignant lymphomas of the breast (PBL) are of B-cell phenotype. Methods. Histologic and immunohistochemical analyses of seven patients with PBL and a statistical analysis of 152 patients with PBL reported in the Japanese literature were performed. Results. Malignant lymphoma could not be predicted preoperatively with clinical and radiologic findings; breast carcinoma, fibroadenoma, and phyllodes tumor were the preoperative diagnoses. All patients were women; they ranged in age from 31 to 80 years (mean, 57.6 years). The right breast was involved initially in five patients. In four, only the breast was involved (Stage I), whereas in three, the ipsilateral axillary lymph nodes (Stage II) were involved at diagnosis. According to the Working Formulation, all patients belonged to the intermediate grade and were classified as having diffuse large cell (five patients) or mixed (two patients) lymphoma. Immunophenotypic analysis revealed that all patients had B-cell lymphoma. No patients had lymphoepithelial lesions, which is the characteristic feature in categorizing a lymphoma as a mucosa-associated lymphoid tissue (MALT) lymphoma. A statistical analysis of the patient reported in the Japanese literature has divided PBL into two types: a bilateral type that affects younger women and a unilateral type that has a broad age distribution, but preponderantly occurs in older women. The age and stage at diagnosis were significant prognostic factors in predicting the survival time, but the location and size of the tumor at initial presentation, histopathologic type, terminal leukemic manifestation, and treatment modality were not. Conclusions. This study indicates that most PBL are diffuse large cell lymphoma of B-cell phenotype and that the age and stage at diagnosis are significant prognostic factors.

AB - Background. The breast is rarely a primary site for extranodal malignant lymphoma. Most reported primary non-Hodgkin malignant lymphomas of the breast (PBL) are of B-cell phenotype. Methods. Histologic and immunohistochemical analyses of seven patients with PBL and a statistical analysis of 152 patients with PBL reported in the Japanese literature were performed. Results. Malignant lymphoma could not be predicted preoperatively with clinical and radiologic findings; breast carcinoma, fibroadenoma, and phyllodes tumor were the preoperative diagnoses. All patients were women; they ranged in age from 31 to 80 years (mean, 57.6 years). The right breast was involved initially in five patients. In four, only the breast was involved (Stage I), whereas in three, the ipsilateral axillary lymph nodes (Stage II) were involved at diagnosis. According to the Working Formulation, all patients belonged to the intermediate grade and were classified as having diffuse large cell (five patients) or mixed (two patients) lymphoma. Immunophenotypic analysis revealed that all patients had B-cell lymphoma. No patients had lymphoepithelial lesions, which is the characteristic feature in categorizing a lymphoma as a mucosa-associated lymphoid tissue (MALT) lymphoma. A statistical analysis of the patient reported in the Japanese literature has divided PBL into two types: a bilateral type that affects younger women and a unilateral type that has a broad age distribution, but preponderantly occurs in older women. The age and stage at diagnosis were significant prognostic factors in predicting the survival time, but the location and size of the tumor at initial presentation, histopathologic type, terminal leukemic manifestation, and treatment modality were not. Conclusions. This study indicates that most PBL are diffuse large cell lymphoma of B-cell phenotype and that the age and stage at diagnosis are significant prognostic factors.

KW - breast

KW - immunohistochemistry

KW - malignant lymphoma

KW - statistical analysis

UR - http://www.scopus.com/inward/record.url?scp=0026472397&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026472397&partnerID=8YFLogxK

U2 - 10.1002/1097-0142(19921115)70:10<2451::AID-CNCR2820701011>3.0.CO;2-B

DO - 10.1002/1097-0142(19921115)70:10<2451::AID-CNCR2820701011>3.0.CO;2-B

M3 - Article

C2 - 1423175

AN - SCOPUS:0026472397

VL - 70

SP - 2451

EP - 2459

JO - Cancer

JF - Cancer

SN - 0008-543X

IS - 10

ER -