Primary mediastinal tumors in children--comparison with mediastinal tumors in adults

A. Akashi, K. Nakahara, K. Ohno, Y. Fujii, H. Maeda, S. Miyoshi, A. Matsumura, K. Nakagawa, M. Minami, H. Matsuda

Research output: Contribution to journalArticle

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Abstract

During the past 43 years, 628 patients with a primary mediastinal tumor underwent surgical operation in our institution. Of those patients, 106 patients (16.9%) were children of 15 yr of age or less and 522 patients (83.1%) were adults. 47 (44.3%) of the 106 children had neurogenic tumors, while 21 patients (19.8%) had a teratoma. 189 (36.2%) of the 522 adults had thymoma and 89 patients (17.1%) had teratoma. In the 106 children there were 71 benign tumor patients (66.9%) and 35 malignant tumor patients (33.1%). There were 277 (53.1%) benign and 245 (46.95) malignant tumors in the 522 adults. The adults had significantly more malignant tumors than the children (p <0.01). In our series of malignant mediastinal tumors in children, 14 patients (13.3%) had a lymphoma and 11 patients (10.5%) had a neuroblastoma. On the other hand, in the adults, 127 patients (24.3%) had a thymoma and 66 patients (12.6%) had a lymphoma. Regarding benign mediastinal tumors, in children, 30 patients (28.5%) had a ganglioneuroma and 19 patients (18.0%) had a teratoma. In the adults, 68 patients (13.0%) had a teratoma and 62 patients (11.9%) had a thymoma. In the clinical manifestation, 51 child patients (48.1%) and 191 adult patients (36.6%) were asymptomatic. As symptoms due to compression or direct invasion to adjacent structures, dyspnea was seen in 16 child patients (15.1%), and chest pain occurred in 59 adult patients (11.3%). Dyspnea was significantly more common in children than in in adults (p <0.01). Emergency operations were performed in children more than in adults.

Original languageEnglish
Pages (from-to)2180-2184
Number of pages5
JournalJournal of the Japanese Association for Thoracic Surgery
Volume41
Issue number11
Publication statusPublished - Nov 1993
Externally publishedYes

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Neoplasms
Teratoma
Thymoma
Dyspnea
Lymphoma
Ganglioneuroma
Chest Pain
Neuroblastoma
Emergencies

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Akashi, A., Nakahara, K., Ohno, K., Fujii, Y., Maeda, H., Miyoshi, S., ... Matsuda, H. (1993). Primary mediastinal tumors in children--comparison with mediastinal tumors in adults. Journal of the Japanese Association for Thoracic Surgery, 41(11), 2180-2184.

Primary mediastinal tumors in children--comparison with mediastinal tumors in adults. / Akashi, A.; Nakahara, K.; Ohno, K.; Fujii, Y.; Maeda, H.; Miyoshi, S.; Matsumura, A.; Nakagawa, K.; Minami, M.; Matsuda, H.

In: Journal of the Japanese Association for Thoracic Surgery, Vol. 41, No. 11, 11.1993, p. 2180-2184.

Research output: Contribution to journalArticle

Akashi, A, Nakahara, K, Ohno, K, Fujii, Y, Maeda, H, Miyoshi, S, Matsumura, A, Nakagawa, K, Minami, M & Matsuda, H 1993, 'Primary mediastinal tumors in children--comparison with mediastinal tumors in adults', Journal of the Japanese Association for Thoracic Surgery, vol. 41, no. 11, pp. 2180-2184.
Akashi A, Nakahara K, Ohno K, Fujii Y, Maeda H, Miyoshi S et al. Primary mediastinal tumors in children--comparison with mediastinal tumors in adults. Journal of the Japanese Association for Thoracic Surgery. 1993 Nov;41(11):2180-2184.
Akashi, A. ; Nakahara, K. ; Ohno, K. ; Fujii, Y. ; Maeda, H. ; Miyoshi, S. ; Matsumura, A. ; Nakagawa, K. ; Minami, M. ; Matsuda, H. / Primary mediastinal tumors in children--comparison with mediastinal tumors in adults. In: Journal of the Japanese Association for Thoracic Surgery. 1993 ; Vol. 41, No. 11. pp. 2180-2184.
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abstract = "During the past 43 years, 628 patients with a primary mediastinal tumor underwent surgical operation in our institution. Of those patients, 106 patients (16.9{\%}) were children of 15 yr of age or less and 522 patients (83.1{\%}) were adults. 47 (44.3{\%}) of the 106 children had neurogenic tumors, while 21 patients (19.8{\%}) had a teratoma. 189 (36.2{\%}) of the 522 adults had thymoma and 89 patients (17.1{\%}) had teratoma. In the 106 children there were 71 benign tumor patients (66.9{\%}) and 35 malignant tumor patients (33.1{\%}). There were 277 (53.1{\%}) benign and 245 (46.95) malignant tumors in the 522 adults. The adults had significantly more malignant tumors than the children (p <0.01). In our series of malignant mediastinal tumors in children, 14 patients (13.3{\%}) had a lymphoma and 11 patients (10.5{\%}) had a neuroblastoma. On the other hand, in the adults, 127 patients (24.3{\%}) had a thymoma and 66 patients (12.6{\%}) had a lymphoma. Regarding benign mediastinal tumors, in children, 30 patients (28.5{\%}) had a ganglioneuroma and 19 patients (18.0{\%}) had a teratoma. In the adults, 68 patients (13.0{\%}) had a teratoma and 62 patients (11.9{\%}) had a thymoma. In the clinical manifestation, 51 child patients (48.1{\%}) and 191 adult patients (36.6{\%}) were asymptomatic. As symptoms due to compression or direct invasion to adjacent structures, dyspnea was seen in 16 child patients (15.1{\%}), and chest pain occurred in 59 adult patients (11.3{\%}). Dyspnea was significantly more common in children than in in adults (p <0.01). Emergency operations were performed in children more than in adults.",
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AU - Miyoshi, S.

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AU - Minami, M.

AU - Matsuda, H.

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