[Primary mediastinal lymphoma; a clinicopathologic case series].

Seiichiro Sugimoto, Junichi Sou, Yuho Maki, Takeshi Kurosaki, Masaomi Yamane, Shinichi Toyooka, Takahiro Oto, Shinichiro Miyoshi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Treatment for primary mediastinal lymphoma generally involves chemotherapy and radiotherapy, and treatment regimens depend on histologic subtypes of lymphoma. The histologic subtype of lymphoma is mostly determined by computed tomography (CT)-guided core-needle biopsy or surgical procedures, including thoracotomy, thoracoscopy and mediastinoscopy. We describe the clinicopathologic features and diagnostic procedures of 8 cases of primary mediastinal lymphoma. The male-to-female ratio was 1:1, and median age at diagnosis was 27 years. The median size of the primary mediastinal tumor on CT was 8.5 cm. Five patients were diagnosed by CT-guided core-needle biopsy, 1 by open biopsy and 2 by surgery. Three patients were diagnosed with nodular sclerosis Hodgkin lymphoma, 3 with mediastinal diffuse large B-cell lymphoma, 1 with precursor T-lymphoblastic leukemia/lymphoma and 1 with thymic extranodal marginal zone B-cell lymphoma. According to their histological subtypes, 5 patients were treated with chemoradiotherapy, 2 patients with chemotherapy and 1 patient of thymic extranodal marginal zone B-cell lymphoma with surgery alone. All patients survived in the median follow-up of 34.5 months. Appropriate biopsy procedure should be performed in patients with suspected mediastinal lymphoma.

Original languageEnglish
Pages (from-to)527-531
Number of pages5
JournalKyobu geka. The Japanese journal of thoracic surgery
Volume65
Issue number7
Publication statusPublished - Jul 2012

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Lymphoma
Large-Core Needle Biopsy
Marginal Zone B-Cell Lymphoma
Tomography
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Mediastinoscopy
Biopsy
Drug Therapy
Thoracoscopy
Lymphoma, Large B-Cell, Diffuse
Chemoradiotherapy
Sclerosis
Thoracotomy
Hodgkin Disease
Radiotherapy
Therapeutics
Neoplasms

ASJC Scopus subject areas

  • Medicine(all)

Cite this

[Primary mediastinal lymphoma; a clinicopathologic case series]. / Sugimoto, Seiichiro; Sou, Junichi; Maki, Yuho; Kurosaki, Takeshi; Yamane, Masaomi; Toyooka, Shinichi; Oto, Takahiro; Miyoshi, Shinichiro.

In: Kyobu geka. The Japanese journal of thoracic surgery, Vol. 65, No. 7, 07.2012, p. 527-531.

Research output: Contribution to journalArticle

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