Primary Lung Cancer Associated with Diffuse Granulomatous Lesions in the Pulmonary Parenchyma

Yoshihiko Segawa; Nagio Takigawa; Masayuki Okahara; Yoshinobu Maeda; Ichiro Takata; Masahumi Fujii; Hiroshi Mogami; Koichi Mandai; Mikio Kataoka

doi:10.2169/internalmedicine.35.728

Primary Lung Cancer Associated with Diffuse Granulomatous Lesions in the Pulmonary Parenchyma

Yoshihiko Segawa, Nagio Takigawa, Masayuki Okahara, Yoshinobu Maeda, Ichiro Takata, Masahumi Fujii, Hiroshi Mogami, Koichi Mandai, Mikio Kataoka

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

A 60-year-old man was admitted to our hospital for productive cough. Chest roentgenography and CT scan disclosed a left hilar tumor invading the mediastinum, with mediastinal lymphadenopathy and diffuse micronodular shadows in both lung fields. A biopsied sample of the tumor revealed squamous cell carcinoma, while noncaseating epithelioid cell granulomas were observed in the samples obtained by transbronchial lung biopsy. The granulomas in the pulmonary parenchyma were determined to be sarcoid reactions secondary to lung cancer, since there was no evidence of sarcoidosis. Combination chemotherapy was effective for the tumor, and the granulomas disappeared after completion of the chemotherapy. These findings suggest the presence of a relationship between sarcoid reactions and lung cancer in this case.

Original language	English
Pages (from-to)	728-731
Number of pages	4
Journal	Internal Medicine
Volume	35
Issue number	9
DOIs	https://doi.org/10.2169/internalmedicine.35.728
Publication status	Published - Sept 1996

Keywords

Lung cancer
Noncaseating epithelioid cell granuloma
Sarcoid reaction
Sarcoidosis

ASJC Scopus subject areas

Internal Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2169/internalmedicine.35.728

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title = "Primary Lung Cancer Associated with Diffuse Granulomatous Lesions in the Pulmonary Parenchyma",

abstract = "A 60-year-old man was admitted to our hospital for productive cough. Chest roentgenography and CT scan disclosed a left hilar tumor invading the mediastinum, with mediastinal lymphadenopathy and diffuse micronodular shadows in both lung fields. A biopsied sample of the tumor revealed squamous cell carcinoma, while noncaseating epithelioid cell granulomas were observed in the samples obtained by transbronchial lung biopsy. The granulomas in the pulmonary parenchyma were determined to be sarcoid reactions secondary to lung cancer, since there was no evidence of sarcoidosis. Combination chemotherapy was effective for the tumor, and the granulomas disappeared after completion of the chemotherapy. These findings suggest the presence of a relationship between sarcoid reactions and lung cancer in this case.",

keywords = "Lung cancer, Noncaseating epithelioid cell granuloma, Sarcoid reaction, Sarcoidosis",

author = "Yoshihiko Segawa and Nagio Takigawa and Masayuki Okahara and Yoshinobu Maeda and Ichiro Takata and Masahumi Fujii and Hiroshi Mogami and Koichi Mandai and Mikio Kataoka",

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AU - Segawa, Yoshihiko

AU - Takigawa, Nagio

AU - Okahara, Masayuki

AU - Maeda, Yoshinobu

AU - Takata, Ichiro

AU - Fujii, Masahumi

AU - Mogami, Hiroshi

AU - Mandai, Koichi

AU - Kataoka, Mikio

PY - 1996/9

Y1 - 1996/9

N2 - A 60-year-old man was admitted to our hospital for productive cough. Chest roentgenography and CT scan disclosed a left hilar tumor invading the mediastinum, with mediastinal lymphadenopathy and diffuse micronodular shadows in both lung fields. A biopsied sample of the tumor revealed squamous cell carcinoma, while noncaseating epithelioid cell granulomas were observed in the samples obtained by transbronchial lung biopsy. The granulomas in the pulmonary parenchyma were determined to be sarcoid reactions secondary to lung cancer, since there was no evidence of sarcoidosis. Combination chemotherapy was effective for the tumor, and the granulomas disappeared after completion of the chemotherapy. These findings suggest the presence of a relationship between sarcoid reactions and lung cancer in this case.

AB - A 60-year-old man was admitted to our hospital for productive cough. Chest roentgenography and CT scan disclosed a left hilar tumor invading the mediastinum, with mediastinal lymphadenopathy and diffuse micronodular shadows in both lung fields. A biopsied sample of the tumor revealed squamous cell carcinoma, while noncaseating epithelioid cell granulomas were observed in the samples obtained by transbronchial lung biopsy. The granulomas in the pulmonary parenchyma were determined to be sarcoid reactions secondary to lung cancer, since there was no evidence of sarcoidosis. Combination chemotherapy was effective for the tumor, and the granulomas disappeared after completion of the chemotherapy. These findings suggest the presence of a relationship between sarcoid reactions and lung cancer in this case.

KW - Lung cancer

KW - Noncaseating epithelioid cell granuloma

KW - Sarcoid reaction

KW - Sarcoidosis

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Primary Lung Cancer Associated with Diffuse Granulomatous Lesions in the Pulmonary Parenchyma

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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