Primary Lung Cancer Associated with Diffuse Granulomatous Lesions in the Pulmonary Parenchyma

Yoshihiko Segawa, Nagio Takigawa, Masayuki Okahara, Yoshinobu Maeda, Ichiro Takata, Masahumi Fujii, Hiroshi Mogami, Koichi Mandai, Mikio Kataoka

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

A 60-year-old man was admitted to our hospital for productive cough. Chest roentgenography and CT scan disclosed a left hilar tumor invading the mediastinum, with mediastinal lymphadenopathy and diffuse micronodular shadows in both lung fields. A biopsied sample of the tumor revealed squamous cell carcinoma, while noncaseating epithelioid cell granulomas were observed in the samples obtained by transbronchial lung biopsy. The granulomas in the pulmonary parenchyma were determined to be sarcoid reactions secondary to lung cancer, since there was no evidence of sarcoidosis. Combination chemotherapy was effective for the tumor, and the granulomas disappeared after completion of the chemotherapy. These findings suggest the presence of a relationship between sarcoid reactions and lung cancer in this case.

Original languageEnglish
Pages (from-to)728-731
Number of pages4
JournalInternal Medicine
Volume35
Issue number9
Publication statusPublished - Sep 1996

Fingerprint

Granuloma
Lung Neoplasms
Lung
Epithelioid Cells
Neoplasms
Mediastinum
Sarcoidosis
Combination Drug Therapy
Cough
Radiography
Squamous Cell Carcinoma
Thorax
Biopsy
Drug Therapy

Keywords

  • Lung cancer
  • Noncaseating epithelioid cell granuloma
  • Sarcoid reaction
  • Sarcoidosis

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Segawa, Y., Takigawa, N., Okahara, M., Maeda, Y., Takata, I., Fujii, M., ... Kataoka, M. (1996). Primary Lung Cancer Associated with Diffuse Granulomatous Lesions in the Pulmonary Parenchyma. Internal Medicine, 35(9), 728-731.

Primary Lung Cancer Associated with Diffuse Granulomatous Lesions in the Pulmonary Parenchyma. / Segawa, Yoshihiko; Takigawa, Nagio; Okahara, Masayuki; Maeda, Yoshinobu; Takata, Ichiro; Fujii, Masahumi; Mogami, Hiroshi; Mandai, Koichi; Kataoka, Mikio.

In: Internal Medicine, Vol. 35, No. 9, 09.1996, p. 728-731.

Research output: Contribution to journalArticle

Segawa, Y, Takigawa, N, Okahara, M, Maeda, Y, Takata, I, Fujii, M, Mogami, H, Mandai, K & Kataoka, M 1996, 'Primary Lung Cancer Associated with Diffuse Granulomatous Lesions in the Pulmonary Parenchyma', Internal Medicine, vol. 35, no. 9, pp. 728-731.
Segawa Y, Takigawa N, Okahara M, Maeda Y, Takata I, Fujii M et al. Primary Lung Cancer Associated with Diffuse Granulomatous Lesions in the Pulmonary Parenchyma. Internal Medicine. 1996 Sep;35(9):728-731.
Segawa, Yoshihiko ; Takigawa, Nagio ; Okahara, Masayuki ; Maeda, Yoshinobu ; Takata, Ichiro ; Fujii, Masahumi ; Mogami, Hiroshi ; Mandai, Koichi ; Kataoka, Mikio. / Primary Lung Cancer Associated with Diffuse Granulomatous Lesions in the Pulmonary Parenchyma. In: Internal Medicine. 1996 ; Vol. 35, No. 9. pp. 728-731.
@article{f62b2795da3748d587cf17c44125083b,
title = "Primary Lung Cancer Associated with Diffuse Granulomatous Lesions in the Pulmonary Parenchyma",
abstract = "A 60-year-old man was admitted to our hospital for productive cough. Chest roentgenography and CT scan disclosed a left hilar tumor invading the mediastinum, with mediastinal lymphadenopathy and diffuse micronodular shadows in both lung fields. A biopsied sample of the tumor revealed squamous cell carcinoma, while noncaseating epithelioid cell granulomas were observed in the samples obtained by transbronchial lung biopsy. The granulomas in the pulmonary parenchyma were determined to be sarcoid reactions secondary to lung cancer, since there was no evidence of sarcoidosis. Combination chemotherapy was effective for the tumor, and the granulomas disappeared after completion of the chemotherapy. These findings suggest the presence of a relationship between sarcoid reactions and lung cancer in this case.",
keywords = "Lung cancer, Noncaseating epithelioid cell granuloma, Sarcoid reaction, Sarcoidosis",
author = "Yoshihiko Segawa and Nagio Takigawa and Masayuki Okahara and Yoshinobu Maeda and Ichiro Takata and Masahumi Fujii and Hiroshi Mogami and Koichi Mandai and Mikio Kataoka",
year = "1996",
month = "9",
language = "English",
volume = "35",
pages = "728--731",
journal = "Internal Medicine",
issn = "0918-2918",
publisher = "Japanese Society of Internal Medicine",
number = "9",

}

TY - JOUR

T1 - Primary Lung Cancer Associated with Diffuse Granulomatous Lesions in the Pulmonary Parenchyma

AU - Segawa, Yoshihiko

AU - Takigawa, Nagio

AU - Okahara, Masayuki

AU - Maeda, Yoshinobu

AU - Takata, Ichiro

AU - Fujii, Masahumi

AU - Mogami, Hiroshi

AU - Mandai, Koichi

AU - Kataoka, Mikio

PY - 1996/9

Y1 - 1996/9

N2 - A 60-year-old man was admitted to our hospital for productive cough. Chest roentgenography and CT scan disclosed a left hilar tumor invading the mediastinum, with mediastinal lymphadenopathy and diffuse micronodular shadows in both lung fields. A biopsied sample of the tumor revealed squamous cell carcinoma, while noncaseating epithelioid cell granulomas were observed in the samples obtained by transbronchial lung biopsy. The granulomas in the pulmonary parenchyma were determined to be sarcoid reactions secondary to lung cancer, since there was no evidence of sarcoidosis. Combination chemotherapy was effective for the tumor, and the granulomas disappeared after completion of the chemotherapy. These findings suggest the presence of a relationship between sarcoid reactions and lung cancer in this case.

AB - A 60-year-old man was admitted to our hospital for productive cough. Chest roentgenography and CT scan disclosed a left hilar tumor invading the mediastinum, with mediastinal lymphadenopathy and diffuse micronodular shadows in both lung fields. A biopsied sample of the tumor revealed squamous cell carcinoma, while noncaseating epithelioid cell granulomas were observed in the samples obtained by transbronchial lung biopsy. The granulomas in the pulmonary parenchyma were determined to be sarcoid reactions secondary to lung cancer, since there was no evidence of sarcoidosis. Combination chemotherapy was effective for the tumor, and the granulomas disappeared after completion of the chemotherapy. These findings suggest the presence of a relationship between sarcoid reactions and lung cancer in this case.

KW - Lung cancer

KW - Noncaseating epithelioid cell granuloma

KW - Sarcoid reaction

KW - Sarcoidosis

UR - http://www.scopus.com/inward/record.url?scp=0030225496&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030225496&partnerID=8YFLogxK

M3 - Article

VL - 35

SP - 728

EP - 731

JO - Internal Medicine

JF - Internal Medicine

SN - 0918-2918

IS - 9

ER -