Primary Lung Cancer Associated with Diffuse Granulomatous Lesions in the Pulmonary Parenchyma

Yoshihiko Segawa, Nagio Takigawa, Masayuki Okahara, Yoshinobu Maeda, Ichiro Takata, Masahumi Fujii, Hiroshi Mogami, Koichi Mandai, Mikio Kataoka

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


A 60-year-old man was admitted to our hospital for productive cough. Chest roentgenography and CT scan disclosed a left hilar tumor invading the mediastinum, with mediastinal lymphadenopathy and diffuse micronodular shadows in both lung fields. A biopsied sample of the tumor revealed squamous cell carcinoma, while noncaseating epithelioid cell granulomas were observed in the samples obtained by transbronchial lung biopsy. The granulomas in the pulmonary parenchyma were determined to be sarcoid reactions secondary to lung cancer, since there was no evidence of sarcoidosis. Combination chemotherapy was effective for the tumor, and the granulomas disappeared after completion of the chemotherapy. These findings suggest the presence of a relationship between sarcoid reactions and lung cancer in this case.

Original languageEnglish
Pages (from-to)728-731
Number of pages4
JournalInternal Medicine
Issue number9
Publication statusPublished - Sept 1996


  • Lung cancer
  • Noncaseating epithelioid cell granuloma
  • Sarcoid reaction
  • Sarcoidosis

ASJC Scopus subject areas

  • Internal Medicine


Dive into the research topics of 'Primary Lung Cancer Associated with Diffuse Granulomatous Lesions in the Pulmonary Parenchyma'. Together they form a unique fingerprint.

Cite this