Primary intraosseous squamous cell carcinomas

Five new clinicopathologic case studies

T. Yamada, T. Ueno, Norifumi Moritani, K. Mishima, A. Hirata, Tatsushi Matsumura

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Primary intraosseous squamous cell carcinomas (PIOSCCs) are rare malignant tumours which arise from odontogenic epithelial remnants. Herein we report five new PIOSCC cases, affecting three female and two male patients with a mean age of 64.4 years. One case involved the maxilla and four cases occurred in the mandible. Typical radiographic findings were ill-defined radiolucencies. Histopathologically, four cases were diagnosed as well-differentiated PIOSCCs arising de novo or from odontogenic cysts. The remaining case was a moderately differentiated de novo PIOSCC. In four cases, treatment consisted of surgical removal with perioperative radiotherapy or chemotherapy. To date, there have been no recurrences or distant metastases in three cases. The lesion was not locally controlled in one case and curative treatments were rejected in another case. PIOSCCs are thought to be important among radiolucent jaw lesions, and early diagnoses and surgical excision with sufficient margins of safety may allow for good prognoses.

Original languageEnglish
Pages (from-to)448-453
Number of pages6
JournalJournal of Cranio-Maxillofacial Surgery
Volume37
Issue number8
DOIs
Publication statusPublished - Dec 2009

Fingerprint

Squamous Cell Carcinoma
Odontogenic Cysts
Maxilla
Jaw
Mandible
Early Diagnosis
Radiotherapy
Neoplasm Metastasis
Safety
Recurrence
Drug Therapy
Therapeutics
Neoplasms

Keywords

  • mandible
  • maxilla
  • primary intraosseous squamous cell carcinoma
  • SCC

ASJC Scopus subject areas

  • Oral Surgery
  • Otorhinolaryngology
  • Surgery

Cite this

Primary intraosseous squamous cell carcinomas : Five new clinicopathologic case studies. / Yamada, T.; Ueno, T.; Moritani, Norifumi; Mishima, K.; Hirata, A.; Matsumura, Tatsushi.

In: Journal of Cranio-Maxillofacial Surgery, Vol. 37, No. 8, 12.2009, p. 448-453.

Research output: Contribution to journalArticle

@article{b422174348a34822a60886837bb3660b,
title = "Primary intraosseous squamous cell carcinomas: Five new clinicopathologic case studies",
abstract = "Primary intraosseous squamous cell carcinomas (PIOSCCs) are rare malignant tumours which arise from odontogenic epithelial remnants. Herein we report five new PIOSCC cases, affecting three female and two male patients with a mean age of 64.4 years. One case involved the maxilla and four cases occurred in the mandible. Typical radiographic findings were ill-defined radiolucencies. Histopathologically, four cases were diagnosed as well-differentiated PIOSCCs arising de novo or from odontogenic cysts. The remaining case was a moderately differentiated de novo PIOSCC. In four cases, treatment consisted of surgical removal with perioperative radiotherapy or chemotherapy. To date, there have been no recurrences or distant metastases in three cases. The lesion was not locally controlled in one case and curative treatments were rejected in another case. PIOSCCs are thought to be important among radiolucent jaw lesions, and early diagnoses and surgical excision with sufficient margins of safety may allow for good prognoses.",
keywords = "mandible, maxilla, primary intraosseous squamous cell carcinoma, SCC",
author = "T. Yamada and T. Ueno and Norifumi Moritani and K. Mishima and A. Hirata and Tatsushi Matsumura",
year = "2009",
month = "12",
doi = "10.1016/j.jcms.2009.05.006",
language = "English",
volume = "37",
pages = "448--453",
journal = "Journal of Cranio-Maxillo-Facial Surgery",
issn = "1010-5182",
publisher = "Churchill Livingstone",
number = "8",

}

TY - JOUR

T1 - Primary intraosseous squamous cell carcinomas

T2 - Five new clinicopathologic case studies

AU - Yamada, T.

AU - Ueno, T.

AU - Moritani, Norifumi

AU - Mishima, K.

AU - Hirata, A.

AU - Matsumura, Tatsushi

PY - 2009/12

Y1 - 2009/12

N2 - Primary intraosseous squamous cell carcinomas (PIOSCCs) are rare malignant tumours which arise from odontogenic epithelial remnants. Herein we report five new PIOSCC cases, affecting three female and two male patients with a mean age of 64.4 years. One case involved the maxilla and four cases occurred in the mandible. Typical radiographic findings were ill-defined radiolucencies. Histopathologically, four cases were diagnosed as well-differentiated PIOSCCs arising de novo or from odontogenic cysts. The remaining case was a moderately differentiated de novo PIOSCC. In four cases, treatment consisted of surgical removal with perioperative radiotherapy or chemotherapy. To date, there have been no recurrences or distant metastases in three cases. The lesion was not locally controlled in one case and curative treatments were rejected in another case. PIOSCCs are thought to be important among radiolucent jaw lesions, and early diagnoses and surgical excision with sufficient margins of safety may allow for good prognoses.

AB - Primary intraosseous squamous cell carcinomas (PIOSCCs) are rare malignant tumours which arise from odontogenic epithelial remnants. Herein we report five new PIOSCC cases, affecting three female and two male patients with a mean age of 64.4 years. One case involved the maxilla and four cases occurred in the mandible. Typical radiographic findings were ill-defined radiolucencies. Histopathologically, four cases were diagnosed as well-differentiated PIOSCCs arising de novo or from odontogenic cysts. The remaining case was a moderately differentiated de novo PIOSCC. In four cases, treatment consisted of surgical removal with perioperative radiotherapy or chemotherapy. To date, there have been no recurrences or distant metastases in three cases. The lesion was not locally controlled in one case and curative treatments were rejected in another case. PIOSCCs are thought to be important among radiolucent jaw lesions, and early diagnoses and surgical excision with sufficient margins of safety may allow for good prognoses.

KW - mandible

KW - maxilla

KW - primary intraosseous squamous cell carcinoma

KW - SCC

UR - http://www.scopus.com/inward/record.url?scp=70350570445&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70350570445&partnerID=8YFLogxK

U2 - 10.1016/j.jcms.2009.05.006

DO - 10.1016/j.jcms.2009.05.006

M3 - Article

VL - 37

SP - 448

EP - 453

JO - Journal of Cranio-Maxillo-Facial Surgery

JF - Journal of Cranio-Maxillo-Facial Surgery

SN - 1010-5182

IS - 8

ER -